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Biomed Opt Express. 2019 May 30;10(6):3070-3091. doi: 10.1364/BOE.10.003070. eCollection 2019 Jun 01.

[No title available]

Biomedical optics express

Fabio Feroldi, Joy Willemse, Valentina Davidoiu, Maximilian G O Gräfe, Dirck J van Iperen, Annika W M Goorsenberg, Jouke T Annema, Johannes M A Daniels, Peter I Bonta, Johannes F de Boer

Affiliations

  1. LaserLaB Amsterdam and Department of Physics and Astronomy, VU University Amsterdam, de Boelelaan 1081, 1081HV, Amsterdam, the Netherlands.
  2. These authors contributed equally.
  3. Amsterdam University Medical Center, Department of Pulmonology, University of Amsterdam, Amsterdam, the Netherlands.
  4. Amsterdam University Medical Center, Department of Pulmonology, VUmc Location, Amsterdam, the Netherlands.

PMID: 31259075 PMCID: PMC6583343 DOI: 10.1364/BOE.10.003070

Abstract

Remodeling of tissue, such as airway smooth muscle (ASM) and extracellular matrix, is considered a key feature of airways disease. No clinically accepted diagnostic method is currently available to assess airway remodeling or the effect of treatment modalities such as bronchial thermoplasty in asthma, other than invasive airway biopsies. Optical coherence tomography (OCT) generates cross-sectional, near-histological images of airway segments and enables identification and quantification of airway wall layers based on light scattering properties only. In this study, we used a custom motorized OCT probe that combines standard and polarization sensitive OCT (PS-OCT) to visualize birefringent tissue

Conflict of interest statement

The authors declare that there are no conflicts of interest related to this article.

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