Display options
Cite
Shaked D, Leibel DK, Katzel LI, et al. Disparities in Diffuse Cortical White Matter Integrity Between Socioeconomic Groups. Front Hum Neurosci. 2019;13:198doi: 10.3389/fnhum.2019.00198.
Shaked, D., Leibel, D. K., Katzel, L. I., Davatzikos, C., Gullapalli, R. P., Seliger, S. L., Erus, G., Evans, M. K., Zonderman, A. B., & Waldstein, S. R. (2019). Disparities in Diffuse Cortical White Matter Integrity Between Socioeconomic Groups. Frontiers in human neuroscience, 13198. https://doi.org/10.3389/fnhum.2019.00198
Shaked, Danielle, et al. "Disparities in Diffuse Cortical White Matter Integrity Between Socioeconomic Groups." Frontiers in human neuroscience vol. 13 (2019): 198. doi: https://doi.org/10.3389/fnhum.2019.00198
Shaked D, Leibel DK, Katzel LI, Davatzikos C, Gullapalli RP, Seliger SL, Erus G, Evans MK, Zonderman AB, Waldstein SR. Disparities in Diffuse Cortical White Matter Integrity Between Socioeconomic Groups. Front Hum Neurosci. 2019 Jun 12;13:198. doi: 10.3389/fnhum.2019.00198. eCollection 2019. PMID: 31244633; PMCID: PMC6581723.
Copy Download .nbib Format: NLM
Share it on

Front Hum Neurosci. 2019 Jun 12;13:198. doi: 10.3389/fnhum.2019.00198. eCollection 2019.

Disparities in Diffuse Cortical White Matter Integrity Between Socioeconomic Groups.

Frontiers in human neuroscience

Danielle Shaked, Daniel K Leibel, Leslie I Katzel, Christos Davatzikos, Rao P Gullapalli, Stephen L Seliger, Guray Erus, Michele K Evans, Alan B Zonderman, Shari R Waldstein

Affiliations

  1. Department of Psychology, University of Maryland, Baltimore, MD, United States.
  2. Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, Baltimore, MD, United States.
  3. Division of Gerontology and Geriatric Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
  4. Geriatric Research Education and Clinical Center, Baltimore VA Medical Center, Baltimore, MD, United States.
  5. Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States.
  6. Department of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, MD, United States.
  7. Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.

PMID: 31244633 PMCID: PMC6581723 DOI: 10.3389/fnhum.2019.00198

Abstract

There is a growing literature demonstrating a link between lower socioeconomic status (SES) and poorer neuroanatomical health, such as smaller total and regional gray and white matter volumes, as well as greater white matter lesion volumes. Little is known, however, about the relation between SES and white matter integrity. Here we examined the relation between SES and white matter integrity of the brain's primary cortical regions, and evaluated potential moderating influences of age and self-identified race. Participants were 192 neurologically intact, community-dwelling African American and White adults (mean age = 52 years; 44% male, 60% White, low SES = 52%) from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) SCAN study. Participants underwent 3.0-T cranial magnetic resonance imaging. Diffusion tensor imaging was used to estimate regional fractional anisotropy (FA) to quantify the brain's white matter integrity and trace to capture diffusivity. Multiple regression analyses examined independent and interactive associations of SES, age, and race with FA of the frontal, temporal, parietal, and occipital lobes bilaterally. Sensitivity analyses assessed the influence of several biopsychosocial risk factors on these associations. Exploratory analyses examined these relations with trace and using additional SES indicators. Results indicated there were no significant interactions of SES, age, and race for any region. Individuals with low SES had lower FA in all regions, and higher trace in the right and left frontal, right and left temporal, and left occipital lobes. Findings remained largely unchanged after inclusion of sensitivity variables. Older age was associated with lower FA and greater trace for all regions, except for the right temporal lobe with FA. No main effects were found for race in FA, and Whites had higher trace values in the parietal lobes. Novel findings of this study indicate that relative to the high SES group, low SES was associated with poorer white matter integrity and greater diffusivity. These results may, in part, reflect exposures to various biopsychosocial risk factors experienced by those of lower SES across the lifespan, and may help explain the preponderance of cognitive and functional disparities between socioeconomic groups.

Keywords: age; diffusion tensor imaging; health disparities; neuroanatomical health; race; socioeconomic status; white matter integrity

References

  1. Ann N Y Acad Sci. 1999;896:131-44 - PubMed
  2. Curr Psychiatry Rep. 2000 Feb;2(1):40-5 - PubMed
  3. Neurology. 2001 Jan 9;56(1):49-56 - PubMed
  4. Neurology. 2001 Aug 28;57(4):632-8 - PubMed
  5. Annu Rev Public Health. 2002;23:303-31 - PubMed
  6. Am J Epidemiol. 2003 Jan 15;157(2):98-112 - PubMed
  7. Ann Epidemiol. 2003 Jul;13(6):472-8 - PubMed
  8. Radiology. 2004 Jan;230(1):77-87 - PubMed
  9. Cereb Cortex. 2004 Apr;14(4):410-23 - PubMed
  10. Soc Sci Med. 2005 Jan;60(1):191-204 - PubMed
  11. BMC Public Health. 2005 Jan 20;5:7 - PubMed
  12. Neurobiol Aging. 2005 Aug-Sep;26(8):1215-27 - PubMed
  13. Ann Epidemiol. 2005 Sep;15(8):572-8 - PubMed
  14. Arch Intern Med. 2005 Oct 10;165(18):2098-104 - PubMed
  15. JAMA. 2005 Dec 14;294(22):2879-88 - PubMed
  16. Neurosci Biobehav Rev. 2006;30(6):749-61 - PubMed
  17. Neurosci Biobehav Rev. 2006;30(6):730-48 - PubMed
  18. Int Psychogeriatr. 2007 Aug;19(4):757-66 - PubMed
  19. Epidemiol Rev. 2007;29:6-28 - PubMed
  20. Dev Sci. 2007 Jul;10(4):464-80 - PubMed
  21. J Neurol Neurosurg Psychiatry. 2008 Jun;79(6):619-24 - PubMed
  22. J Cogn Neurosci. 2009 Feb;21(2):289-302 - PubMed
  23. Cortex. 2008 Sep;44(8):936-52 - PubMed
  24. Neuropsychol Rev. 2008 Sep;18(3):223-54 - PubMed
  25. Med Image Comput Comput Assist Interv. 2008;11(Pt 1):620-7 - PubMed
  26. J Psychiatry Neurosci. 2008 Nov;33(6):525-30 - PubMed
  27. Trends Cogn Sci. 2009 Feb;13(2):65-73 - PubMed
  28. J Alzheimers Dis. 2009;17(3):571-83 - PubMed
  29. J Gen Intern Med. 2009 Oct;24(10):1144-8 - PubMed
  30. Neuroimage. 2010 Feb 1;49(3):2083-93 - PubMed
  31. Med Image Anal. 2010 Apr;14(2):205-18 - PubMed
  32. J Alzheimers Dis. 2010;20(2):477-90 - PubMed
  33. Ann N Y Acad Sci. 2010 Feb;1186:69-101 - PubMed
  34. Ann N Y Acad Sci. 2010 Feb;1186:190-222 - PubMed
  35. Hum Brain Mapp. 2011 Feb;32(2):282-9 - PubMed
  36. Neurology. 2010 Mar 30;74(13):1022-9 - PubMed
  37. Neurobiol Aging. 2012 Jan;33(1):61-74 - PubMed
  38. IEEE Trans Med Imaging. 2010 Jun;29(6):1310-20 - PubMed
  39. Neuropsychol Rev. 2010 Jun;20(2):209-25 - PubMed
  40. Nat Rev Neurosci. 2010 Sep;11(9):651-9 - PubMed
  41. Ethn Dis. 2010 Summer;20(3):267-75 - PubMed
  42. Neuroimage. 2011 Feb 1;54(3):2308-17 - PubMed
  43. Hum Brain Mapp. 2011 Dec;32(12):2161-71 - PubMed
  44. Obesity (Silver Spring). 2011 Mar;19(3):500-4 - PubMed
  45. Brain. 2011 Jul;134(Pt 7):2116-24 - PubMed
  46. JAMA. 2011 Sep 21;306(11):1241-9 - PubMed
  47. Hum Brain Mapp. 2013 Nov;34(11):2972-85 - PubMed
  48. Cereb Cortex. 2013 Sep;23(9):2058-71 - PubMed
  49. PLoS One. 2012;7(8):e42486 - PubMed
  50. Neurology. 2012 Oct 23;79(17):1802-8 - PubMed
  51. Age (Dordr). 2013 Dec;35(6):2045-56 - PubMed
  52. Dev Sci. 2013 Sep;16(5):653-64 - PubMed
  53. Acad Radiol. 2013 Dec;20(12):1566-76 - PubMed
  54. Neuropsychopharmacology. 2014 May;39(6):1332-9 - PubMed
  55. PLoS One. 2014 Feb 18;9(2):e88969 - PubMed
  56. Diabetes. 2014 Nov;63(11):3596-605 - PubMed
  57. Front Neurosci. 2014 Sep 04;8:276 - PubMed
  58. Schizophr Res. 2015 Jan;161(1):42-9 - PubMed
  59. Neurology. 2015 Mar 17;84(11):1128-35 - PubMed
  60. Neuroimage. 2016 Jan 15;125:1063-1078 - PubMed
  61. Circulation. 2016 Jan 26;133(4):e38-360 - PubMed
  62. Alzheimers Dement. 2016 Mar;12(3):216-24 - PubMed
  63. BMC Public Health. 2016 Mar 14;16:258 - PubMed
  64. Brain Behav. 2016 Aug 02;6(10):e00531 - PubMed
  65. Psychosom Med. 2017 Apr;79(3):327-335 - PubMed
  66. Eur Arch Psychiatry Clin Neurosci. 2018 Mar;268(2):145-156 - PubMed
  67. Int J Environ Res Public Health. 2017 Aug 30;14(9): - PubMed
  68. Neuron. 2017 Sep 27;96(1):56-71 - PubMed
  69. Stroke. 2017 Dec;48(12):3196-3202 - PubMed
  70. Front Hum Neurosci. 2017 Nov 13;11:547 - PubMed
  71. J Community Health Nurs. 2018 Jan-Mar;35(1):28-37 - PubMed
  72. Aust N Z J Public Health. 2018 Apr;42(2):186-194 - PubMed
  73. Front Neuroendocrinol. 2018 Apr;49:146-169 - PubMed
  74. Neuropsychology. 2018 Nov;32(8):985-995 - PubMed
  75. Alzheimers Dement. 2018 Sep 14;: - PubMed
  76. Front Hum Neurosci. 2019 Jan 18;12:543 - PubMed
  77. PLoS One. 2019 May 9;14(5):e0216338 - PubMed
  78. Am Psychol. 1994 Jan;49(1):15-24 - PubMed
  79. Circulation. 1993 Oct;88(4 Pt 1):1973-98 - PubMed
  80. Gerontologist. 1996 Apr;36(2):230-8 - PubMed
  81. Stroke. 1997 Jan;28(1):15-8 - PubMed
  82. J Neuropsychiatry Clin Neurosci. 1996 Fall;8(4):399-403 - PubMed
  83. Neuroepidemiology. 1997;16(3):149-62 - PubMed

Publication Types

Grant support