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Anand K, Roszik J, Gombos D, et al. Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma. Cancers (Basel). 2019;11(6)doi: 10.3390/cancers11060856.
Anand, K., Roszik, J., Gombos, D., Upshaw, J., Sarli, V., Meas, S., Lucci, A., Hall, C., & Patel, S. (2019). Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma. Cancers, 11(6), . https://doi.org/10.3390/cancers11060856
Anand, Kartik, et al. "Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma." Cancers vol. 11,6 (2019). doi: https://doi.org/10.3390/cancers11060856
Anand K, Roszik J, Gombos D, Upshaw J, Sarli V, Meas S, Lucci A, Hall C, Patel S. Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma. Cancers (Basel). 2019 Jun 20;11(6). doi: 10.3390/cancers11060856. PMID: 31226786; PMCID: PMC6628316.
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Cancers (Basel). 2019 Jun 20;11(6). doi: 10.3390/cancers11060856.

Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma.

Cancers

Kartik Anand, Jason Roszik, Dan Gombos, Joshua Upshaw, Vanessa Sarli, Salyna Meas, Anthony Lucci, Carolyn Hall, Sapna Patel

Affiliations

  1. Houston Methodist Cancer Center, Houston, TX 77030, USA. [email protected].
  2. Department of Melanoma Medical Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA. [email protected].
  3. Department of Head and Neck Surgery, Section of Ophthalmology, UT MD Anderson Cancer Center, Houston, TX 77030, USA. [email protected].
  4. Department of Surgical Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA. [email protected].
  5. Department of Surgical Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA. [email protected].
  6. Department of Surgical Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA. [email protected].
  7. Department of Surgical Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA. [email protected].
  8. Department of Surgical Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA. [email protected].
  9. Department of Melanoma Medical Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA. [email protected].

PMID: 31226786 PMCID: PMC6628316 DOI: 10.3390/cancers11060856

Abstract

Nearly 50% of uveal melanoma (UM) patients develop metastatic disease, and there remains no current standard assay for detection of minimal residual disease. We conducted a pilot study to check the feasibility of circulating tumor cell (CTC) detection in UM. We enrolled 40 patients with early or metastatic UM of which 20 patients had early-stage disease, 19 had metastatic disease, and one was not evaluable. At initial blood draw, 36% of patients had detectable CTCs (30% in early-stage vs. 42% in metastatic), which increased to 54% at data cutoff (40% in early-stage vs. 68% in metastatic). Five early-stage patients developed distant metastases, 60% (3/5) had detectable CTCs before radiographic detection of the metastasis. Landmark overall survival (from study enrollment) at 24 months was statistically lower in CTC-positive vs. negative early-stage UM (

Keywords: circulating tumor cells; liquid biopsy; pilot study; uveal melanoma

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