Display options
Cite
Dedloff MR, Effler CS, Holban AM, et al. Use of Biopolymers in Mucosally-Administered Vaccinations for Respiratory Disease. Materials (Basel). 2019;12(15)doi: 10.3390/ma12152445.
Dedloff, M. R., Effler, C. S., Holban, A. M., & Gestal, M. C. (2019). Use of Biopolymers in Mucosally-Administered Vaccinations for Respiratory Disease. Materials (Basel, Switzerland), 12(15), . https://doi.org/10.3390/ma12152445
Dedloff, Margaret R, et al. "Use of Biopolymers in Mucosally-Administered Vaccinations for Respiratory Disease." Materials (Basel, Switzerland) vol. 12,15 (2019). doi: https://doi.org/10.3390/ma12152445
Dedloff MR, Effler CS, Holban AM, Gestal MC. Use of Biopolymers in Mucosally-Administered Vaccinations for Respiratory Disease. Materials (Basel). 2019 Jul 31;12(15). doi: 10.3390/ma12152445. PMID: 31370286; PMCID: PMC6695719.
Copy Download .nbib Format: NLM
Share it on

Materials (Basel). 2019 Jul 31;12(15). doi: 10.3390/ma12152445.

Use of Biopolymers in Mucosally-Administered Vaccinations for Respiratory Disease.

Materials (Basel, Switzerland)

Margaret R Dedloff, Callie S Effler, Alina Maria Holban, Monica C Gestal

Affiliations

  1. Department of Biology, Clarkson University, Potsdam, NY 13699, USA.
  2. Department of Natural Sciences and Mathematics, College of Arts and Sciences, Lee University, Cleveland, TN 37311, USA.
  3. Department of Microbiology, Faculty of Biology, University of Bucharest, 030018 Bucuresti, Romania.
  4. Research Institute of the University of Bucharest (ICUB), 050107 Bucharest, Romania.
  5. Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania.
  6. Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA. [email protected].

PMID: 31370286 PMCID: PMC6695719 DOI: 10.3390/ma12152445

Abstract

Communicable respiratory infections are the cause of a significant number of infectious diseases. The introduction of vaccinations has greatly improved this situation. Moreover, adjuvants have allowed for vaccines to be more effective with fewer adverse side effects. However, there is still space for improvement because while the more common injected formulations induce a systematic immunity, they do not confer the mucosal immunity needed for more thorough prevention of the spread of respiratory disease. Intranasal formulations provide systemic and mucosal immune protection, but they have the potential for more serious side effects and a less robust immune response. This review looks at seven different adjuvants-chitosan, starch, alginate, gellan, β-glucan, emulsan and hyaluronic acid-and their prospective ability to improve intranasal vaccines as adjuvants and antigen delivery systems.

Keywords: immunomodulation; mucosal administration; nanovaccines; polymeric vaccines; respiratory infections

References

  1. Pharm Res. 1999 Mar;16(3):382-90 - PubMed
  2. Infect Immun. 2000 Jul;68(7):3873-7 - PubMed
  3. Infect Immun. 2000 Oct;68(10):5764-70 - PubMed
  4. Vaccine. 2000 Dec 8;19(9-10):1188-98 - PubMed
  5. J Control Release. 2001 Feb 23;70(3):267-76 - PubMed
  6. Adv Drug Deliv Rev. 2001 Sep 23;51(1-3):81-96 - PubMed
  7. Vet Immunol Immunopathol. 2001 Nov;83(1-2):93-105 - PubMed
  8. J Exp Med. 2002 Aug 5;196(3):407-12 - PubMed
  9. Pharm Res. 2002 Jul;19(7):998-1008 - PubMed
  10. Vaccine. 2002 Sep 10;20(27-28):3355-63 - PubMed
  11. Drug Discov Today. 2002 Sep 15;7(18):967-75 - PubMed
  12. Immunity. 2003 Sep;19(3):311-5 - PubMed
  13. Eur J Pharm Biopharm. 2004 Jan;57(1):123-31 - PubMed
  14. J Drug Target. 2004 Jun;12(5):289-96 - PubMed
  15. Oncol Rep. 2005 Mar;13(3):497-502 - PubMed
  16. Eur J Pharm Biopharm. 2005 Apr;59(3):557-64 - PubMed
  17. Pediatr Infect Dis J. 2005 May;24(5 Suppl):S58-61 - PubMed
  18. Nat Rev Microbiol. 2006 Jun;4(6):469-76 - PubMed
  19. Bioessays. 2006 Aug;28(8):799-808 - PubMed
  20. Vaccine. 2007 Jan 2;25(1):144-53 - PubMed
  21. Mol Pharm. 2007 Jan-Feb;4(1):33-46 - PubMed
  22. Eur J Pharm Sci. 2007 Dec;32(4-5):278-90 - PubMed
  23. Eur J Pharm Biopharm. 2008 Jun;69(2):405-16 - PubMed
  24. Infect Immun. 2009 May;77(5):1774-81 - PubMed
  25. J Immunother (1991). 1991 Aug;10(4):286-91 - PubMed
  26. Influenza Other Respir Viruses. 2009 Jan;3(1):37-49 - PubMed
  27. Nanomedicine. 2010 Feb;6(1):137-43 - PubMed
  28. J Biol Chem. 2009 Oct 9;284(41):28263-75 - PubMed
  29. J Mol Genet Med. 2009 Dec 09;3(2):198-204 - PubMed
  30. MBio. 2010 Jul 20;1(3):null - PubMed
  31. J Control Release. 2011 Nov 30;156(1):46-52 - PubMed
  32. Prog Polym Sci. 2012 Jan;37(1):106-126 - PubMed
  33. Eur J Pharm Biopharm. 2012 Aug;81(3):463-9 - PubMed
  34. Clin Dev Immunol. 2013;2013:387023 - PubMed
  35. Clin Vaccine Immunol. 2013 Oct;20(10):1585-91 - PubMed
  36. J Control Release. 2013 Dec 28;172(3):671-8 - PubMed
  37. Int J Pharm. 2014 Mar 25;463(2):137-45 - PubMed
  38. Indian J Pharm Sci. 2013 Jul;75(4):442-9 - PubMed
  39. Int J Pharm. 2014 May 15;466(1-2):328-40 - PubMed
  40. Int J Biol Macromol. 2014 Jun;67:490-502 - PubMed
  41. Ther Adv Vaccines. 2013 May;1(1):21-31 - PubMed
  42. Int J Pharm. 2014 Oct 20;474(1-2):241-8 - PubMed
  43. Curr Pharm Biotechnol. 2015;16(2):128-36 - PubMed
  44. ACS Macro Lett. 2014 Jul 15;3(7):652-657 - PubMed
  45. Int J Pharm. 2015 Jul 5;488(1-2):12-9 - PubMed
  46. J Control Release. 2015 Jun 28;208:121-129 - PubMed
  47. Molecules. 2016 Jul 01;21(7): - PubMed
  48. Lancet. 2016 Oct 8;388(10053):1459-1544 - PubMed
  49. J Immunol Res. 2016;2016:5482087 - PubMed
  50. Hum Vaccin Immunother. 2017 Jun 3;13(6):1-9 - PubMed
  51. Vaccine. 1987 Dec;5(4):270-4 - PubMed
  52. Lancet Infect Dis. 2017 Sep;17(9):974-980 - PubMed
  53. Artif Cells Nanomed Biotechnol. 2018 May;46(3):452-464 - PubMed
  54. Molecules. 2018 Jan 25;23(2):null - PubMed
  55. Biomed Res Int. 2018 Jun 11;2018:7670505 - PubMed
  56. Int J Mol Sci. 2018 Nov 19;19(11):null - PubMed
  57. Polymers (Basel). 2018 Jan 02;10(1):null - PubMed
  58. J Pharm Sci. 1986 Oct;75(10):962-7 - PubMed
  59. Vaccine. 1985 Dec;3(5):379-84 - PubMed
  60. Am J Infect Control. 1984 Dec;12(6):329-34 - PubMed
  61. J Pharm Sci. 1980 Dec;69(12):1411-3 - PubMed
  62. Vaccine. 1995 May;13(7):629-36 - PubMed
  63. Carbohydr Res. 1993 Apr 23;243(1):211-6 - PubMed
  64. Infect Immun. 1993 Feb;61(2):399-410 - PubMed
  65. Can J Microbiol. 1997 Apr;43(4):384-90 - PubMed
  66. Vaccine. 1998 Dec;16(20):2039-46 - PubMed

Publication Types