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Cheaveau J, Marasinghe D, Akakpo S, et al. The Impact of Malaria on Liver Enzymes: A Retrospective Cohort Study (2010-2017). Open Forum Infect Dis. 2019;6(6):ofz234doi: 10.1093/ofid/ofz234.
Cheaveau, J., Marasinghe, D., Akakpo, S., Deardon, R., Naugler, C., Chin, A., & Pillai, D. R. (2019). The Impact of Malaria on Liver Enzymes: A Retrospective Cohort Study (2010-2017). Open forum infectious diseases, 6(6), ofz234. https://doi.org/10.1093/ofid/ofz234
Cheaveau, James, et al. "The Impact of Malaria on Liver Enzymes: A Retrospective Cohort Study (2010-2017)." Open forum infectious diseases vol. 6,6 (2019): ofz234. doi: https://doi.org/10.1093/ofid/ofz234
Cheaveau J, Marasinghe D, Akakpo S, Deardon R, Naugler C, Chin A, Pillai DR. The Impact of Malaria on Liver Enzymes: A Retrospective Cohort Study (2010-2017). Open Forum Infect Dis. 2019 May 16;6(6):ofz234. doi: 10.1093/ofid/ofz234. eCollection 2019 Jun. PMID: 31263731; PMCID: PMC6592410.
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Open Forum Infect Dis. 2019 May 16;6(6):ofz234. doi: 10.1093/ofid/ofz234. eCollection 2019 Jun.

The Impact of Malaria on Liver Enzymes: A Retrospective Cohort Study (2010-2017).

Open forum infectious diseases

James Cheaveau, Dewdunee Marasinghe, Samantha Akakpo, Rob Deardon, Christopher Naugler, Alex Chin, Dylan R Pillai

Affiliations

  1. Department of Microbiology, Immunology, and Infectious Diseases, University of Calgary, AB, Canada.
  2. Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, PQ, Canada.
  3. United Biosource Corporation, Geneva, Switzerland.
  4. Department of Mathematics and Statistics, University of Calgary, AB, Canada.
  5. Calgary Laboratory Services, Calgary, AB, Canada.
  6. Department of Pathology and Laboratory Medicine, University of Calgary, AB, Canada.

PMID: 31263731 PMCID: PMC6592410 DOI: 10.1093/ofid/ofz234

Abstract

BACKGROUND: It is unclear if malaria causes deranged liver enzymes. This has implications both in clinical practice and in research, particularly for antimalarial drug development.

METHOD: We performed a retrospective cohort study of returning travelers (n = 4548) who underwent a malaria test and had enzymes measured within 31 days in Calgary, Canada, from 2010 to 2017. Odds ratios of having an abnormal alkaline phosphatase (ALP), alanine aminotransferases (ALT), aspartate aminotransferases (AST), and total bilirubin (TB) were calculated using multivariable longitudinal analysis with binomial response.

RESULTS: After adjusting for gender, age, and use of hepatotoxic medications, returning travelers testing positive for malaria had higher odds of having an abnormal TB (odds ratio [OR], 12.64; 95% confidence interval [CI], 6.32-25.29;

CONCLUSIONS: In malaria-exposed returning travelers, the TB is abnormal, especially in the early period, but no abnormalities are seen for ALT, AST, or ALP.

Keywords: clinical trials; liver enzymes; malaria

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