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Caruso G, Fresta CG, Fidilio A, et al. Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages. Antioxidants (Basel). 2019;8(8)doi: 10.3390/antiox8080281.
Caruso, G., Fresta, C. G., Fidilio, A., O'Donnell, F., Musso, N., Lazzarino, G., Grasso, M., Amorini, A. M., Tascedda, F., Bucolo, C., Drago, F., Tavazzi, B., Lazzarino, G., Lunte, S. M., & Caraci, F. (2019). Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages. Antioxidants (Basel, Switzerland), 8(8), . https://doi.org/10.3390/antiox8080281
Caruso, Giuseppe, et al. "Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages." Antioxidants (Basel, Switzerland) vol. 8,8 (2019). doi: https://doi.org/10.3390/antiox8080281
Caruso G, Fresta CG, Fidilio A, O'Donnell F, Musso N, Lazzarino G, Grasso M, Amorini AM, Tascedda F, Bucolo C, Drago F, Tavazzi B, Lazzarino G, Lunte SM, Caraci F. Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages. Antioxidants (Basel). 2019 Aug 06;8(8). doi: 10.3390/antiox8080281. PMID: 31390749; PMCID: PMC6720685.
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Antioxidants (Basel). 2019 Aug 06;8(8). doi: 10.3390/antiox8080281.

Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages.

Antioxidants (Basel, Switzerland)

Giuseppe Caruso, Claudia G Fresta, Annamaria Fidilio, Fergal O'Donnell, Nicolò Musso, Giacomo Lazzarino, Margherita Grasso, Angela M Amorini, Fabio Tascedda, Claudio Bucolo, Filippo Drago, Barbara Tavazzi, Giuseppe Lazzarino, Susan M Lunte, Filippo Caraci

Affiliations

  1. Department of Laboratories, Oasi Research Institute-IRCCS, 94018 Troina, Italy. [email protected].
  2. Ralph N. Adams Institute for Bioanalytical Chemistry, University of Kansas, Lawrence, KS 66047-1620, USA.
  3. Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047-1620, USA.
  4. Department of Drug Sciences, University of Catania, 95125 Catania, Italy.
  5. School of Biotechnology, Dublin City University, D09W6Y4 Dublin, Ireland.
  6. Bio-Nanotech Research and Innovation Tower (BRIT), University of Catania, 95125 Catania, Italy.
  7. Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, 00168 Rome, Italy.
  8. Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
  9. Department of Laboratories, Oasi Research Institute-IRCCS, 94018 Troina, Italy.
  10. Department of Biomedical and Biotechnological Sciences, University of Catania, 95125 Catania, Italy.
  11. Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
  12. Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy.
  13. Department of Biomedical and Biotechnological Sciences, University of Catania, 95125 Catania, Italy. [email protected].
  14. Department of Chemistry, University of Kansas, Lawrence, KS 66047-1620, USA.

PMID: 31390749 PMCID: PMC6720685 DOI: 10.3390/antiox8080281

Abstract

Carnosine is an endogenous dipeptide composed of β-alanine and L-histidine. This naturally occurring molecule is present at high concentrations in several mammalian excitable tissues such as muscles and brain, while it can be found at low concentrations in a few invertebrates. Carnosine has been shown to be involved in different cellular defense mechanisms including the inhibition of protein cross-linking, reactive oxygen and nitrogen species detoxification as well as the counteraction of inflammation. As a part of the immune response, macrophages are the primary cell type that is activated. These cells play a crucial role in many diseases associated with oxidative stress and inflammation, including atherosclerosis, diabetes, and neurodegenerative diseases. In the present study, carnosine was first tested for its ability to counteract oxidative stress. In our experimental model, represented by RAW 264.7 macrophages challenged with phorbol 12-myristate 13-acetate (PMA) and superoxide dismutase (SOD) inhibitors, carnosine was able to decrease the intracellular concentration of superoxide anions (O

Keywords: antioxidants; carnosine; inflammation; macrophages; oxidative stress; superoxide

References

  1. Circulation. 1999 Jul 20;100(3):216-8 - PubMed
  2. Biochim Biophys Acta. 1999 Nov 16;1472(3):651-7 - PubMed
  3. Age Ageing. 2000 May;29(3):207-10 - PubMed
  4. Biochim Biophys Acta. 2000 Oct 20;1498(1):19-31 - PubMed
  5. Biochem Biophys Res Commun. 2000 Nov 11;278(1):1-8 - PubMed
  6. Circulation. 2002 Mar 26;105(12):1429-35 - PubMed
  7. Ann N Y Acad Sci. 2002 May;962:207-11 - PubMed
  8. Cardiovasc Res. 2002 Aug 1;55(2):239-49 - PubMed
  9. Biochim Biophys Acta. 1959 Jan;31(1):47-55 - PubMed
  10. Nature. 1992 Oct 22;359(6397):693-9 - PubMed
  11. J Biol Chem. 1959 Dec;234:3210-8 - PubMed
  12. Biokhimiia. 1992 Sep;57(9):1352-9 - PubMed
  13. Anal Biochem. 2003 Nov 1;322(1):51-9 - PubMed
  14. J Neuroinflammation. 2005 Sep 12;2:20 - PubMed
  15. Curr Med Chem. 2005;12(20):2293-315 - PubMed
  16. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15038-43 - PubMed
  17. J Immunol. 2006 Nov 1;177(9):6317-24 - PubMed
  18. Mol Biotechnol. 2007 Sep;37(1):2-4 - PubMed
  19. Annu Rev Immunol. 2009;27:451-83 - PubMed
  20. ACS Chem Biol. 2009 Mar 20;4(3):161-77 - PubMed
  21. Biosci Rep. 2010 Mar 12;30(4):233-41 - PubMed
  22. Diabetes. 2009 Nov;58(11):2574-82 - PubMed
  23. J Biol Chem. 2010 Mar 26;285(13):9346-56 - PubMed
  24. Pharmacol Rep. 2010 Jul-Aug;62(4):733-9 - PubMed
  25. J Agric Food Chem. 2010 Nov 10;58(21):11510-6 - PubMed
  26. Mol Microbiol. 2011 May;80(3):580-3 - PubMed
  27. Hum Exp Toxicol. 2011 Dec;30(12):1979-85 - PubMed
  28. Antioxid Redox Signal. 2011 Sep 15;15(6):1583-606 - PubMed
  29. Eur J Pharmacol. 2011 Sep 30;667(1-3):202-7 - PubMed
  30. Exp Diabetes Res. 2012;2012:703538 - PubMed
  31. ScientificWorldJournal. 2011;11:2391-402 - PubMed
  32. Immunol Res. 2012 Sep;53(1-3):11-24 - PubMed
  33. J Alzheimers Dis. 2013;33(4):983-97 - PubMed
  34. World Allergy Organ J. 2012 Jan;5(1):9-19 - PubMed
  35. Chem Cent J. 2013 Feb 25;7(1):38 - PubMed
  36. Anal Chem. 2013 Nov 5;85(21):10188-95 - PubMed
  37. Physiol Rev. 2013 Oct;93(4):1803-45 - PubMed
  38. Biomed Res Int. 2013;2013:484613 - PubMed
  39. Pharmacol Rep. 2013;65(6):1663-72 - PubMed
  40. Analyst. 2014 Jul 7;139(13):3265-73 - PubMed
  41. J Cancer. 2014 Apr 24;5(5):382-9 - PubMed
  42. Arch Gerontol Geriatr. 2014 Sep-Oct;59(2):485-90 - PubMed
  43. Regul Pept. 2014 Jun-Aug;192-193:45-52 - PubMed
  44. Immunology. 2015 Jun;145(2):213-24 - PubMed
  45. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):560-5 - PubMed
  46. PLoS One. 2015 Feb 06;10(2):e0116549 - PubMed
  47. J Clin Biochem Nutr. 2015 Jan;56(1):1-7 - PubMed
  48. Biomolecules. 2015 Apr 15;5(2):472-84 - PubMed
  49. Sci Rep. 2015 Jun 10;5:11252 - PubMed
  50. Anal Bioanal Chem. 2015 Sep;407(23):7003-12 - PubMed
  51. Redox Biol. 2015 Aug;5:398-408 - PubMed
  52. Cell Physiol Biochem. 2015;37(2):816-24 - PubMed
  53. Mol Neurobiol. 2016 Oct;53(8):5582-90 - PubMed
  54. Biol Rev Camb Philos Soc. 2017 Feb;92(1):369-377 - PubMed
  55. Front Aging Neurosci. 2015 Nov 27;7:219 - PubMed
  56. Eur J Pharmacol. 2016 Sep 15;787:72-7 - PubMed
  57. Brain Res Bull. 2016 Jun;124:76-84 - PubMed
  58. Neuroscience. 2016 Aug 25;330:326-34 - PubMed
  59. J Biochem Mol Toxicol. 2017 Jul;31(7):null - PubMed
  60. Sci Rep. 2017 Mar 10;7:44492 - PubMed
  61. Front Immunol. 2017 Feb 27;8:200 - PubMed
  62. Mol Cell Biochem. 2017 Jul;431(1-2):197-210 - PubMed
  63. Int J Mol Sci. 2017 Apr 17;18(4):null - PubMed
  64. Neuropharmacology. 2017 Jul 15;121:30-38 - PubMed
  65. Anal Bioanal Chem. 2017 Jul;409(19):4529-4538 - PubMed
  66. J Food Drug Anal. 2017 Jan;25(1):111-118 - PubMed
  67. Int J Mol Sci. 2017 Sep 30;18(10):null - PubMed
  68. Nutrients. 2017 Oct 31;9(11):null - PubMed
  69. Anal Methods. 2017 Jan 21;9(3):402-408 - PubMed
  70. Pharmacol Res. 2018 Apr;130:374-384 - PubMed
  71. Cell Death Dis. 2018 Feb 14;9(2):245 - PubMed
  72. Biochem Pharmacol. 1986 May 15;35(10):1762-4 - PubMed
  73. Mol Genet Metab. 2018 Nov;125(3):305-313 - PubMed
  74. Int Immunol. 2018 Oct 29;30(11):511-528 - PubMed
  75. Hum Reprod. 2018 Oct 1;33(10):1817-1828 - PubMed
  76. Pharmaceuticals (Basel). 2018 Oct 21;11(4):null - PubMed
  77. Immunol Lett. 2018 Sep;201:38-44 - PubMed
  78. Acta Pharmacol Sin. 2019 Jul;40(7):938-948 - PubMed
  79. Prog Neurobiol. 2019 Apr;175:35-53 - PubMed
  80. Curr Pharm Biotechnol. 2018;19(15):1196-1202 - PubMed
  81. Cells. 2019 Jan 17;8(1): - PubMed
  82. Mitochondrion. 2019 Jul;47:266-272 - PubMed
  83. Antioxidants (Basel). 2019 Apr 11;8(4):null - PubMed
  84. Comp Biochem Physiol. 1970 Dec 1;37(3):413-9 - PubMed
  85. Biochem Mol Biol Int. 1997 Sep;43(1):99-106 - PubMed
  86. Res Immunol. 1997 Sep;148(7):453-6 - PubMed
  87. Ann N Y Acad Sci. 1998 Nov 20;854:37-53 - PubMed

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