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Cell Stress. 2018 Sep 10;2(9):219-224. doi: 10.15698/cst2018.09.151.

Unweaving the role of nuclear Lamins in neural circuit integrity.

Cell stress

Samantha L Deal, Shinya Yamamoto

Affiliations

  1. Program in Developmental Biology, Baylor College of Medicine (BCM), Houston, TX 77030.
  2. Department of Molecular and Human Genetics, BCM, Houston, TX 77030.
  3. Department of Neuroscience, BCM, Houston, TX 77030.
  4. Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX.

PMID: 31223139 PMCID: PMC6558928 DOI: 10.15698/cst2018.09.151

Abstract

Lamins are type-V intermediate filament proteins that comprise the nuclear lamina. Although once considered static structural components that provide physical support to the inner nuclear envelope, recent studies are revealing additional functional and regulatory roles for Lamins in chromatin organization, gene regulation, DNA repair, cell division and signal transduction. In this issue of

Keywords: Drosophila; Lamin; dopaminergic neuron; giant fiber circuit; neurodegeneration

Conflict of interest statement

Conflict of interest: The authors have no conflict of interest to declare.

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