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J Am Acad Orthop Surg Glob Res Rev. 2019 Mar 05;3(3):e045. doi: 10.5435/JAAOSGlobal-D-17-00045. eCollection 2019 Mar.

Primary Bone Tumors in Children and Adolescents Treated at a Referral Center in Northern Tanzania.

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews

Michelle Ghert, Winfrida Mwita, Faiton Ndesanjo Mandari

Affiliations

  1. McMaster University, Hamilton, Ontario, Canada (Dr. Ghert), and the Kilimanjaro Christian Medical School, Moshi, Tanzania (Dr. Mwita and Dr. Mandari).

PMID: 31157317 PMCID: PMC6484668 DOI: 10.5435/JAAOSGlobal-D-17-00045

Abstract

Bone tumors account for a small fraction of childhood cancers. Most published reports are from developed countries. The purpose of this study was to review the primary bone tumors in children and adolescents treated at a referral center in Northern Tanzania. We completed a 10-year hospital-based cross-sectional study in which all patients younger than 20 years diagnosed with a primary bone tumor at the Kilimanjaro Christian Medical Center Orthopaedic Department from January 2006 to December 2015 were identified and reviewed. Of the 80 identified patients, 15 (18.8%) were aged 5 to 8 years, and 65 (81%) were aged 9 to 19 years. Forty-seven males (59%) and 33 females (41%) were identified. The most common tumor locations were the femur, tibia, and humerus. Osteosarcoma was the most common malignant diagnosis (49 patients, 61%). No cases of Ewing sarcoma were reported. The most common tribal origins of the patients were Chagga and Maasai. Most primary bone tumors treated at a referral center in Northern Tanzania are malignant, with osteosarcoma representing the vast majority. No cases of Ewing sarcoma were identified in this tertiary referral hospital-based database.

References

  1. Oncologist. 2006 May;11(5):503-19 - PubMed
  2. Gen Hosp Psychiatry. 2009 Jan-Feb;31(1):20-4 - PubMed
  3. Cancer. 2009 Aug 1;115(15):3526-36 - PubMed
  4. Afr J Med Med Sci. 2009 Mar;38(1):77-81 - PubMed
  5. Cancer Treat Res. 2009;152:3-13 - PubMed
  6. Malawi Med J. 2009 Jun;21(2):62-5 - PubMed
  7. Semin Pediatr Surg. 2012 May;21(2):136-41 - PubMed
  8. Clin Cases Miner Bone Metab. 2012 May;9(2):92-5 - PubMed
  9. PLoS One. 2014 Feb 21;9(2):e89102 - PubMed
  10. Cancer Epidemiol. 2015 Jun;39(3):298-302 - PubMed
  11. Arch Pathol Lab Med. 2015 Sep;139(9):1149-55 - PubMed
  12. Cancer Epidemiol. 2015 Aug;39(4):593-9 - PubMed
  13. Recent Results Cancer Res. 1973;41:222-33 - PubMed
  14. Int J Cancer. 1993 Feb 1;53(3):371-6 - PubMed
  15. Pediatr Pathol Lab Med. 1996 Sep-Oct;16(5):791-800 - PubMed

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