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Metabolites. 2019 Jun 08;9(6). doi: 10.3390/metabo9060109.

Characterization of Bulk Phosphatidylcholine Compositions in Human Plasma Using Side-Chain Resolving Lipidomics.

Metabolites

Jan D Quell, Werner Römisch-Margl, Mark Haid, Jan Krumsiek, Thomas Skurk, Anna Halama, Nisha Stephan, Jerzy Adamski, Hans Hauner, Dennis Mook-Kanamori, Robert P Mohney, Hannelore Daniel, Karsten Suhre, Gabi Kastenmüller

Affiliations

  1. Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany. [email protected].
  2. Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising-Weihenstephan, Germany. [email protected].
  3. Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany. [email protected].
  4. Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany. [email protected].
  5. Institute for Computational Biomedicine, Englander Institute for Precision Medicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York City, NY 10021, USA. [email protected].
  6. Institute of Computational Bioinformatics, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany. [email protected].
  7. ZIEL Institute for Food and Health, Core Facility Human Studies Technical University of Munich, 85354 Freising-Weihenstephan, Germany. [email protected].
  8. Else Kroener-Frensenius-Center of Nutritional Medicine, Technical University of Munich, 85354 Freising-Weihenstephan, Germany. [email protected].
  9. Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, P.O. Box 24144, Doha, Qatar. [email protected].
  10. Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, P.O. Box 24144, Doha, Qatar. [email protected].
  11. Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany. [email protected].
  12. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore. [email protected].
  13. Else Kroener-Frensenius-Center of Nutritional Medicine, Technical University of Munich, 85354 Freising-Weihenstephan, Germany. [email protected].
  14. Institute for Nutritional Medicine, University Hospital Klinikum rechts der Isar, Technical University of Munich, 80992 Munich, Germany. [email protected].
  15. Department of Clinical Epidemiology, Leiden University Medical Center, 2333 Leiden, The Netherlands. [email protected].
  16. Public Health and Primary Care, Leiden University Medical Center, 2333 Leiden, The Netherlands. [email protected].
  17. Metabolon, Inc., Morrisville, NC 27560, USA. [email protected].
  18. Chair of Nutrition Physiology, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising-Weihenstephan, Germany. [email protected].
  19. Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, P.O. Box 24144, Doha, Qatar. [email protected].
  20. Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany. [email protected].
  21. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. [email protected].

PMID: 31181753 PMCID: PMC6631474 DOI: 10.3390/metabo9060109

Abstract

Kit-based assays, such as Absolute

Keywords: fatty acid composition; harmonization; imputation; isobaric phosphatidylcholines; lipid species; lipidomics; metabolomics; phospholipids; platform comparison

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