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Uludag H, Ubeda A, Ansari A. At the Intersection of Biomaterials and Gene Therapy: Progress in Non-viral Delivery of Nucleic Acids. Front Bioeng Biotechnol. 2019;7:131doi: 10.3389/fbioe.2019.00131.
Uludag, H., Ubeda, A., & Ansari, A. (2019). At the Intersection of Biomaterials and Gene Therapy: Progress in Non-viral Delivery of Nucleic Acids. Frontiers in bioengineering and biotechnology, 7131. https://doi.org/10.3389/fbioe.2019.00131
Uludag, Hasan, et al. "At the Intersection of Biomaterials and Gene Therapy: Progress in Non-viral Delivery of Nucleic Acids." Frontiers in bioengineering and biotechnology vol. 7 (2019): 131. doi: https://doi.org/10.3389/fbioe.2019.00131
Uludag H, Ubeda A, Ansari A. At the Intersection of Biomaterials and Gene Therapy: Progress in Non-viral Delivery of Nucleic Acids. Front Bioeng Biotechnol. 2019 Jun 04;7:131. doi: 10.3389/fbioe.2019.00131. eCollection 2019. PMID: 31214586; PMCID: PMC6558074.
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Front Bioeng Biotechnol. 2019 Jun 04;7:131. doi: 10.3389/fbioe.2019.00131. eCollection 2019.

At the Intersection of Biomaterials and Gene Therapy: Progress in Non-viral Delivery of Nucleic Acids.

Frontiers in bioengineering and biotechnology

Hasan Uludag, Anyeld Ubeda, Aysha Ansari

Affiliations

  1. Department of Chemical and Materinals Engineering, University of Alberta, Edmonton, AB, Canada.
  2. Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada.
  3. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.

PMID: 31214586 PMCID: PMC6558074 DOI: 10.3389/fbioe.2019.00131

Abstract

Biomaterials play a critical role in technologies intended to deliver therapeutic agents in clinical settings. Recent explosion of our understanding of how cells utilize nucleic acids has garnered excitement to develop a range of older (e.g., antisense oligonucleotides, plasmid DNA and transposons) and emerging (e.g., short interfering RNA, messenger RNA and non-coding RNAs) nucleic acid agents for therapy of a wide range of diseases. This review will summarize biomaterials-centered advances to undertake effective utilization of nucleic acids for therapeutic purposes. We first review various types of nucleic acids and their unique abilities to deliver a range of clinical outcomes. Using recent advances in T-cell based therapy as a case in point, we summarize various possibilities for utilizing biomaterials to make an impact in this exciting therapeutic intervention technology, with the belief that this modality will serve as a therapeutic paradigm for other types of cellular therapies in the near future. We subsequently focus on contributions of biomaterials in emerging nucleic acid technologies, specifically focusing on the design of intelligent nanoparticles, deployment of mRNA as an alternative to plasmid DNA, long-acting (integrating) expression systems, and

Keywords: T-cell therapy; biomaterials; gene medicine; mRNA; nanoparticle; nucleic acid delivery; pDNA delivery; siRNA

References

  1. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3606-10 - PubMed
  2. Clin Mater. 1992;9(3-4):179-87 - PubMed
  3. Mol Med Today. 1999 Apr;5(4):178-86 - PubMed
  4. Chem Biol. 2000 May;7(5):345-54 - PubMed
  5. Nat Genet. 2000 May;25(1):35-41 - PubMed
  6. Nat Med. 2000 Dec;6(12):1406-10 - PubMed
  7. Pharmacol Rev. 2000 Dec;52(4):493-511 - PubMed
  8. Curr Opin Mol Ther. 2001 Jun;3(3):229-34 - PubMed
  9. Nat Med. 2002 Jan;8(1):47-53 - PubMed
  10. J Virol. 2002 Jul;76(13):6545-57 - PubMed
  11. Mol Ther. 2002 Jul;6(1):30-4 - PubMed
  12. Nucleic Acids Res. 2002 Sep 15;30(18):4001-8 - PubMed
  13. Nat Immunol. 2002 Nov;3(11):999-1005 - PubMed
  14. Nat Rev Cancer. 2003 Jan;3(1):35-45 - PubMed
  15. Nucleic Acids Res. 2003 Apr 1;31(7):1935-43 - PubMed
  16. RNA. 2003 Oct;9(10):1254-63 - PubMed
  17. J Exp Med. 1955 Aug 1;102(2):157-77 - PubMed
  18. Science. 1992 Jul 10;257(5067):238-41 - PubMed
  19. Biomaterials. 2004 Aug;25(19):4709-18 - PubMed
  20. Mol Ther. 2004 Aug;10(2):365-72 - PubMed
  21. Gene Ther. 2004 Sep;11(18):1363-9 - PubMed
  22. J Immunother. 2004 Sep-Oct;27(5):405-18 - PubMed
  23. Gene Ther. 2005 Mar;12(5):418-26 - PubMed
  24. Annu Rev Immunol. 1992;10:835-73 - PubMed
  25. Gene Ther. 2006 Jan;13(1):95-100 - PubMed
  26. Nucleic Acids Res. 2006 Jul 19;34(12):3577-84 - PubMed
  27. Mol Cancer Ther. 2006 Sep;5(9):2428-34 - PubMed
  28. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15008-13 - PubMed
  29. J Cell Mol Med. 2007 May-Jun;11(3):521-30 - PubMed
  30. Chem Rev. 2007 Sep;107(9):3715-43 - PubMed
  31. Mol Ther. 2008 Feb;16(2):359-69 - PubMed
  32. Nat Methods. 2008 Feb;5(2):135-46 - PubMed
  33. BMC Biotechnol. 2008 Feb 29;8:23 - PubMed
  34. Mol Ther. 2008 Apr;16(4):765-72 - PubMed
  35. Nucleic Acids Res. 2008 May;36(9):e49 - PubMed
  36. J Clin Invest. 2008 Sep;118(9):3132-42 - PubMed
  37. J Immunol. 2008 Sep 1;181(5):2990-8 - PubMed
  38. J Immunother. 2009 Feb-Mar;32(2):169-80 - PubMed
  39. Nat Methods. 2009 Jun;6(6):415-22 - PubMed
  40. Biomaterials. 2009 Oct;30(28):5143-55 - PubMed
  41. Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2726-30 - PubMed
  42. Discov Med. 2010 Apr;9(47):277-88 - PubMed
  43. Nat Rev Genet. 2010 Sep;11(9):636-46 - PubMed
  44. Curr Genomics. 2010 Apr;11(2):115-28 - PubMed
  45. J Transl Med. 2010 Oct 26;8:104 - PubMed
  46. Nucleic Acids Res. 2011 Apr;39(7):2981-94 - PubMed
  47. Nat Biotechnol. 2011 Feb;29(2):154-7 - PubMed
  48. Nat Mater. 2011 Mar;10(3):243-51 - PubMed
  49. Lancet. 2011 Aug 13;378(9791):595-605 - PubMed
  50. J Biotechnol. 2011 Oct 10;155(4):377-86 - PubMed
  51. Nucleic Acids Res. 2011 Dec;39(22):e155 - PubMed
  52. N Engl J Med. 2011 Nov 3;365(18):1673-83 - PubMed
  53. J Am Chem Soc. 2012 Jan 25;134(3):1376-91 - PubMed
  54. Cell. 1990 Nov 2;63(3):601-8 - PubMed
  55. J Biotechnol. 2012 Mar 31;158(1-2):44-9 - PubMed
  56. Cell Reprogram. 2012 Apr;14(2):130-7 - PubMed
  57. Sci Transl Med. 2012 May 2;4(132):132ra53 - PubMed
  58. Nat Nanotechnol. 2012 Jun 03;7(6):389-93 - PubMed
  59. Nano Lett. 2012 Jul 11;12(7):3867-71 - PubMed
  60. Angew Chem Int Ed Engl. 2012 Oct 22;51(43):10751-5 - PubMed
  61. Eur J Pharm Sci. 2013 Jan 23;48(1-2):259-71 - PubMed
  62. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2082-7 - PubMed
  63. Mol Pharm. 2013 Mar 4;10(3):1070-9 - PubMed
  64. Acta Biomater. 2013 Jul;9(7):7429-38 - PubMed
  65. Trends Biotechnol. 2013 Jul;31(7):397-405 - PubMed
  66. J Control Release. 2013 Dec 10;172(2):426-35 - PubMed
  67. Leuk Lymphoma. 2014 May;55(5):999-1006 - PubMed
  68. Int J Nanomedicine. 2013;8:2985-95 - PubMed
  69. Sci Transl Med. 2013 Oct 30;5(209):209ra152 - PubMed
  70. J Vis Exp. 2013 Nov 07;(81):e50980 - PubMed
  71. ACS Nano. 2014 Mar 25;8(3):2252-60 - PubMed
  72. Biomacromolecules. 2014 Jul 14;15(7):2656-62 - PubMed
  73. Mol Ther Nucleic Acids. 2014 May 27;3:e165 - PubMed
  74. Virol J. 2014 Jun 13;11:111 - PubMed
  75. Curr Gene Ther. 2014;14(4):309-29 - PubMed
  76. Nat Nanotechnol. 2014 Aug;9(8):639-47 - PubMed
  77. Mol Cell. 2014 Oct 2;56(1):55-66 - PubMed
  78. Leuk Res. 2014 Nov;38(11):1299-308 - PubMed
  79. Science. 2014 Nov 28;346(6213):1258096 - PubMed
  80. Nat Biotechnol. 2015 Jan;33(1):64-72 - PubMed
  81. Nat Biotechnol. 2015 Jan;33(1):97-101 - PubMed
  82. Biomaterials. 2015 May;50:67-74 - PubMed
  83. J Immunother. 2015 Apr;38(3):127-35 - PubMed
  84. Science. 2015 Apr 3;348(6230):74-80 - PubMed
  85. Mol Biotechnol. 2015 Aug;57(8):767-80 - PubMed
  86. Hum Gene Ther Methods. 2015 Aug;26(4):134-46 - PubMed
  87. Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12029-33 - PubMed
  88. J Control Release. 2015 Nov 28;218:22-8 - PubMed
  89. Ann Neurol. 2016 Feb;79(2):257-71 - PubMed
  90. J Control Release. 2016 Feb 28;224:8-21 - PubMed
  91. Biomaterials. 2016 May;87:131-146 - PubMed
  92. Br J Clin Pharmacol. 2016 Sep;82(3):659-72 - PubMed
  93. Blood. 2016 Jun 30;127(26):3312-20 - PubMed
  94. Mol Ther. 2016 Sep;24(9):1513-27 - PubMed
  95. Mol Ther Nucleic Acids. 2016 Jul 19;5(7):e337 - PubMed
  96. J Clin Invest. 2016 Sep 1;126(9):3363-76 - PubMed
  97. Leukemia. 2017 Jan;31(1):186-194 - PubMed
  98. Blood. 2016 Nov 3;128(18):2206-2217 - PubMed
  99. Adv Mater. 2016 Oct;28(40):8912-8920 - PubMed
  100. J Control Release. 2016 Oct 10;239:137-48 - PubMed
  101. PLoS One. 2016 Sep 02;11(9):e0161955 - PubMed
  102. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6077-81 - PubMed
  103. Stem Cells Dev. 2017 Jan 1;26(1):25-34 - PubMed
  104. Gene Ther. 2017 Jan;24(1):31-39 - PubMed
  105. Cell Death Differ. 2017 Feb;24(2):357-370 - PubMed
  106. Nucleic Acids Res. 2017 Apr 20;45(7):4021-4035 - PubMed
  107. Cancer Lett. 2017 Mar 1;388:208-219 - PubMed
  108. Methods Mol Biol. 2017;1499:193-200 - PubMed
  109. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E448-E456 - PubMed
  110. RNA Biol. 2017 Mar 4;14(3):361-369 - PubMed
  111. Nano Lett. 2017 Feb 8;17(2):821-826 - PubMed
  112. Mol Ther. 2017 Feb 1;25(2):356-367 - PubMed
  113. Cell. 2017 Feb 9;168(4):724-740 - PubMed
  114. Genes (Basel). 2017 Feb 10;8(2): - PubMed
  115. Biomaterials. 2017 May;125:81-89 - PubMed
  116. Cancer Res. 2017 May 1;77(9):2339-2350 - PubMed
  117. Cell Res. 2017 May;27(5):626-641 - PubMed
  118. Mol Cell. 2017 Apr 6;66(1):9-21.e7 - PubMed
  119. Mol Cell. 2017 Apr 6;66(1):22-37.e9 - PubMed
  120. Mol Ther Methods Clin Dev. 2016 Dec 31;4:92-101 - PubMed
  121. Nat Nanotechnol. 2017 Aug;12(8):813-820 - PubMed
  122. J Clin Invest. 2017 Jun 1;127(6):2176-2191 - PubMed
  123. J Control Release. 2017 Jun 28;256:153-169 - PubMed
  124. Cancer Discov. 2017 Jul;7(7):656-657 - PubMed
  125. Mol Pharm. 2017 Jul 3;14(7):2422-2436 - PubMed
  126. Biomaterials. 2017 Sep;140:58-68 - PubMed
  127. Proc Natl Acad Sci U S A. 1979 Mar;76(3):1274-8 - PubMed
  128. Chem Rev. 2017 Aug 9;117(15):9874-9906 - PubMed
  129. Biomark Res. 2017 Jun 24;5:22 - PubMed
  130. Nat Commun. 2017 Jun 28;8:15939 - PubMed
  131. Adv Drug Deliv Rev. 2017 Jun 1;115:115-154 - PubMed
  132. Nucleic Acid Ther. 2017 Oct;27(5):251-259 - PubMed
  133. Hum Gene Ther. 2017 Oct;28(10):862-874 - PubMed
  134. Nat Rev Immunol. 2018 Mar;18(3):212-219 - PubMed
  135. Nat Commun. 2017 Aug 30;8(1):389 - PubMed
  136. Hum Gene Ther. 2017 Nov;28(11):1087-1104 - PubMed
  137. Trends Genet. 2017 Nov;33(11):852-870 - PubMed
  138. Chem Sci. 2017 Aug 1;8(8):5705-5712 - PubMed
  139. Biomaterials. 2018 Jan;150:162-170 - PubMed
  140. Biomacromolecules. 2017 Dec 11;18(12):3913-3923 - PubMed
  141. Biosci Rep. 2017 Dec 5;37(6):null - PubMed
  142. Cell. 2017 Dec 14;171(7):1471 - PubMed
  143. J Immunol. 2018 Feb 15;200(4):1255-1260 - PubMed
  144. Nat Biotechnol. 2018 Feb;36(2):160-169 - PubMed
  145. Adv Healthc Mater. 2018 Oct;7(20):e1701153 - PubMed
  146. Nat Nanotechnol. 2018 Mar;13(3):214-219 - PubMed
  147. Wiley Interdiscip Rev RNA. 2018 May;9(3):e1466 - PubMed
  148. Mol Ther. 2018 Apr 4;26(4):1137-1153 - PubMed
  149. J Control Release. 2018 Jul 28;282:140-147 - PubMed
  150. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4340-4344 - PubMed
  151. Proc Natl Acad Sci U S A. 2018 May 8;115(19):4903-4908 - PubMed
  152. Int J Mol Sci. 2018 Apr 27;19(5):null - PubMed
  153. Nat Med. 2018 May;24(5):563-571 - PubMed
  154. Drug Deliv. 2018 Nov;25(1):1234-1257 - PubMed
  155. Diseases. 2018 May 21;6(2):null - PubMed
  156. Blood. 2018 Sep 6;132(10):1022-1026 - PubMed
  157. Tissue Eng Part A. 2019 Jan;25(1-2):131-144 - PubMed
  158. ACS Omega. 2018 May 31;3(5):5273-5280 - PubMed
  159. Nat Rev Immunol. 2018 Oct;18(10):605-616 - PubMed
  160. Mol Cells. 2018 Aug 31;41(8):717-723 - PubMed
  161. Nano Lett. 2018 Nov 14;18(11):6655-6659 - PubMed
  162. Mol Ther Nucleic Acids. 2018 Sep 7;12:504-517 - PubMed
  163. Biomacromolecules. 2018 Nov 12;19(11):4193-4206 - PubMed
  164. EMBO Mol Med. 2018 Nov;10(11): - PubMed
  165. Gene Ther. 2018 Dec;25(8):556-567 - PubMed
  166. J Control Release. 2018 Dec 28;292:256-276 - PubMed
  167. Pharmaceuticals (Basel). 2018 Oct 18;11(4):null - PubMed
  168. J Am Chem Soc. 2018 Nov 28;140(47):16264-16274 - PubMed
  169. Sci Rep. 2018 Oct 24;8(1):15732 - PubMed
  170. J Biomed Mater Res B Appl Biomater. 2018 Nov 22;: - PubMed
  171. Biomacromolecules. 2019 Jan 14;20(1):435-442 - PubMed
  172. Front Immunol. 2018 Nov 28;9:2798 - PubMed
  173. Biomacromolecules. 2019 Feb 11;20(2):916-926 - PubMed
  174. Biomacromolecules. 2019 Feb 11;20(2):854-870 - PubMed
  175. Biomaterials. 2019 Mar;195:100-110 - PubMed
  176. Nat Nanotechnol. 2019 Mar;14(3):287-297 - PubMed
  177. N Engl J Med. 1988 Dec 22;319(25):1676-80 - PubMed
  178. J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Aug 1;9(4):349-58 - PubMed
  179. Immunity. 1995 Jul;3(1):39-50 - PubMed
  180. FASEB J. 1993 Aug;7(11):1061-9 - PubMed
  181. Gene Ther. 1997 Jan;4(1):45-54 - PubMed
  182. RNA. 1997 Jun;3(6):677-87 - PubMed
  183. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10122-7 - PubMed

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