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Vemula SR, Kumar D, Cook GR. Bismuth-Catalyzed Synthesis of 2-Substituted Quinazolinones. Tetrahedron Lett. 2018;59(42):3801-3805doi: 10.1016/j.tetlet.2018.09.014.
Vemula, S. R., Kumar, D., & Cook, G. R. (2018). Bismuth-Catalyzed Synthesis of 2-Substituted Quinazolinones. Tetrahedron letters, 59(42), 3801-3805. https://doi.org/10.1016/j.tetlet.2018.09.014
Vemula, Sandeep R, et al. "Bismuth-Catalyzed Synthesis of 2-Substituted Quinazolinones." Tetrahedron letters vol. 59,42 (2018): 3801-3805. doi: https://doi.org/10.1016/j.tetlet.2018.09.014
Vemula SR, Kumar D, Cook GR. Bismuth-Catalyzed Synthesis of 2-Substituted Quinazolinones. Tetrahedron Lett. 2018 Oct 17;59(42):3801-3805. doi: 10.1016/j.tetlet.2018.09.014. Epub 2018 Sep 07. PMID: 31274936; PMCID: PMC6605782.
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Tetrahedron Lett. 2018 Oct 17;59(42):3801-3805. doi: 10.1016/j.tetlet.2018.09.014. Epub 2018 Sep 07.

Bismuth-Catalyzed Synthesis of 2-Substituted Quinazolinones.

Tetrahedron letters

Sandeep R Vemula, Dinesh Kumar, Gregory R Cook

Affiliations

  1. Department of Chemistry and Biochemistry, North Dakota State University, Fargo, ND 58108-6050, USA.
  2. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, Gandhinagar 382355, Gujarat, India.

PMID: 31274936 PMCID: PMC6605782 DOI: 10.1016/j.tetlet.2018.09.014

Abstract

The bismuth-catalyzed oxidative condensation of aldehydes with 2-aminobenzamide under aerobic conditions is reported using ethanol as the solvent. Good to excellent isolated yields (68-95%) of the corresponding 2-substituted quinazolinones were obtained under mild reaction conditions with excellent functional group tolerance. The quinazolinones were further functionalized to afford

Keywords: Bismuth; Catalysis; Condensation; Green chemistry; Quinazolinone

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