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Weis E, Vrouwe SQ, LeBaron DB, et al. Changes in Ultraviolet Radiation Exposure to the Ocular Region: A Population-Based Study. Cancers (Basel). 2019;11(5)doi: 10.3390/cancers11050719.
Weis, E., Vrouwe, S. Q., LeBaron, D. B., Parliament, M. B., Shields, J., & Shields, C. L. (2019). Changes in Ultraviolet Radiation Exposure to the Ocular Region: A Population-Based Study. Cancers, 11(5), . https://doi.org/10.3390/cancers11050719
Weis, Ezekiel, et al. "Changes in Ultraviolet Radiation Exposure to the Ocular Region: A Population-Based Study." Cancers vol. 11,5 (2019). doi: https://doi.org/10.3390/cancers11050719
Weis E, Vrouwe SQ, LeBaron DB, Parliament MB, Shields J, Shields CL. Changes in Ultraviolet Radiation Exposure to the Ocular Region: A Population-Based Study. Cancers (Basel). 2019 May 24;11(5). doi: 10.3390/cancers11050719. PMID: 31137687; PMCID: PMC6562648.
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Cancers (Basel). 2019 May 24;11(5). doi: 10.3390/cancers11050719.

Changes in Ultraviolet Radiation Exposure to the Ocular Region: A Population-Based Study.

Cancers

Ezekiel Weis, Sebastian Q Vrouwe, David B LeBaron, Matthew B Parliament, Jerry Shields, Carol L Shields

Affiliations

  1. Department of Ophthalmology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T5H 3V9, Canada. [email protected].
  2. Division of Ophthalmology, Department of Surgery, University of Calgary, Calgary, AB T2V 4R6, Canada. [email protected].
  3. Department of Ophthalmology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T5H 3V9, Canada. [email protected].
  4. Department of Ophthalmology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T5H 3V9, Canada. [email protected].
  5. Division of Radiation Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 1Z2, Canada. [email protected].
  6. Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA. [email protected].
  7. Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA. [email protected].

PMID: 31137687 PMCID: PMC6562648 DOI: 10.3390/cancers11050719

Abstract

In contrast to the well-established association between ultraviolet radiation (UVR) exposure and skin cancers, the relationship between UVR and uveal malignant melanoma (UM) remains controversial. To address this controversy, we evaluated the incidence rates of cutaneous malignancies in the eyelids as a proxy for UVR exposure in the ocular region using a population-based cancer registry. Overall, 74,053 cases of eyelid basal cell carcinoma (BCC) and 7890 cases of melanoma over a 26-year period (1982-2007) were analyzed. The incidence of eyelid basal cell carcinoma and uveal melanoma remained stable, whereas other cutaneous areas demonstrated an increase in the rates. A comparability test demonstrated that BCC incidence trends were significantly different between the eyelid versus both chronically exposed (males

Keywords: basal cell carcinoma; cutaneous melanoma; eye exposure; ocular tumors; skin cancer; ultraviolet radiation; uveal melanoma

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