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Sur LM, Sur G, Samasca G, et al. Investigations of cellular immunity in juvenile idiopathic arthritis. Cent Eur J Immunol. 2019;44(1):92-96doi: 10.5114/ceji.2019.83615.
Sur, L. M., Sur, G., Samasca, G., & Lupan, I. (2019). Investigations of cellular immunity in juvenile idiopathic arthritis. Central-European journal of immunology, 44(1), 92-96. https://doi.org/10.5114/ceji.2019.83615
Sur, Lucia Maria, et al. "Investigations of cellular immunity in juvenile idiopathic arthritis." Central-European journal of immunology vol. 44,1 (2019): 92-96. doi: https://doi.org/10.5114/ceji.2019.83615
Sur LM, Sur G, Samasca G, Lupan I. Investigations of cellular immunity in juvenile idiopathic arthritis. Cent Eur J Immunol. 2019;44(1):92-96. doi: 10.5114/ceji.2019.83615. Epub 2019 Apr 15. PMID: 31114442; PMCID: PMC6526591.
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Cent Eur J Immunol. 2019;44(1):92-96. doi: 10.5114/ceji.2019.83615. Epub 2019 Apr 15.

Investigations of cellular immunity in juvenile idiopathic arthritis.

Central-European journal of immunology

Lucia Maria Sur, Genel Sur, Gabriel Samasca, Iulia Lupan

Affiliations

  1. Department of Paediatrics I, "Iuliu Ha?ieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  2. Department of Paediatrics II, "Iuliu Ha?ieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  3. Department of Immunology, "Iuliu Ha?ieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  4. Department of Molecular Biology, "Babes-Bolyai" University, Cluj-Napoca, Romania.

PMID: 31114442 PMCID: PMC6526591 DOI: 10.5114/ceji.2019.83615

Abstract

The following was emphasised in an informative, educational issued on the American College of Rheumatology website in April 2017: "About one child in every 1000 develops some type of chronic arthritis. These disorders can affect children at any age, although rarely in the first six months of life. It is estimated that around 300,000 children in the United States have been diagnosed with the condition". Therefore, knowledge of immunological investigations in patients with juvenile idiopathic arthritis is important for finding new treatment pathways. Our aim was to assess the immunological investigations and immune system implications in juvenile idiopathic arthritis. We will discuss: a) the specifically targeted proteins - the citrullinated peptide antibodies; b) non-specifically targeted proteins - heat-shock proteins (anti-HSP60, -65, and -70 antibodies), CLEC16A, inflammasomes, and phagocyte-derived S100; c) interleukins - IL-1, IL-6, IL-10, IL-17, and IL-18; d) innate immunity - macrophage activation syndrome, natural killer cells, complement activity, and immune complexes; and e) therapeutic targets - monoclonal antibodies, JAK inhibitors, and intravenous immune globulin.

Keywords: immunological targets; immunopathology; juvenile idiopathic arthritis

Conflict of interest statement

The authors declare no conflict of interest.

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