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Kumar A, Palek R, Liska V. A Critical Analysis of Experimental Animal Models of Sinusoidal Obstruction Syndrome. J Clin Exp Hepatol. 2018;9(3):345-353doi: 10.1016/j.jceh.2018.07.002.
Kumar, A., Palek, R., & Liska, V. (2019). A Critical Analysis of Experimental Animal Models of Sinusoidal Obstruction Syndrome. Journal of clinical and experimental hepatology, 9(3), 345-353. https://doi.org/10.1016/j.jceh.2018.07.002
Kumar, Arvind, et al. "A Critical Analysis of Experimental Animal Models of Sinusoidal Obstruction Syndrome." Journal of clinical and experimental hepatology vol. 9,3 (2019): 345-353. doi: https://doi.org/10.1016/j.jceh.2018.07.002
Kumar A, Palek R, Liska V. A Critical Analysis of Experimental Animal Models of Sinusoidal Obstruction Syndrome. J Clin Exp Hepatol. 2019 May-Jun;9(3):345-353. doi: 10.1016/j.jceh.2018.07.002. Epub 2018 Jul 17. PMID: 31360027; PMCID: PMC6637067.
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J Clin Exp Hepatol. 2019 May-Jun;9(3):345-353. doi: 10.1016/j.jceh.2018.07.002. Epub 2018 Jul 17.

A Critical Analysis of Experimental Animal Models of Sinusoidal Obstruction Syndrome.

Journal of clinical and experimental hepatology

Arvind Kumar, Richard Palek, Vaclav Liska

Affiliations

  1. Biomedical Center, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czech Republic.
  2. Department of Surgery, Charles University, Faculty of Medicine in Pilsen, Teaching Hospital Pilsen, Pilsen, Czech Republic.

PMID: 31360027 PMCID: PMC6637067 DOI: 10.1016/j.jceh.2018.07.002

Abstract

Given the high mortality rate and clinical impact associated with sinusoidal obstruction syndrome (SOS), many studies have attempted to better characterize the disease and potential treatment strategies. However, the unpredictability of SOS onset represents a major obstacle when developing reproducible and controlled clinical trials in humans. Similarly, although

Keywords: BM SPC, Bone Marrow Endothelial Progenitor Cell; CRLM, Colorectal Liver Metastases; CV, Central Vein; HSCT, Hematopoietic Stem Cell Transplantation; HVOD, Hepatic Veno-Occlusive Disease; MCT, Monocrotaline; MMP-9, Matrix Metalloproteinase-9; NO, Nitric Oxide; PA, Pyrrolizidine Alkaloid; RILD, Radiation-Induced Liver Disease; SEC, Sinusoidal Endothelial Cell; SOS, Sinusoidal Obstruction Syndrome; blue liver disease; in vivo; monocrotaline; oxaliplatin; veno-occlusive disease

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