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Hodges EN, Mishin VP, De la Cruz J, et al. Detection of oseltamivir-resistant zoonotic and animal influenza A viruses using the rapid influenza antiviral resistance test. Influenza Other Respir Viruses. 2019;doi: 10.1111/irv.12661.
Hodges, E. N., Mishin, V. P., De la Cruz, J., Guo, Z., Nguyen, H. T., Fallows, E., Stevens, J., Wentworth, D. E., Davis, C. T., & Gubareva, L. V. (2019). Detection of oseltamivir-resistant zoonotic and animal influenza A viruses using the rapid influenza antiviral resistance test. Influenza and other respiratory viruses, . https://doi.org/10.1111/irv.12661
Hodges, Erin N, et al. "Detection of oseltamivir-resistant zoonotic and animal influenza A viruses using the rapid influenza antiviral resistance test." Influenza and other respiratory viruses vol. (2019). doi: https://doi.org/10.1111/irv.12661
Hodges EN, Mishin VP, De la Cruz J, Guo Z, Nguyen HT, Fallows E, Stevens J, Wentworth DE, Davis CT, Gubareva LV. Detection of oseltamivir-resistant zoonotic and animal influenza A viruses using the rapid influenza antiviral resistance test. Influenza Other Respir Viruses. 2019 Jun 11; doi: 10.1111/irv.12661. Epub 2019 Jun 11. PMID: 31187572; PMCID: PMC6692545.
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Influenza Other Respir Viruses. 2019 Jun 11; doi: 10.1111/irv.12661. Epub 2019 Jun 11.

Detection of oseltamivir-resistant zoonotic and animal influenza A viruses using the rapid influenza antiviral resistance test.

Influenza and other respiratory viruses

Erin N Hodges, Vasiliy P Mishin, Juan De la Cruz, Zhu Guo, Ha T Nguyen, Eric Fallows, James Stevens, David E Wentworth, Charles Todd Davis, Larisa V Gubareva

Affiliations

  1. Influenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
  2. CNI Advantage, Atlanta, Georgia.
  3. Battelle Memorial Institute, Atlanta, Georgia.
  4. Becton, Dickinson and Company, Research Triangle Park, North Carolina.

PMID: 31187572 PMCID: PMC6692545 DOI: 10.1111/irv.12661

Abstract

Mutations in the influenza virus neuraminidase (NA) that cause reduced susceptibility to the NA inhibitor (NAI) oseltamivir may occur naturally or following antiviral treatment. Currently, detection uses either a traditional NA inhibition assay or gene sequencing to identify known markers associated with reduced inhibition by oseltamivir. Both methods are laborious and require trained personnel. The influenza antiviral resistance test (iART), a prototype system developed by Becton, Dickinson and Company for research use only, offers a rapid and simple method to identify such viruses. This study investigated application of iART to influenza A viruses isolated from non-human hosts with a variety of NA subtypes (N1-N9).

© 2019 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

Keywords: antiviral drugs; avian; influenza A virus; resistance; zoonotic

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