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Mandla S, Davenport Huyer L, Radisic M. Review: Multimodal bioactive material approaches for wound healing. APL Bioeng. 2018;2(2):021503doi: 10.1063/1.5026773.
Mandla, S., Davenport Huyer, L., & Radisic, M. (2018). Review: Multimodal bioactive material approaches for wound healing. APL bioengineering, 2(2), 021503. https://doi.org/10.1063/1.5026773
Mandla, Serena, et al. "Review: Multimodal bioactive material approaches for wound healing." APL bioengineering vol. 2,2 (2018): 021503. doi: https://doi.org/10.1063/1.5026773
Mandla S, Davenport Huyer L, Radisic M. Review: Multimodal bioactive material approaches for wound healing. APL Bioeng. 2018 Jun 26;2(2):021503. doi: 10.1063/1.5026773. eCollection 2018 Jun. PMID: 31069297; PMCID: PMC6481710.
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APL Bioeng. 2018 Jun 26;2(2):021503. doi: 10.1063/1.5026773. eCollection 2018 Jun.

Review: Multimodal bioactive material approaches for wound healing.

APL bioengineering

Serena Mandla, Locke Davenport Huyer, Milica Radisic

Affiliations

  1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

PMID: 31069297 PMCID: PMC6481710 DOI: 10.1063/1.5026773

Abstract

Wound healing is a highly complex process of tissue repair that relies on the synergistic effect of a number of different cells, cytokines, enzymes, and growth factors. A deregulation in this process can lead to the formation of a non-healing chronic ulcer. Current treatment options, such as collagen wound dressings, are unable to meet the demand set by the wound environment. Therefore, a multifaceted bioactive dressing is needed to elicit a targeted affect. Wound healing strategies seek to develop a targeted effect through the delivery of a bioactive molecule to the wound by a hydrogel or a polymeric scaffold. This review examines current biomaterial and small molecule-based approaches that seek to develop a bioactive material for targeted wound therapy and accepted wound healing models for testing material efficacy.

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