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Cao BL, Yao Y, Xu YX, et al. The Relationship Between β-cell Function Indices and Sudomotor Function in Chinese Patients with Type 2 Diabetes. Exp Clin Endocrinol Diabetes. 2019;129(8):553-559doi: 10.1055/a-0950-9828.
Cao, B. L., Yao, Y., Xu, Y. X., Fang, J., Song, W. J., Hu, B., Guo, Q. Y., Lu, B., Li, J., Gu, P., & Shao, J. Q. (2021). The Relationship Between β-cell Function Indices and Sudomotor Function in Chinese Patients with Type 2 Diabetes. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 129(8), 553-559. https://doi.org/10.1055/a-0950-9828
Cao, Bai-Lu, et al. "The Relationship Between β-cell Function Indices and Sudomotor Function in Chinese Patients with Type 2 Diabetes." Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association vol. 129,8 (2021): 553-559. doi: https://doi.org/10.1055/a-0950-9828
Cao BL, Yao Y, Xu YX, Fang J, Song WJ, Hu B, Guo QY, Lu B, Li J, Gu P, Shao JQ. The Relationship Between β-cell Function Indices and Sudomotor Function in Chinese Patients with Type 2 Diabetes. Exp Clin Endocrinol Diabetes. 2021 Aug;129(8):553-559. doi: 10.1055/a-0950-9828. Epub 2019 Jul 03. PMID: 31269513.
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Exp Clin Endocrinol Diabetes. 2021 Aug;129(8):553-559. doi: 10.1055/a-0950-9828. Epub 2019 Jul 03.

The Relationship Between β-cell Function Indices and Sudomotor Function in Chinese Patients with Type 2 Diabetes.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

Bai-Lu Cao, Yue Yao, Yi-Xin Xu, Jiang Fang, Wen-Jing Song, Bin Hu, Qing-Yu Guo, Bin Lu, Jie Li, Ping Gu, Jia-Qing Shao

Affiliations

  1. Department of Endocrinology, the affiliated Jinling Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
  2. Department of Endocrinology, Jinling Hospital, Nanjing University, Nanjing, Jiangsu, China.
  3. Department of Neurosurgery, Jinling Hospital, Southeast University, Nanjing, Jiangsu, China.
  4. Department of Endocrinology, Jinling Hospital, Southern Medical University, Nanjing, Jiangsu, China.

PMID: 31269513 DOI: 10.1055/a-0950-9828

Abstract

PURPOSE: SUDOSCAN, a new non-invasive, quick, sensitive and quantitative technique, has been developed to detect diabetic peripheral neuropathy, and the latter is believed to be correlated with impaired β-cell function. The purpose of the present study was to investigate the associations between β-cell function indices and sudomotor function in Chinese type 2 diabetes.

METHODS: A total of 266 Chinese patients with type 2 diabetes were enrolled. Sudomotor function was assessed using electrochemical skin conductance of hands and feet. Pancreatic β-cell function was determined by homeostasis model assessment of β-cell function index, early-phase β-cell function indices and total β-cell function indices. Pearson correlation analysis and multiple linear stepwise regression analysis were carried out to explore the associations between β-cell function indices and sudomotor function.

RESULTS: Patients with lower early-phase β-cell function had lower electrochemical skin conductance levels of hands and feet and higher asymmetry ratio of hands and feet. Both Pearson correlation analysis and multiple linear stepwise regression analysis showed significantly positive relationships between early-phase β-cell function and electrochemical skin conductance levels of hands and feet, after controlling for potential confounders (P<0.05).

CONCLUSIONS: Impaired early-phase β-cell function was positively associated with sudomotor dysfunction in Chinese patients with type 2 diabetes. We speculated that impaired early-phase β-cell function may be associated with the incidence of sudomotor dysfunction in patients with T2DM.

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Conflict of interest statement

All authors declare that they have no conflict of interest.

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