Display options
Cite
Altafi D, Sadeghi S, Hojatian H, et al. Mitochondrial Polymorphisms, in The D-Loop Area, Are Associated with Brain Tumors. Cell J. 2019;21(3):350-356doi: 10.22074/cellj.2019.5947.
Altafi, D., Sadeghi, S., Hojatian, H., Torabi Afra, M., Pakizeh Kar, S., Gorji, M., & Houshmand, M. (2019). Mitochondrial Polymorphisms, in The D-Loop Area, Are Associated with Brain Tumors. Cell journal, 21(3), 350-356. https://doi.org/10.22074/cellj.2019.5947
Altafi, Donya, et al. "Mitochondrial Polymorphisms, in The D-Loop Area, Are Associated with Brain Tumors." Cell journal vol. 21,3 (2019): 350-356. doi: https://doi.org/10.22074/cellj.2019.5947
Altafi D, Sadeghi S, Hojatian H, Torabi Afra M, Pakizeh Kar S, Gorji M, Houshmand M. Mitochondrial Polymorphisms, in The D-Loop Area, Are Associated with Brain Tumors. Cell J. 2019 Oct;21(3):350-356. doi: 10.22074/cellj.2019.5947. Epub 2019 Jun 15. PMID: 31210442; PMCID: PMC6582428.
Copy Download .nbib Format: NLM
Share it on

Cell J. 2019 Oct;21(3):350-356. doi: 10.22074/cellj.2019.5947. Epub 2019 Jun 15.

Mitochondrial Polymorphisms, in The D-Loop Area, Are Associated with Brain Tumors.

Cell journal

Donya Altafi, Soha Sadeghi, Hamed Hojatian, Maryam Torabi Afra, Safoura Pakizeh Kar, Mojtaba Gorji, Massoud Houshmand

Affiliations

  1. Molecular Biology Department, NourDanesh Institute of Higher Education, Esfahan, Iran. Electronic Address:[email protected].
  2. Molecular Biology Department, NourDanesh Institute of Higher Education, Esfahan, Iran.
  3. Department of Biology, International University of Guilan, Guilan, Iran.
  4. Department of Hematology and Oncology, Lorestan Medical University, Lorestan, Iran.
  5. Department of Medical Genetics, National Institutes for Genetic Engineering and Biotechnology, Tehran, Iran.
  6. Research Center, Knowledge University, Erbil, Kurdistan Region, Iraq.Electronic Address: [email protected].

PMID: 31210442 PMCID: PMC6582428 DOI: 10.22074/cellj.2019.5947

Abstract

OBJECTIVE: This study was carried out to evaluate the relationship between mtDNA D-loop variations and the pathogenesis of a brain tumor.

MATERIALS AND METHODS: In this experimental study, 25 specimens of brain tumor tissue with their adjacent tissues from patients and 454 blood samples from different ethnic groups of the Iranian population, as the control group, were analysed by the polymerase chain reaction (PCR)-sequencing method.

RESULTS: Thirty-six variations of the D-loop area were observed in brain tumor tissues as well as the adjacent normal tissues. A significant difference of A750G (P=0.046), T15936C (P=0.013), C15884G (P=0.013), C16069T (P=0.049), T16126C (P=0.006), C16186T (P=0.022), T16189C (P=0.041), C16193T (P=0.045), C16223T (P=0.001), T16224C (P=0.013), C16234T (P=0.013), G16274A (P=0.009), T16311C (P=0.038), C16327T (P=0.045), C16355T (P=0.003), T16362C (P=0.006), G16384A (P=0.042), G16392A (P=0.013), G16394A (P=0.013), and G16477A (P=0.013) variants was found between the patients and the controls.

CONCLUSION: The results indicated individuals with C16069T [odds ratio (OR): 2.048], T16126C (OR: 2.226), C16186T (OR: 3.586), G16274A (OR: 4.831), C16355T (OR: 7.322), and T16362C (OR: 6.682) variants with an OR more than one are probably associated with a brain tumor. However, given the multifactorial nature of cancer, more investigation needs to be done to confirm this association.

Copyright© by Royan Institute. All rights reserved.

Keywords: Brain Tumor; D-Loop; Mitochondrial DNA

Conflict of interest statement

There is no conflict of interest in this study.

References

  1. Am J Hum Genet. 2000 Oct;67(4):1029-32 - PubMed
  2. Cancer Res. 2002 Nov 15;62(22):6470-4 - PubMed
  3. Leukemia. 2003 Aug;17(8):1437-47 - PubMed
  4. Nat Genet. 1992 Dec;2(4):324-9 - PubMed
  5. Neurology. 2003 Oct 14;61(7):903-8 - PubMed
  6. Br J Cancer. 2004 Jun 14;90(12):2390-6 - PubMed
  7. Mol Cancer Res. 2005 Jan;3(1):14-20 - PubMed
  8. Br J Cancer. 2006 Jan 30;94(2):268-74 - PubMed
  9. Am J Hum Genet. 2006 Jul;79(1):54-61 - PubMed
  10. Oncogene. 2006 Aug 7;25(34):4647-62 - PubMed
  11. Gynecol Oncol. 2007 Jan;104(1):129-33 - PubMed
  12. Eur J Hum Genet. 2007 Oct;15(10):1079-89 - PubMed
  13. Annu Rev Cell Biol. 1991;7:453-78 - PubMed
  14. J Forensic Sci. 2008 Jan;53(1):142-6 - PubMed
  15. BMC Cancer. 2008 Oct 08;8:292 - PubMed
  16. Neurogastroenterol Motil. 2009 Sep;21(9):936-e72 - PubMed
  17. Exp Neurol. 2010 Apr;222(2):243-55 - PubMed
  18. J Assist Reprod Genet. 2010 Nov;27(11):641-8 - PubMed
  19. Mol Biol Evol. 2011 Feb;28(2):1099-110 - PubMed
  20. BMC Genet. 2011 Jan 31;12:21 - PubMed
  21. BMC Genet. 2011 Aug 30;12:77 - PubMed
  22. PLoS One. 2011;6(11):e27750 - PubMed
  23. Am J Phys Anthropol. 2012 May;148(1):123-38 - PubMed
  24. Nature. 2013 Jan 31;493(7434):632-7 - PubMed
  25. Biochim Biophys Acta. 2014 Feb;1842(2):208-19 - PubMed
  26. Cancer Cell Int. 2013 Dec 05;13(1):120 - PubMed
  27. Mitochondrial DNA. 2015 Aug;26(4):579-82 - PubMed
  28. Proc Natl Acad Sci U S A. 1989 Oct;86(20):7952-6 - PubMed
  29. Neuro Oncol. 2016 Jan;18 Suppl 1:i1-i50 - PubMed
  30. Neuro Oncol. 2016 Mar;18 Suppl 2:ii26-ii36 - PubMed
  31. Mol Vis. 2016 May 16;22:454-71 - PubMed
  32. Neuro Oncol. 2017 Nov 6;19(suppl_5):v1-v88 - PubMed
  33. J Biol Chem. 1974 Dec 25;249(24):7991-5 - PubMed
  34. Nature. 1981 Apr 9;290(5806):457-65 - PubMed
  35. Nucleic Acids Res. 1981 Oct 24;9(20):5411-21 - PubMed
  36. Cytogenet Cell Genet. 1995;71(1):99-103 - PubMed
  37. Biochim Biophys Acta. 1994 Apr 12;1226(1):49-55 - PubMed
  38. Sci Am. 1997 Aug;277(2):40-7 - PubMed
  39. J Biol Chem. 1997 Oct 10;272(41):25409-12 - PubMed
  40. Int J Legal Med. 1998;112(1):27-30 - PubMed

Publication Types