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Beauvarlet J, Mergny JL, Djavaheri-Mergny M. Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis. Mol Cell Oncol. 2019;6(4):1604047doi: 10.1080/23723556.2019.1604047.
Beauvarlet, J., Mergny, J. L., & Djavaheri-Mergny, M. (2019). Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis. Molecular & cellular oncology, 6(4), 1604047. https://doi.org/10.1080/23723556.2019.1604047
Beauvarlet, Jennifer, et al. "Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis." Molecular & cellular oncology vol. 6,4 (2019): 1604047. doi: https://doi.org/10.1080/23723556.2019.1604047
Beauvarlet J, Mergny JL, Djavaheri-Mergny M. Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis. Mol Cell Oncol. 2019 May 08;6(4):1604047. doi: 10.1080/23723556.2019.1604047. eCollection 2019. PMID: 31211231; PMCID: PMC6548482.
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Mol Cell Oncol. 2019 May 08;6(4):1604047. doi: 10.1080/23723556.2019.1604047. eCollection 2019.

Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis.

Molecular & cellular oncology

Jennifer Beauvarlet, Jean-Louis Mergny, Mojgan Djavaheri-Mergny

Affiliations

  1. INSERM U1218, Institut Bergonié, Université de Bordeaux, Bordeaux, France.
  2. Institut Curie, PSL Research University, CNRS-UMR 9187, INSERM U1196, Orsay, France.
  3. Université Paris Sud, Université Paris-Saclay, CNRS-UMR 9187, INSERM U1196, Orsay, France.
  4. Université de Bordeaux, INSERM U1212, CNRS UMR 5320, ARNA Laboratory, IECB, Pessac, France.
  5. Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.
  6. Equipe labellisée par la Ligue contre le cancer, Université Paris Descartes, Université Sorbonne Paris Cité, Université Paris Diderot, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France.
  7. Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.

PMID: 31211231 PMCID: PMC6548482 DOI: 10.1080/23723556.2019.1604047

Abstract

G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand

Keywords: Cancer therapy; DNA damage response; G-quadruplex; autophagy; senescence

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