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Cortez MM, Rae N, Millsap L, et al. Pupil Cycle Time Distinguishes Migraineurs From Subjects Without Headache. Front Neurol. 2019;10:478doi: 10.3389/fneur.2019.00478.
Cortez, M. M., Rae, N., Millsap, L., McKean, N., & Brennan, K. C. (2019). Pupil Cycle Time Distinguishes Migraineurs From Subjects Without Headache. Frontiers in neurology, 10478. https://doi.org/10.3389/fneur.2019.00478
Cortez, Melissa M, et al. "Pupil Cycle Time Distinguishes Migraineurs From Subjects Without Headache." Frontiers in neurology vol. 10 (2019): 478. doi: https://doi.org/10.3389/fneur.2019.00478
Cortez MM, Rae N, Millsap L, McKean N, Brennan KC. Pupil Cycle Time Distinguishes Migraineurs From Subjects Without Headache. Front Neurol. 2019 May 08;10:478. doi: 10.3389/fneur.2019.00478. eCollection 2019. PMID: 31139137; PMCID: PMC6518457.
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Front Neurol. 2019 May 08;10:478. doi: 10.3389/fneur.2019.00478. eCollection 2019.

Pupil Cycle Time Distinguishes Migraineurs From Subjects Without Headache.

Frontiers in neurology

Melissa M Cortez, Natalie Rae, Leah Millsap, Nick McKean, K C Brennan

Affiliations

  1. Department of Neurology, University of Utah, Salt Lake City, UT, United States.
  2. School of Medicine, University of Utah, Salt Lake City, UT, United States.

PMID: 31139137 PMCID: PMC6518457 DOI: 10.3389/fneur.2019.00478

Abstract

Migraine is a neurological disorder characterized by paroxysms of head pain accompanied by trigeminovascular system activation and autonomic dysfunction. Diagnosis is currently based on clinical diagnostic criteria. Though physiological differences exist between migraineurs and non-headache controls, true physiological biomarkers have been elusive, especially for the full clinical spectrum of migraine, inclusive of chronic, episodic, and probable migraine. We used edge-light pupil cycle time (PCT) as a probe of the pupillary light circuit in migraine, paired with clinical assessment of migraine characteristics, and compared these to non-headache controls. We found significantly increased PCT in probable, episodic, and chronic migraine, compared to controls. Additionally, increased PCT correlated with the presence of craniofacial autonomic symptoms, linking pupillary circuit dysfunction to peripheral trigeminal sensitization. The sensitivity of PCT, especially for all severities of disease, distinguishes it from other physiological phenotypes, which may make it useful as a potential biomarker.

Keywords: central sensititization; craniofacial autonomic symptoms; migraine; pupil cycle time; trigeminal sensitization

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