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de Veras BO, Dos Santos YQ, Oliveira FGDS, et al. Algrizea Minor Sobral, Faria & Proença (Myrteae, Myrtaceae): chemical composition, antinociceptive, antimicrobial and antioxidant activity of essential oil. Nat Prod Res. 2019;1-5doi: 10.1080/14786419.2019.1602832.
de Veras, B. O., Dos Santos, Y. Q., Oliveira, F. G. D. S., Almeida, J. R. G. D. S., da Silva, A. G., Correia, M. T. D. S., Diniz, K. M., de Oliveira, J. R. S., Lima, V. L. M., Navarro, D. M. D. A. F., de Aguiar, J. C. R. O. F., de Oliveira, M. B. M., Lopes, A. C. S., & da Silva, M. V. (2019). Algrizea Minor Sobral, Faria & Proença (Myrteae, Myrtaceae): chemical composition, antinociceptive, antimicrobial and antioxidant activity of essential oil. Natural product research, 1-5. https://doi.org/10.1080/14786419.2019.1602832
de Veras, Bruno Oliveira, et al. "Algrizea Minor Sobral, Faria & Proença (Myrteae, Myrtaceae): chemical composition, antinociceptive, antimicrobial and antioxidant activity of essential oil." Natural product research vol. (2019): 1-5. doi: https://doi.org/10.1080/14786419.2019.1602832
de Veras BO, Dos Santos YQ, Oliveira FGDS, Almeida JRGDS, da Silva AG, Correia MTDS, Diniz KM, de Oliveira JRS, Lima VLM, Navarro DMDAF, de Aguiar JCROF, de Oliveira MBM, Lopes ACS, da Silva MV. Algrizea Minor Sobral, Faria & Proença (Myrteae, Myrtaceae): chemical composition, antinociceptive, antimicrobial and antioxidant activity of essential oil. Nat Prod Res. 2019 Apr 23;1-5. doi: 10.1080/14786419.2019.1602832. Epub 2019 Apr 23. PMID: 31014086.
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Nat Prod Res. 2019 Apr 23;1-5. doi: 10.1080/14786419.2019.1602832. Epub 2019 Apr 23.

Algrizea Minor Sobral, Faria & Proença (Myrteae, Myrtaceae): chemical composition, antinociceptive, antimicrobial and antioxidant activity of essential oil.

Natural product research

Bruno Oliveira de Veras, Yago Queiroz Dos Santos, Fernanda Granja da Silva Oliveira, Jackson Roberto Guedes da Silva Almeida, Alexandre Gomes da Silva, Maria Tereza Dos Santos Correia, Katharina Marques Diniz, João Ricardhis Saturnino de Oliveira, Vera Lúcia de Menezes Lima, Daniela Maria do Amaral Ferraz Navarro, Júlio César Ribeiro de Oliveira Farias de Aguiar, Maria Betânia Melo de Oliveira, Ana Catarina de Souza Lopes, Márcia Vanusa da Silva

Affiliations

  1. a Department of Medicine Tropical , Federal University of Pernambuco , Recife , Brazil.
  2. b Department of Biochemistry , Federal University of Rio Grande do Norte , Fortaleza , Brazil.
  3. c Post-graduation on Biotechnology , State University of Feira de Santana , Feira de Santana , Brazil.
  4. d Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley , Petrolina , Brazil.
  5. e Department of Biochemistry , Federal University of Pernambuco , Recife , Brazil.
  6. f Department of Chemistry , Federal University of Pernambuco , Recife , Brazil.

PMID: 31014086 DOI: 10.1080/14786419.2019.1602832

Abstract

This work aimed to investigate the chemical composition, antimicrobial, antinociceptive, acute toxicity and antioxidant activity of the essential oil of Algrizea minor (EOAm). The essential oil presented as the major constituents β-Pinene (56.99%), α-Pinene (16.57%), Germacrene D (4.67%), Bicyclogermacrene (4.66%), (E)-Caryophyllene (3.76%) and Limonene (1.71%). It was verified that the essential oil did not show acute toxicity in the maximum dose of 5,000 mg/kg. In the evaluation of the antinociceptive activity it was verified that the essential oil reduced in 65.84% the number of writhing in the mice, reducing the pain in 59.17%, and the mechanism of action in pain reduction was opioid, similar to morphine. The essential oil also presented significant antimicrobial against Gram positive and Gram-negative bacteria and fungi, and the antioxidant activity was relevant. Therefore, these results demonstrate the great potential for the future development of pharmaceutical products with the essential oil of Algrizea minor (EOAm).

Keywords: ; Myrtaceae; biological activity; chemical composition; essential oil

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