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Negash AA, Asrat D, Abebe W, et al. Pneumococcal Carriage, Serotype Distribution, and Risk Factors in Children With Community-Acquired Pneumonia, 5 Years After Introduction of the 10-Valent Pneumococcal Conjugate Vaccine in Ethiopia. Open Forum Infect Dis. 2019;6(6):ofz259doi: 10.1093/ofid/ofz259.
Negash, A. A., Asrat, D., Abebe, W., Hailemariam, T., Gebre, M., Verhaegen, J., Aseffa, A., & Vaneechoutte, M. (2019). Pneumococcal Carriage, Serotype Distribution, and Risk Factors in Children With Community-Acquired Pneumonia, 5 Years After Introduction of the 10-Valent Pneumococcal Conjugate Vaccine in Ethiopia. Open forum infectious diseases, 6(6), ofz259. https://doi.org/10.1093/ofid/ofz259
Negash, Abel Abera, et al. "Pneumococcal Carriage, Serotype Distribution, and Risk Factors in Children With Community-Acquired Pneumonia, 5 Years After Introduction of the 10-Valent Pneumococcal Conjugate Vaccine in Ethiopia." Open forum infectious diseases vol. 6,6 (2019): ofz259. doi: https://doi.org/10.1093/ofid/ofz259
Negash AA, Asrat D, Abebe W, Hailemariam T, Gebre M, Verhaegen J, Aseffa A, Vaneechoutte M. Pneumococcal Carriage, Serotype Distribution, and Risk Factors in Children With Community-Acquired Pneumonia, 5 Years After Introduction of the 10-Valent Pneumococcal Conjugate Vaccine in Ethiopia. Open Forum Infect Dis. 2019 May 31;6(6):ofz259. doi: 10.1093/ofid/ofz259. eCollection 2019 Jun. PMID: 31263735; PMCID: PMC6592415.
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Open Forum Infect Dis. 2019 May 31;6(6):ofz259. doi: 10.1093/ofid/ofz259. eCollection 2019 Jun.

Pneumococcal Carriage, Serotype Distribution, and Risk Factors in Children With Community-Acquired Pneumonia, 5 Years After Introduction of the 10-Valent Pneumococcal Conjugate Vaccine in Ethiopia.

Open forum infectious diseases

Abel Abera Negash, Daniel Asrat, Workeabeba Abebe, Tewodros Hailemariam, Meseret Gebre, Jan Verhaegen, Abraham Aseffa, Mario Vaneechoutte

Affiliations

  1. Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
  2. Laboratory Bacteriology Research, Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Belgium.
  3. Department of Microbiology and Immunology, School of Medicine, Addis Ababa University, Ethiopia.
  4. Department of Pediatrics and Child Health, School of Medicine, Addis Ababa University, Ethiopia.
  5. Department of Pediatrics and Child Health, Yekatit 12 Medical College, Addis Ababa, Ethiopia.
  6. Pneumococcal Reference Laboratory, Universitair Ziekenhuis, Katholieke Universiteit Leuven, Belgium.

PMID: 31263735 PMCID: PMC6592415 DOI: 10.1093/ofid/ofz259

Abstract

BACKGROUND: There is a scarcity of data on pneumococcal serotypes carried by children in Ethiopia. We studied pneumococcal nasopharyngeal carriage rate, serotypes, and risk factors among children with community acquired pneumonia (CAP).

METHODS: A prospective observational cohort study was performed in children with CAP, aged 0-15 years, in 2 pediatric emergency departments in Addis Ababa, Ethiopia. Nasopharyngeal swabs were cultured, and serotypes of

RESULTS: Nasopharyngeal swabs were collected from 362 children with CAP. Pneumococcal carriage rate was 21.5% (78 of 362). The most common serotypes were 19A (27%), 16F (8.5%), and 6A (4.9%). In addition, 8.5% of the pneumococcal isolates were nontypeable. In bivariate analysis, children with a parent that smokes were more likely to carry pneumococci (crude odds ratio, 3.9; 95% confidence interval [CI], 1.2-12.3;

CONCLUSIONS: Five years after introduction of PCV10 in Ethiopia, the vaccine-related serotype 19A was predominant in the nasopharynx of children with CAP. Continued evaluation of the direct and indirect impact of PCV10 on pneumococcal serotype distribution in Ethiopia is warranted.

Keywords: community-acquired pneumonia; Ethiopia; PCV10; nasopharyngeal pneumococcal carriage

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