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Ali SM, Khan NA, Sagathevan K, et al. Biologically active metabolite(s) from haemolymph of red-headed centipede Scolopendra subspinipes possess broad spectrum antibacterial activity. AMB Express. 2019;9(1):95doi: 10.1186/s13568-019-0816-3.
Ali, S. M., Khan, N. A., Sagathevan, K., Anwar, A., & Siddiqui, R. (2019). Biologically active metabolite(s) from haemolymph of red-headed centipede Scolopendra subspinipes possess broad spectrum antibacterial activity. AMB Express, 9(1), 95. https://doi.org/10.1186/s13568-019-0816-3
Ali, Salwa Mansur, et al. "Biologically active metabolite(s) from haemolymph of red-headed centipede Scolopendra subspinipes possess broad spectrum antibacterial activity." AMB Express vol. 9,1 (2019): 95. doi: https://doi.org/10.1186/s13568-019-0816-3
Ali SM, Khan NA, Sagathevan K, Anwar A, Siddiqui R. Biologically active metabolite(s) from haemolymph of red-headed centipede Scolopendra subspinipes possess broad spectrum antibacterial activity. AMB Express. 2019 Jun 28;9(1):95. doi: 10.1186/s13568-019-0816-3. PMID: 31254123; PMCID: PMC6598926.
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AMB Express. 2019 Jun 28;9(1):95. doi: 10.1186/s13568-019-0816-3.

Biologically active metabolite(s) from haemolymph of red-headed centipede Scolopendra subspinipes possess broad spectrum antibacterial activity.

AMB Express

Salwa Mansur Ali, Naveed Ahmed Khan, K Sagathevan, Ayaz Anwar, Ruqaiyyah Siddiqui

Affiliations

  1. Department of Biological Sciences, School of Science and Technology, Sunway University, 47500, Subang Jaya, Selangor, Malaysia.
  2. Department of Biological Sciences, School of Science and Technology, Sunway University, 47500, Subang Jaya, Selangor, Malaysia. [email protected].

PMID: 31254123 PMCID: PMC6598926 DOI: 10.1186/s13568-019-0816-3

Abstract

The discovery of novel antimicrobials from animal species under pollution is an area untapped. Chinese red-headed centipede is one of the hardiest arthropod species commonly known for its therapeutic value in traditional Chinese medicine. Here we determined the antibacterial activity of haemolymph and tissue extracts of red-headed centipede, Scolopendra subspinipes against a panel of Gram-positive and Gram-negative bacteria. Lysates exhibited potent antibacterial activities against a broad range of bacteria tested. Chemical characterization of biologically active molecules was determined via liquid chromatography mass spectrometric analysis. From crude haemolymph extract, 12 compounds were identified including: (1) L-Homotyrosine, (2) 8-Acetoxy-4-acoren-3-one, (3) N-Undecylbenzenesulfonic acid, (4) 2-Dodecylbenzenesulfonic acid, (5) 3H-1,2-Dithiole-3-thione, (6) Acetylenedicarboxylate, (7) Albuterol, (8) Tetradecylamine, (9) Curcumenol, (10) 3-Butylidene-7-hydroxyphthalide, (11) Oleoyl Ethanolamide and (12) Docosanedioic acid. Antimicrobial activities of the identified compounds were reported against Gram-positive and Gram-negative bacteria, fungi, viruses and parasites, that possibly explain centipede's survival in harsh and polluted environments. Further research in characterization, molecular mechanism of action and in vivo testing of active molecules is needed for the development of novel antibacterials.

Keywords: Antibacterials; Centipede; Superbugs

References

  1. J Agric Food Chem. 1999 Oct;47(10):4297-300 - PubMed
  2. Nat Struct Biol. 2000 Mar;7(3):189-90 - PubMed
  3. Bioorg Med Chem. 2000 Jul;8(7):1677-96 - PubMed
  4. Wilderness Environ Med. 2001 Summer;12(2):93-9 - PubMed
  5. Mol Med. 2001 Feb;7(2):135-45 - PubMed
  6. J Nat Prod. 2001 Nov;64(11):1444-6 - PubMed
  7. J Laryngol Otol. 2002 Jan;116(1):70-2 - PubMed
  8. Neuropsychopharmacology. 2003 Jul;28(7):1311-6 - PubMed
  9. Nature. 1953 Feb 21;171(4347):343 - PubMed
  10. Nature. 1955 Mar 26;175(4456):548 - PubMed
  11. Biochem Biophys Res Commun. 1992 Oct 30;188(2):624-30 - PubMed
  12. J Med Chem. 1992 Jul 24;35(15):2843-55 - PubMed
  13. Nat Prod Rep. 2004 Feb;21(1):143-63 - PubMed
  14. Farmaco. 2004 Apr;59(4):245-54 - PubMed
  15. J Nat Prod. 2006 Apr;69(4):536-41 - PubMed
  16. Indian J Biochem Biophys. 2006 Apr;43(2):88-93 - PubMed
  17. J Antimicrob Chemother. 2008 Sep;62(3):634-5 - PubMed
  18. Carcinogenesis. 2009 Mar;30(3):480-6 - PubMed
  19. Neurochem Res. 2009 Nov;34(11):1924-34 - PubMed
  20. Int J Parasitol. 2009 Dec;39(14):1611-6 - PubMed
  21. Toxicon. 2010 Feb-Mar;55(2-3):274-9 - PubMed
  22. Clin Exp Pharmacol Physiol. 2010 Apr;37(4):482-9 - PubMed
  23. Toxicon. 2011 Mar 15;57(4):512-24 - PubMed
  24. Int J Antimicrob Agents. 2011 Mar;37(3):279-80 - PubMed
  25. Bioorg Med Chem. 2011 Mar 15;19(6):2046-54 - PubMed
  26. J Med Chem. 2012 Feb 9;55(3):1147-60 - PubMed
  27. Mol Pharmacol. 2012 Jul;82(1):27-36 - PubMed
  28. Bioorg Med Chem. 2013 Mar 1;21(5):1305-11 - PubMed
  29. Colloids Surf B Biointerfaces. 2013 Oct 1;110:387-94 - PubMed
  30. Biochim Biophys Acta. 2013 Nov;1828(11):2745-50 - PubMed
  31. Skeletal Radiol. 2014 May;43(5):577-89 - PubMed
  32. Biomed Chromatogr. 2015 Jun;29(6):890-901 - PubMed
  33. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5829-5831 - PubMed
  34. Nat Rev Drug Discov. 2015 Feb;14(2):111-29 - PubMed
  35. Neurochem Res. 2016 Mar;41(3):523-33 - PubMed
  36. Ann N Y Acad Sci. 2015 Sep;1354:82-97 - PubMed
  37. J Microbiol. 2015 Dec;53(12):847-55 - PubMed
  38. Fitoterapia. 2016 Apr;110:103-9 - PubMed
  39. Brain Behav Immun. 2016 Oct;57:173-186 - PubMed
  40. Molecules. 2016 Apr 26;21(5): - PubMed
  41. J Enzyme Inhib Med Chem. 2016;31(sup1):89-97 - PubMed
  42. Int J Antimicrob Agents. 2016 Sep;48(3):277-85 - PubMed
  43. Appl Microbiol Biotechnol. 2017 Jan;101(1):253-286 - PubMed
  44. J Microbiol Biotechnol. 2017 Jan 28;27(1):43-48 - PubMed
  45. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5960-5966 - PubMed
  46. Eur J Pharmacol. 2017 Jan 15;795:115-123 - PubMed
  47. J Tradit Complement Med. 2016 Feb 16;7(1):24-29 - PubMed
  48. J Immunol Res. 2016;2016:7521601 - PubMed
  49. Brain Behav Immun. 2017 May;62:180-192 - PubMed
  50. Br J Pharmacol. 2017 May;174(9):796-808 - PubMed
  51. Pharmacol Res. 2017 May;119:227-236 - PubMed
  52. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1346-1350 - PubMed
  53. Front Microbiol. 2017 Mar 28;8:552 - PubMed
  54. J Biol Chem. 2017 Aug 25;292(34):14108-14121 - PubMed
  55. Sci Rep. 2017 Jul 14;7(1):5504 - PubMed
  56. BMC Vet Res. 2017 Aug 2;13(1):229 - PubMed
  57. Br J Pharmacol. 2017 Nov;174(21):3780-3789 - PubMed
  58. Br J Pharmacol. 2017 Nov;174(21):3837-3847 - PubMed
  59. Acta Pharmacol Sin. 2018 Jun;39(6):975-987 - PubMed
  60. J Sep Sci. 2017 Nov;40(22):4311-4319 - PubMed
  61. Eur Respir J. 2017 Sep 20;50(3): - PubMed
  62. Bioorg Med Chem. 2017 Oct 15;25(20):5764-5771 - PubMed
  63. Food Funct. 2017 Oct 18;8(10):3707-3722 - PubMed
  64. J Ethnopharmacol. 2018 Mar 1;213:48-55 - PubMed
  65. Mol Med Rep. 2018 Feb;17(2):2515-2522 - PubMed
  66. Methods Mol Biol. 2018;1727:155-166 - PubMed
  67. Bioorg Med Chem Lett. 2018 Feb 1;28(3):410-414 - PubMed
  68. Lancet Infect Dis. 2018 Mar;18(3):318-327 - PubMed
  69. Bioorg Med Chem. 2018 Feb 1;26(3):573-580 - PubMed
  70. Nat Prod Res. 2018 Nov;32(21):2499-2504 - PubMed
  71. Nat Prod Res. 2019 Jun;33(12):1804-1808 - PubMed
  72. J Physiol Biochem. 2018 May;74(2):261-272 - PubMed
  73. J Med Chem. 2018 Apr 12;61(7):2865-2874 - PubMed
  74. Infect Drug Resist. 2018 Apr 09;11:501-514 - PubMed
  75. Chem Biol Drug Des. 2018 Aug;92(2):1576-1580 - PubMed
  76. Eur J Med Chem. 2018 May 10;151:824-835 - PubMed
  77. J Proteomics. 2018 Jun 30;182:1-11 - PubMed
  78. J Nat Prod. 2018 Jun 22;81(6):1391-1398 - PubMed
  79. J Pharmacol Exp Ther. 2018 Aug;366(2):377-389 - PubMed
  80. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:220-227 - PubMed
  81. Biochem Pharmacol. 2018 Sep;155:82-91 - PubMed
  82. Arch Pharm Res. 2018 Oct;41(10):977-985 - PubMed
  83. Neuropharmacology. 2018 Oct;141:55-65 - PubMed
  84. J Pharm Biomed Anal. 2018 Oct 25;160:415-427 - PubMed
  85. Mol Biol Rep. 2018 Dec;45(6):1919-1927 - PubMed
  86. Prostaglandins Other Lipid Mediat. 2018 Nov;139:54-62 - PubMed
  87. Br J Pharmacol. 2018 Dec;175(24):4464-4479 - PubMed
  88. Psychopharmacology (Berl). 2018 Nov;235(11):3211-3221 - PubMed
  89. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3436-3440 - PubMed
  90. Bioorg Chem. 2019 Feb;82:26-32 - PubMed
  91. Front Microbiol. 2018 Sep 28;9:2249 - PubMed
  92. Life Sci. 2018 Nov 15;213:74-81 - PubMed
  93. Drug Metabol Drug Interact. 1988;6(3-4):183-202 - PubMed
  94. Biochemistry. 1985 Jun 18;24(13):3158-65 - PubMed
  95. Annu Rev Microbiol. 1980;34:537-57 - PubMed
  96. Rev Infect Dis. 1980 Jan-Feb;2(1):129-39 - PubMed

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