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Ali H, Assiri MA, Shearn CT, et al. Lipid peroxidation derived reactive aldehydes in alcoholic liver disease. Curr Opin Toxicol. 2018;13:110-117doi: 10.1016/j.cotox.2018.10.003.
Ali, H., Assiri, M. A., Shearn, C. T., & Fritz, K. S. (2019). Lipid peroxidation derived reactive aldehydes in alcoholic liver disease. Current opinion in toxicology, 13110-117. https://doi.org/10.1016/j.cotox.2018.10.003
Ali, Hadi, et al. "Lipid peroxidation derived reactive aldehydes in alcoholic liver disease." Current opinion in toxicology vol. 13 (2019): 110-117. doi: https://doi.org/10.1016/j.cotox.2018.10.003
Ali H, Assiri MA, Shearn CT, Fritz KS. Lipid peroxidation derived reactive aldehydes in alcoholic liver disease. Curr Opin Toxicol. 2019 Feb;13:110-117. doi: 10.1016/j.cotox.2018.10.003. Epub 2018 Oct 15. PMID: 31263795; PMCID: PMC6602539.
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Curr Opin Toxicol. 2019 Feb;13:110-117. doi: 10.1016/j.cotox.2018.10.003. Epub 2018 Oct 15.

Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.

Current opinion in toxicology

Hadi Ali, Mohammed A Assiri, Colin T Shearn, Kristofer S Fritz

Affiliations

  1. Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, CO.

PMID: 31263795 PMCID: PMC6602539 DOI: 10.1016/j.cotox.2018.10.003

Abstract

Lipid peroxidation is a known consequence of oxidative stress and is thought to play a key role in numerous disease pathologies, including alcoholic liver disease (ALD). The overaccumulation of lipid peroxidation products during chronic alcohol consumption results in pathogenic lesions on protein, DNA, and lipids throughout the cell. Molecular adducts due to secondary end products of lipid peroxidation impact a host of biochemical processes, including inflammation, antioxidant defense, and metabolism. The aggregate burden of lipid peroxidation which occurs due to chronic alcohol metabolism, including downstream signaling events, contributes to the development and progression of ALD. In this current opinion we highlight recent studies and approaches relating cellular mechanisms of lipid peroxidation to the pathogenesis of alcoholic liver disease.

Conflict of interest statement

Conflict of Interest The authors declare no conflict of interest.

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