Display options
Cite
Piedra Abusharar S, Shah N, Patel R, et al. A Case of Confirmed Ceftriaxone-induced Immune Thrombocytopenia. Cureus. 2019;11(5):e4688doi: 10.7759/cureus.4688.
Piedra Abusharar, S., Shah, N., Patel, R., Jain, R., & Polimera, H. V. (2019). A Case of Confirmed Ceftriaxone-induced Immune Thrombocytopenia. Cureus, 11(5), e4688. https://doi.org/10.7759/cureus.4688
Piedra Abusharar, Shady, et al. "A Case of Confirmed Ceftriaxone-induced Immune Thrombocytopenia." Cureus vol. 11,5 (2019): e4688. doi: https://doi.org/10.7759/cureus.4688
Piedra Abusharar S, Shah N, Patel R, Jain R, Polimera HV. A Case of Confirmed Ceftriaxone-induced Immune Thrombocytopenia. Cureus. 2019 May 17;11(5):e4688. doi: 10.7759/cureus.4688. PMID: 31338265; PMCID: PMC6639063.
Copy Download .nbib Format: NLM
Share it on

Cureus. 2019 May 17;11(5):e4688. doi: 10.7759/cureus.4688.

A Case of Confirmed Ceftriaxone-induced Immune Thrombocytopenia.

Cureus

Shady Piedra Abusharar, Neal Shah, Ravi Patel, Rohit Jain, Hyma V Polimera

Affiliations

  1. Internal Medicine, Penn State College of Medicine/ Penn State Health Milton S. Hershey Medical Center, Hershey, USA.
  2. Internal Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.

PMID: 31338265 PMCID: PMC6639063 DOI: 10.7759/cureus.4688

Abstract

Drug-induced immune thrombocytopenia (DITP) is a rare, but potentially fatal cause of isolated thrombocytopenia. DITP is thought to occur when drug-dependent antibodies bind to the platelet membrane glycoproteins to activate platelet consumption signaling. Common implicated drugs include quinine/quinidine, penicillamines, valproic acid and cotrimoxazole. Ceftriaxone is a rare culprit with only six reported cases since 1991, of which only three were confirmed with drug-dependent antiplatelet antibodies. We describe a case of antibody confirmed ceftriaxone-induced immune thrombocytopenia after initiation of empiric antibiotic therapy for acute bacterial meningitis.

Keywords: ceftriaxone; drug induced thrombocytopenia; immune thrombocytopenia; meningitis; thrombocytopenia

Conflict of interest statement

The authors have declared that no competing interests exist.

References

  1. Pediatr Infect Dis J. 2002 Jan;21(1):14-22 - PubMed
  2. Transfusion. 2004 Jul;44(7):1033-40 - PubMed
  3. Clin Infect Dis. 2004 Nov 1;39(9):1267-84 - PubMed
  4. Drug Saf. 2004;27(15):1243-52 - PubMed
  5. J Thromb Haemost. 2009 Jun;7(6):911-8 - PubMed
  6. Hematology Am Soc Hematol Educ Program. 2009;:153-8 - PubMed
  7. Transfusion. 2013 Nov;53(11):2715-21 - PubMed
  8. J Community Hosp Intern Med Perspect. 2017 Jul 13;7(3):157-167 - PubMed
  9. Eur J Clin Pharmacol. 1997;52(3):183-9 - PubMed
  10. Ann Intern Med. 1998 Dec 1;129(11):886-90 - PubMed

Publication Types