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Brown G, Ceredig R. Modeling the Hematopoietic Landscape. Front Cell Dev Biol. 2019;7:104doi: 10.3389/fcell.2019.00104.
Brown, G., & Ceredig, R. (2019). Modeling the Hematopoietic Landscape. Frontiers in cell and developmental biology, 7104. https://doi.org/10.3389/fcell.2019.00104
Brown, Geoffrey, and Ceredig, Rhodri. "Modeling the Hematopoietic Landscape." Frontiers in cell and developmental biology vol. 7 (2019): 104. doi: https://doi.org/10.3389/fcell.2019.00104
Brown G, Ceredig R. Modeling the Hematopoietic Landscape. Front Cell Dev Biol. 2019 Jun 18;7:104. doi: 10.3389/fcell.2019.00104. eCollection 2019. PMID: 31275935; PMCID: PMC6591273.
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Front Cell Dev Biol. 2019 Jun 18;7:104. doi: 10.3389/fcell.2019.00104. eCollection 2019.

Modeling the Hematopoietic Landscape.

Frontiers in cell and developmental biology

Geoffrey Brown, Rhodri Ceredig

Affiliations

  1. Institute of Clinical Sciences - Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
  2. National University of Ireland Galway, Galway, Ireland.

PMID: 31275935 PMCID: PMC6591273 DOI: 10.3389/fcell.2019.00104

Abstract

Some time ago, we proposed a continuum-like view of the lineages open to hematopoietic stem cells (HSCs); each HSC self-renews or chooses from the spectrum of all end-cell options and can then "merely" differentiate. Having selected a cell lineage, an individual HSC may still "step sideways" to an alternative, albeit closely related, fate: HSC and their progeny therefore remain versatile. The hematopoietic cytokines erythropoietin, granulocyte colony-stimulating factor, macrophage colony-stimulating factor, granulocyte/macrophage colony-stimulating factor and ligand for the fms-like tyrosine kinase 3 instruct cell lineage. Sub-populations of HSCs express each of the cytokine receptors that are positively auto-regulated upon cytokine binding. Many years ago, Waddington proposed that the epigenetic landscape played an important role in cell lineage choice. This landscape is dynamic and unstable especially regarding DNA methylation patterns across genomic DNA. This may underlie the receptor diversity of HSC and their decision-making.

Keywords: blood cells; fate determination; hematopoiesis; hematopoietic stem cells; immune cells

References

  1. Oncogene. 1999 Feb 18;18(7):1495-501 - PubMed
  2. Trends Endocrinol Metab. 1999 Dec;10(1):18-23 - PubMed
  3. Immunity. 1999 Aug;11(2):153-61 - PubMed
  4. Am J Pathol. 1999 Nov;155(5):1557-67 - PubMed
  5. Oncogene. 2000 Feb 3;19(5):624-31 - PubMed
  6. Blood. 2000 May 15;95(10):3025-31 - PubMed
  7. Nature. 2000 Sep 21;407(6802):383-6 - PubMed
  8. Nat Med. 2001 Apr;7(4):444-51 - PubMed
  9. Oncogene. 2001 Sep 20;20(42):6039-47 - PubMed
  10. Blood. 2002 Aug 1;100(3):998-1007 - PubMed
  11. Blood. 2002 Oct 1;100(7):2430-40 - PubMed
  12. Blood. 2003 Apr 15;101(8):3164-73 - PubMed
  13. Eur J Immunol. 2003 Apr;33(4):1063-9 - PubMed
  14. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11823-7 - PubMed
  15. Nat Immunol. 2003 Oct;4(10):1029-36 - PubMed
  16. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):204-9 - PubMed
  17. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):4-5 - PubMed
  18. Blood. 2004 Apr 15;103(8):2950-5 - PubMed
  19. Nat Genet. 2004 Jun;36(6):624-30 - PubMed
  20. Immunity. 2004 Jun;20(6):735-45 - PubMed
  21. Blood. 2005 Mar 1;105(5):1930-6 - PubMed
  22. Nature. 1992 Apr 2;356(6368):397-400 - PubMed
  23. Trends Cell Biol. 2005 Mar;15(3):146-55 - PubMed
  24. Eur J Immunol. 2005 Jul;35(7):2019-30 - PubMed
  25. J Immunol. 2005 Oct 15;175(8):5160-9 - PubMed
  26. Cell. 1992 Jul 10;70(1):31-46 - PubMed
  27. Oncogene. 2006 Apr 20;25(17):2477-88 - PubMed
  28. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1030-5 - PubMed
  29. J Exp Med. 2006 Jan 23;203(1):227-38 - PubMed
  30. J Transl Med. 2006 Feb 16;4:9 - PubMed
  31. Cell. 2006 Apr 21;125(2):315-26 - PubMed
  32. Blood. 1991 Dec 1;78(11):2791-808 - PubMed
  33. Trends Immunol. 2007 Oct;28(10):442-8 - PubMed
  34. Eur J Immunol. 2007 Nov;37 Suppl 1:S34-45 - PubMed
  35. Cell Stem Cell. 2007 Oct 11;1(4):416-27 - PubMed
  36. Cancer Res. 2008 May 1;68(9):3142-51 - PubMed
  37. Cell. 2008 Jun 13;133(6):1106-17 - PubMed
  38. Pathobiology. 1991;59(4):284-8 - PubMed
  39. PLoS One. 2008;3(10):e3405 - PubMed
  40. Nat Rev Immunol. 2009 Apr;9(4):293-300 - PubMed
  41. Cell Signal. 2009 Sep;21(9):1361-9 - PubMed
  42. Science. 2009 Jun 26;324(5935):1679-82 - PubMed
  43. Science. 2009 Jul 10;325(5937):217-8 - PubMed
  44. Clin Cancer Res. 2009 Sep 1;15(17):5303-7 - PubMed
  45. Cell Mol Life Sci. 2010 Jan;67(1):43-62 - PubMed
  46. Cancer Cell. 2009 Nov 6;16(5):390-400 - PubMed
  47. Blood. 1991 Mar 15;77(6):1131-45 - PubMed
  48. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15443-8 - PubMed
  49. Nucleic Acids Res. 2011 May;39(10):4099-108 - PubMed
  50. Stem Cell Res Ther. 2011 Feb 10;2(1):6 - PubMed
  51. Cell Cycle. 2011 May 15;10(10):1582-9 - PubMed
  52. Cancer Res. 2012 Jan 1;72(1):187-200 - PubMed
  53. Blood. 2012 Feb 23;119(8):1810-20 - PubMed
  54. Nat Rev Genet. 2012 Oct;13(10):732-44 - PubMed
  55. Science. 1990 Apr 20;248(4953):378-81 - PubMed
  56. Nature. 2013 May 9;497(7448):239-43 - PubMed
  57. Nature. 2013 Oct 10;502(7470):232-6 - PubMed
  58. Genome Biol. 2013;14(9):R99 - PubMed
  59. Haematologica. 2014 Apr;99(4):638-46 - PubMed
  60. J Exp Med. 2014 Feb 10;211(2):181-8 - PubMed
  61. Leukemia. 2014 Sep;28(9):1851-60 - PubMed
  62. Cold Spring Harb Perspect Biol. 2014 Jun 02;6(6):null - PubMed
  63. Biol Chem. 2014 Nov 1;395(11):1265-74 - PubMed
  64. PLoS One. 2015 Sep 18;10(9):e0138257 - PubMed
  65. Oncotarget. 2015 Dec 22;6(41):43326-41 - PubMed
  66. Science. 2016 Jan 8;351(6269):aab2116 - PubMed
  67. Cell. 2015 Dec 17;163(7):1663-77 - PubMed
  68. J Immunol. 2016 Jul 1;197(1):11-8 - PubMed
  69. Blood. 2016 Aug 25;128(8):e20-31 - PubMed
  70. Nature. 2016 Jul 13;535(7611):299-302 - PubMed
  71. FEBS Lett. 2016 Nov;590(22):3975-3986 - PubMed
  72. Nature. 2016 Sep 29;537(7622):698-702 - PubMed
  73. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8122-E8130 - PubMed
  74. Nat Cell Biol. 2017 Apr;19(4):271-281 - PubMed
  75. Cell Rep. 2017 Apr 11;19(2):295-306 - PubMed
  76. Genome Res. 2017 Jul;27(7):1250-1262 - PubMed
  77. Int J Mol Sci. 2017 May 12;18(5):null - PubMed
  78. Int J Mol Sci. 2017 Jun 09;18(6):null - PubMed
  79. Int J Mol Sci. 2017 Jun 21;18(6):null - PubMed
  80. EMBO J. 2017 Dec 15;36(24):3619-3633 - PubMed
  81. Immunol Cell Biol. 2018 Oct;96(9):898-911 - PubMed
  82. Stem Cell Reports. 2018 Jun 5;10(6):1908-1919 - PubMed
  83. Nat Cell Biol. 2018 Jun;20(6):710-720 - PubMed
  84. Trends Cancer. 2018 Jun;4(6):408-417 - PubMed
  85. EMBO J. 2018 Jul 13;37(14): - PubMed
  86. Leukemia. 2019 Jan;33(1):249-278 - PubMed
  87. Nat Commun. 2018 Jul 12;9(1):2697 - PubMed
  88. Int J Mol Sci. 2018 Jul 21;19(7):null - PubMed
  89. Blood. 2019 Feb 28;133(9):927-939 - PubMed
  90. Blood. 2019 Mar 28;133(13):1427-1435 - PubMed
  91. Rep Biochem Mol Biol. 2019 Jan;7(2):136-141 - PubMed
  92. Leukemia. 2019 Mar 11;:null - PubMed
  93. J Cell Physiol. 1982 Jun;111(3):275-83 - PubMed
  94. Mol Cell Biol. 1994 Mar;14(3):2113-8 - PubMed
  95. Exp Hematol. 1994 Jul;22(7):593-8 - PubMed
  96. Mol Cell Biol. 1995 Oct;15(10):5830-45 - PubMed
  97. Leukemia. 1995 Jul;9(7):1212-8 - PubMed
  98. Blood. 1993 Dec 15;82(12):3515-23 - PubMed
  99. Mol Cell Biol. 1994 Jan;14(1):373-81 - PubMed
  100. Blood. 1996 Aug 15;88(4):1234-47 - PubMed
  101. Br J Haematol. 1997 Mar;96(3):551-8 - PubMed
  102. Genes Dev. 1997 Mar 15;11(6):774-85 - PubMed
  103. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5792-7 - PubMed
  104. Curr Opin Genet Dev. 1997 Oct;7(5):609-13 - PubMed
  105. Cell. 1998 Jul 10;94(1):9-12 - PubMed

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