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Pitman SK, Huynh T, Bjarnason TA, et al. A case report and focused literature review of d-penicillamine and severe neutropenia: A serious toxicity from a seldom-used drug. Clin Case Rep. 2019;7(5):990-994doi: 10.1002/ccr3.2125.
Pitman, S. K., Huynh, T., Bjarnason, T. A., An, J., & Malkhasyan, K. A. (2019). A case report and focused literature review of d-penicillamine and severe neutropenia: A serious toxicity from a seldom-used drug. Clinical case reports, 7(5), 990-994. https://doi.org/10.1002/ccr3.2125
Pitman, Stuart K, et al. "A case report and focused literature review of d-penicillamine and severe neutropenia: A serious toxicity from a seldom-used drug." Clinical case reports vol. 7,5 (2019): 990-994. doi: https://doi.org/10.1002/ccr3.2125
Pitman SK, Huynh T, Bjarnason TA, An J, Malkhasyan KA. A case report and focused literature review of d-penicillamine and severe neutropenia: A serious toxicity from a seldom-used drug. Clin Case Rep. 2019 Apr 09;7(5):990-994. doi: 10.1002/ccr3.2125. eCollection 2019 May. PMID: 31110732; PMCID: PMC6509885.
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Clin Case Rep. 2019 Apr 09;7(5):990-994. doi: 10.1002/ccr3.2125. eCollection 2019 May.

A case report and focused literature review of d-penicillamine and severe neutropenia: A serious toxicity from a seldom-used drug.

Clinical case reports

Stuart K Pitman, Tony Huynh, Thorarinn A Bjarnason, Josiah An, Karen A Malkhasyan

Affiliations

  1. Department of Pharmaceutical Care University of Iowa Healthcare Iowa City Iowa.
  2. College of Pharmacy University of Iowa Iowa City Iowa.
  3. University of Iowa Healthcare Iowa City Iowa.
  4. Yale-New Haven Hospital New Haven Connecticut.

PMID: 31110732 PMCID: PMC6509885 DOI: 10.1002/ccr3.2125

Abstract

Prescribing d-penicillamine for Wilson's disease must be accompanied by vigilant monitoring, including a complete blood cell count with differential. For most, this should occur once or twice weekly during the first month of therapy and during periods of dose escalation, then every two weeks for six additional months, then monthly.

Keywords: Wilson's disease; neutropenia; penicillamine

Conflict of interest statement

None declared.

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