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Severino P, Netti L, Mariani MV, et al. Prevention of Cardiovascular Disease: Screening for Magnesium Deficiency. Cardiol Res Pract. 2019;2019:4874921doi: 10.1155/2019/4874921.
Severino, P., Netti, L., Mariani, M. V., Maraone, A., D'Amato, A., Scarpati, R., Infusino, F., Pucci, M., Lavalle, C., Maestrini, V., Mancone, M., & Fedele, F. (2019). Prevention of Cardiovascular Disease: Screening for Magnesium Deficiency. Cardiology research and practice, 20194874921. https://doi.org/10.1155/2019/4874921
Severino, Paolo, et al. "Prevention of Cardiovascular Disease: Screening for Magnesium Deficiency." Cardiology research and practice vol. 2019 (2019): 4874921. doi: https://doi.org/10.1155/2019/4874921
Severino P, Netti L, Mariani MV, Maraone A, D'Amato A, Scarpati R, Infusino F, Pucci M, Lavalle C, Maestrini V, Mancone M, Fedele F. Prevention of Cardiovascular Disease: Screening for Magnesium Deficiency. Cardiol Res Pract. 2019 May 02;2019:4874921. doi: 10.1155/2019/4874921. eCollection 2019. PMID: 31192005; PMCID: PMC6525869.
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Cardiol Res Pract. 2019 May 02;2019:4874921. doi: 10.1155/2019/4874921. eCollection 2019.

Prevention of Cardiovascular Disease: Screening for Magnesium Deficiency.

Cardiology research and practice

Paolo Severino, Lucrezia Netti, Marco Valerio Mariani, Annalisa Maraone, Andrea D'Amato, Rossana Scarpati, Fabio Infusino, Mariateresa Pucci, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, Francesco Fedele

Affiliations

  1. Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
  2. Department of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy.

PMID: 31192005 PMCID: PMC6525869 DOI: 10.1155/2019/4874921

Abstract

Magnesium is an essential mineral naturally present in the human body, where it acts as cofactor in several enzymatic reactions. Magnesium is a key cardiovascular regulator, which maintains electrical, metabolic, and vascular homeostasis. Moreover, magnesium participates in inflammation and oxidative processes. In fact, magnesium deficiency is involved in the pathophysiology of arterial hypertension, diabetes mellitus, dyslipidemia, metabolic syndrome, endothelial dysfunction, coronary artery disease, cardiac arrhythmias, and sudden cardiac death. In consideration of the great public-health impact of cardiovascular disease, the recognition of the negative effects of magnesium deficiency suggests the possible role of hypomagnesaemia as cardiovascular risk factor and the use of serum magnesium level for the screening and prevention of cardiovascular risk factors and cardiovascular diseases. Moreover, it might help with the identification of new therapeutical strategies for the management of cardiovascular disease through magnesium supplementation.

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