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Mansoor R, Saeed H, Wali RM, et al. Malnutrition, Sepsis, and Tumor Lysis Syndrome Are Associated with Increased Rate of Acute Mortality in Mature B Cell Non-Hodgkin Lymphoma in a Pediatric Population-Study from Tertiary Care Hospital in Pakistan. Mediterr J Hematol Infect Dis. 2019;11(1):e2019043doi: 10.4084/MJHID.2019.043.
Mansoor, R., Saeed, H., Wali, R. M., Rehman, P., & Abubakar, M. (2019). Malnutrition, Sepsis, and Tumor Lysis Syndrome Are Associated with Increased Rate of Acute Mortality in Mature B Cell Non-Hodgkin Lymphoma in a Pediatric Population-Study from Tertiary Care Hospital in Pakistan. Mediterranean journal of hematology and infectious diseases, 11(1), e2019043. https://doi.org/10.4084/MJHID.2019.043
Mansoor, Raheela, et al. "Malnutrition, Sepsis, and Tumor Lysis Syndrome Are Associated with Increased Rate of Acute Mortality in Mature B Cell Non-Hodgkin Lymphoma in a Pediatric Population-Study from Tertiary Care Hospital in Pakistan." Mediterranean journal of hematology and infectious diseases vol. 11,1 (2019): e2019043. doi: https://doi.org/10.4084/MJHID.2019.043
Mansoor R, Saeed H, Wali RM, Rehman P, Abubakar M. Malnutrition, Sepsis, and Tumor Lysis Syndrome Are Associated with Increased Rate of Acute Mortality in Mature B Cell Non-Hodgkin Lymphoma in a Pediatric Population-Study from Tertiary Care Hospital in Pakistan. Mediterr J Hematol Infect Dis. 2019 Jul 01;11(1):e2019043. doi: 10.4084/MJHID.2019.043. eCollection 2019. PMID: 31308919; PMCID: PMC6613629.
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Mediterr J Hematol Infect Dis. 2019 Jul 01;11(1):e2019043. doi: 10.4084/MJHID.2019.043. eCollection 2019.

Malnutrition, Sepsis, and Tumor Lysis Syndrome Are Associated with Increased Rate of Acute Mortality in Mature B Cell Non-Hodgkin Lymphoma in a Pediatric Population-Study from Tertiary Care Hospital in Pakistan.

Mediterranean journal of hematology and infectious diseases

Raheela Mansoor, Haleema Saeed, Rabia Muhammad Wali, Palwasha Rehman, Muhammad Abubakar

Affiliations

  1. Department of Paediatric Oncology. Shaukat Khanum Memorial Cancer Hospital and Research Centre.
  2. Cancer Registry. Shaukat Khanum Memorial Cancer Hospital and Research Centre.

PMID: 31308919 PMCID: PMC6613629 DOI: 10.4084/MJHID.2019.043

Abstract

BACKGROUND: Outcomes of pediatric mature B cell non-Hodgkin's lymphoma in resource-challenged countries are negatively affected by an increased rate of early and toxic deaths. Aim of this study is to assess the rate of acute mortality and define significant risk factors present in children with mature B cell non-Hodgkin's lymphoma.

METHODS: A retrospective analysis was done of patients with B cell non-Hodgkin's lymphoma from January 2012 till December 2016. Risk factors studied for acute mortality were malnutrition, stage, prior surgery with open laparotomy, lactate dehydrogenase levels, tumor lysis syndrome, sepsis, and fungal infection.

RESULTS: A total of 233 patients were enrolled in the study. Eighty-five (36.4%) were below 15

CONCLUSION: Rate of acute mortality in mature B cell NHL is high in our set up and significant risk factors are tumor lysis syndrome, sepsis, and malnourishment at the time of presentation.

Keywords: Acute mortality; Malnutrition; Mature B cell non-Hodgkin lymphoma; Sepsis; Tumor lysis syndrome

Conflict of interest statement

Competing interests: The authors have declared that no competing interests exist.

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