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Schmidt-Malan SM, Brinkman CL, Karau MJ, et al. Effect of Direct Electrical Current on Bones Infected with . JBMR Plus. 2019;3(5):e10119doi: 10.1002/jbm4.10119.
Schmidt-Malan, S. M., Brinkman, C. L., Karau, M. J., Brown, R. A., Waletzki, B. E., Berglund, L. J., Schuetz, A. N., Greenwood-Quaintance, K. E., Mandrekar, J. N., & Patel, R. (2019). Effect of Direct Electrical Current on Bones Infected with . JBMR plus, 3(5), e10119. https://doi.org/10.1002/jbm4.10119
Schmidt-Malan, Suzannah M, et al. "Effect of Direct Electrical Current on Bones Infected with ." JBMR plus vol. 3,5 (2019): e10119. doi: https://doi.org/10.1002/jbm4.10119
Schmidt-Malan SM, Brinkman CL, Karau MJ, Brown RA, Waletzki BE, Berglund LJ, Schuetz AN, Greenwood-Quaintance KE, Mandrekar JN, Patel R. Effect of Direct Electrical Current on Bones Infected with . JBMR Plus. 2019 Jan 31;3(5):e10119. doi: 10.1002/jbm4.10119. eCollection 2019 May. PMID: 31131342; PMCID: PMC6524671.
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JBMR Plus. 2019 Jan 31;3(5):e10119. doi: 10.1002/jbm4.10119. eCollection 2019 May.

Effect of Direct Electrical Current on Bones Infected with .

JBMR plus

Suzannah M Schmidt-Malan, Cassandra L Brinkman, Melissa J Karau, Robert A Brown, Brian E Waletzki, Lawrence J Berglund, Audrey N Schuetz, Kerryl E Greenwood-Quaintance, Jayawant N Mandrekar, Robin Patel

Affiliations

  1. Division of Clinical Microbiology Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA.
  2. Biomaterials and Histomorphometry Core Laboratory Mayo Clinic Rochester MN USA.
  3. Biomechanics Research Core Laboratory Mayo Clinic Rochester MN USA.
  4. Division of Biomedical Statistics and Informatics Department of Health Sciences Research Mayo Clinic Rochester MN USA.
  5. Division of Infectious Diseases Department of Medicine Mayo Clinic Rochester MN USA.

PMID: 31131342 PMCID: PMC6524671 DOI: 10.1002/jbm4.10119

Abstract

We are developing electrical approaches to treat biofilm-associated orthopedic foreign-body infection. Although we have previously shown that such approaches have antibiofilm activity, the effects on bone have not been assessed. Herein, low-amperage 200 μA fixed direct current (DC) was compared with no current, in a rat femoral foreign-body infection model. In the infected group, a platinum implant seeded with

Keywords: ANTIBIOFILM ACTIVITY; BIOFILM; ELECTRICAL CURRENT; IMPLANT INFECTION

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