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Choudhury S. Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis. Bioinformation. 2019;15(6):430-438doi: 10.6026/97320630015430.
Choudhury, S. (2019). Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis. Bioinformation, 15(6), 430-438. https://doi.org/10.6026/97320630015430
Choudhury, Shouhartha. "Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis." Bioinformation vol. 15,6 (2019): 430-438. doi: https://doi.org/10.6026/97320630015430
Choudhury S. Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis. Bioinformation. 2019 Jun 15;15(6):430-438. doi: 10.6026/97320630015430. eCollection 2019. PMID: 31312081; PMCID: PMC6614118.
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Bioinformation. 2019 Jun 15;15(6):430-438. doi: 10.6026/97320630015430. eCollection 2019.

Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis.

Bioinformation

Shouhartha Choudhury

Affiliations

  1. Department of Biotechnology, Assam University, Silchar 788011, Assam, India.

PMID: 31312081 PMCID: PMC6614118 DOI: 10.6026/97320630015430

Abstract

The glial cell neoplasms are not fully classified by using cellular morphology. However, this is possible using known molecular markers in glial development. Oligo-dendrocyte lineage gene induces differentiation of neural progenitors and putative immature progenitor cells of the adult central nervous system. These oligo-dendrocyte lineage genes OLIG1 and OLIG2 encode basic helix-loop-helix transcription factors. The murine bHLH transcription factors found in chromosome 21 are essential for oligo-dendrocyte development. Moreover, OLIG3 of the OLIG family is known to be linked with the brain and spinal cord development. Therefore, it is of interest to analyse oligodendrocyte lineage genes in the OLIG family of bHLH domain for the understanding of oligo-dendrogenesis in eukaryotes. Several bHLH domain linked basic-helix-loop-helix transcription factors in Homo sapiens and Mus musculus from this analysis are reported. Thus, genomics data analysis of OLIG family of bHLH transcription factors help explain observed similarity and differences within the molecular evolutionary context and hence assess the functional significance of the distinct genetic blueprints.

Keywords: OLIG family; bHLH transcription factor; oligo dendrogenesis

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