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Mycielska ME, Mohr MTJ, Schmidt K, et al. Potential Use of Gluconate in Cancer Therapy. Front Oncol. 2019;9:522doi: 10.3389/fonc.2019.00522.
Mycielska, M. E., Mohr, M. T. J., Schmidt, K., Drexler, K., Rümmele, P., Haferkamp, S., Schlitt, H. J., Gaumann, A., Adamski, J., Geissler, E. K., Anand, A., Fosso, S., & Gnanzou, D. (2019). Potential Use of Gluconate in Cancer Therapy. Frontiers in oncology, 9522. https://doi.org/10.3389/fonc.2019.00522
Mycielska, Maria E, et al. "Potential Use of Gluconate in Cancer Therapy." Frontiers in oncology vol. 9 (2019): 522. doi: https://doi.org/10.3389/fonc.2019.00522
Mycielska ME, Mohr MTJ, Schmidt K, Drexler K, Rümmele P, Haferkamp S, Schlitt HJ, Gaumann A, Adamski J, Geissler EK, Anand A, Fosso S, Gnanzou D. Potential Use of Gluconate in Cancer Therapy. Front Oncol. 2019 Jun 19;9:522. doi: 10.3389/fonc.2019.00522. eCollection 2019. PMID: 31275855; PMCID: PMC6593216.
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Front Oncol. 2019 Jun 19;9:522. doi: 10.3389/fonc.2019.00522. eCollection 2019.

Potential Use of Gluconate in Cancer Therapy.

Frontiers in oncology

Maria E Mycielska, Markus T J Mohr, Katharina Schmidt, Konstantin Drexler, Petra Rümmele, Sebastian Haferkamp, Hans J Schlitt, Andreas Gaumann, Jerzy Adamski, Edward K Geissler, Anand, Fosso, Gnanzou

Affiliations

  1. Section of Experimental Surgery, Department of Surgery, University Hospital Regensburg, Regensburg, Germany.
  2. Metempyrosis-Data Analysis in Medicine and Information Technology, Regensburg, Germany.
  3. Department of Dermatology, University Hospital Regensburg, Regensburg, Germany.
  4. Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
  5. Institute of Pathology Kaufbeuren-Ravensburg, Kaufbeuren, Germany.
  6. Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  7. Lehrstuhl Für Experimentelle Genetik, Technische Universität München, Munich, Germany.
  8. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

PMID: 31275855 PMCID: PMC6593216 DOI: 10.3389/fonc.2019.00522

Abstract

We have recently discovered that cancer cells take up extracellular citrate through plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decreased tumor growth and altered metabolic characteristics of tumor tissue. Interestingly, gluconate, considered to be physiologically neutral, is incidentally used in medicine as a cation carrier, but not as a therapeutically active substance. In this review we discuss the results of our recent research with available literature and suggest that gluconate may be useful in the treatment of cancer.

Keywords: cancer metabolism; citrate; gluconate; metabolic targeting; transporter

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