Display options
Cite
Hellberg M, Höglund P, Svensson P, et al. Randomized Controlled Trial of Exercise in CKD-The RENEXC Study. Kidney Int Rep. 2019;4(7):963-976doi: 10.1016/j.ekir.2019.04.001.
Hellberg, M., Höglund, P., Svensson, P., & Clyne, N. (2019). Randomized Controlled Trial of Exercise in CKD-The RENEXC Study. Kidney international reports, 4(7), 963-976. https://doi.org/10.1016/j.ekir.2019.04.001
Hellberg, Matthias, et al. "Randomized Controlled Trial of Exercise in CKD-The RENEXC Study." Kidney international reports vol. 4,7 (2019): 963-976. doi: https://doi.org/10.1016/j.ekir.2019.04.001
Hellberg M, Höglund P, Svensson P, Clyne N. Randomized Controlled Trial of Exercise in CKD-The RENEXC Study. Kidney Int Rep. 2019 Apr 09;4(7):963-976. doi: 10.1016/j.ekir.2019.04.001. eCollection 2019 Jul. PMID: 31312771; PMCID: PMC6609793.
Copy Download .nbib Format: NLM
Share it on

Kidney Int Rep. 2019 Apr 09;4(7):963-976. doi: 10.1016/j.ekir.2019.04.001. eCollection 2019 Jul.

Randomized Controlled Trial of Exercise in CKD-The RENEXC Study.

Kidney international reports

Matthias Hellberg, Peter Höglund, Philippa Svensson, Naomi Clyne

Affiliations

  1. Department of Nephrology, Institution of Clinical Sciences Lund, Lund, Sweden.
  2. Faculty of Medicine, Lund University, Lund, Sweden.
  3. Faculty of Medicine, Skåne University Hospital, Lund Sweden.
  4. Department of Clinical Chemistry and Pharmacology, Institution of Laboratory Medicine Lund, Lund, Sweden.

PMID: 31312771 PMCID: PMC6609793 DOI: 10.1016/j.ekir.2019.04.001

Abstract

INTRODUCTION: Home-based, clinically feasible trials in non-dialysis-dependent patients with chronic kidney disease (CKD) are sparse. We compared the effects of 2 different exercise training programs on physical performance, and measured glomerular filtration rate (mGFR) and albuminuria level in patients with CKD stages 3 to 5.

METHODS: This is a single-center, randomized controlled trial (RCT) comprising 151 patients (mGFR: 22 ± 8 ml/min per 1.73 m

RESULTS: There were no treatment differences for any of the primary outcomes measuring physical performance. The strength and balance groups showed significantly increased effect sizes after 12 months for the following: walking (31 m and 24 m,

CONCLUSION: Our primary hypothesis that strength training was superior to balance training was not confirmed. Within groups, 12 months of exercise training resulted in significant improvements in most measures of physical performance. Measured GFR declined similarly in the 2 groups. The strength group showed a significant decrease in albuminuria.

Keywords: albuminuria; chronic kidney disease; exercise training; glomerular filtration rate; physical performance; randomized controlled trial

References

  1. J Am Soc Nephrol. 1999 Jun;10(6):1204-13 - PubMed
  2. Kidney Int. 2000 Jun;57(6):2564-70 - PubMed
  3. Nephron. 2001 May;88(1):48-56 - PubMed
  4. J Rehabil Med. 2002 Jan;34(1):40-5 - PubMed
  5. Nephrol Dial Transplant. 2002 Jun;17(6):1085-92 - PubMed
  6. Int J Rehabil Res. 2003 Jun;26(2):153-6 - PubMed
  7. Am J Kidney Dis. 2004 Apr;43(4):607-16 - PubMed
  8. J Am Soc Nephrol. 2006 Aug;17(8):2307-14 - PubMed
  9. Clin J Am Soc Nephrol. 2006 Nov;1(6):1197-204 - PubMed
  10. Nephrol Dial Transplant. 2008 Sep;23(9):2827-33 - PubMed
  11. Clin Chem. 2009 Jan;55(1):24-38 - PubMed
  12. J Am Soc Nephrol. 2009 Nov;20(11):2427-32 - PubMed
  13. Arch Intern Med. 2009 Dec 14;169(22):2116-23 - PubMed
  14. Scand J Clin Lab Invest. 2010 Apr;70(2):65-70 - PubMed
  15. Int Urol Nephrol. 2011 Dec;43(4):1133-41 - PubMed
  16. Med Sci Sports Exerc. 2011 Aug;43(8):1457-64 - PubMed
  17. Kidney Int. 2011 Jun;79(12):1331-40 - PubMed
  18. Kidney Int. 2011 Jun;79(12):1341-52 - PubMed
  19. Cochrane Database Syst Rev. 2011 Oct 05;(10):CD003236 - PubMed
  20. Nephrol Dial Transplant. 2012 Oct;27 Suppl 3:iii126-34 - PubMed
  21. Med Sci Sports Exerc. 2012 Dec;44(12):2392-9 - PubMed
  22. J Am Soc Nephrol. 2013 Apr;24(5):822-30 - PubMed
  23. Nephron. 1990;55(3):306-11 - PubMed
  24. Clin J Am Soc Nephrol. 2013 Sep;8(9):1494-501 - PubMed
  25. J Am Soc Nephrol. 2014 Feb;25(2):399-406 - PubMed
  26. J Am Soc Nephrol. 2014 Sep;25(9):2121-30 - PubMed
  27. Nephron Clin Pract. 2014;126(3):116-23 - PubMed
  28. BMC Public Health. 2014 May 27;14:510 - PubMed
  29. Am J Kidney Dis. 2014 Sep;64(3):383-93 - PubMed
  30. BMC Nephrol. 2014 Jul 08;15:108 - PubMed
  31. Nephrol Dial Transplant. 2014 Oct;29(10):1947-55 - PubMed
  32. Am J Kidney Dis. 2015 Mar;65(3):425-34 - PubMed
  33. Am J Kidney Dis. 2015 Apr;65(4):583-91 - PubMed
  34. Am J Kidney Dis. 2015 Mar;65(3):412-24 - PubMed
  35. Am J Kidney Dis. 2015 Aug;66(2):249-57 - PubMed
  36. Clin J Am Soc Nephrol. 2015 Jun 5;10(6):1079-88 - PubMed
  37. BMJ Open. 2015 Aug 27;5(8):e008709 - PubMed
  38. Am J Physiol Heart Circ Physiol. 2015 Dec 1;309(11):H1876-82 - PubMed
  39. Nat Rev Nephrol. 2015 Nov;11(11):667-76 - PubMed
  40. Clin Kidney J. 2015 Dec;8(6):753-65 - PubMed
  41. Diabetologia. 1989 Apr;32(4):219-26 - PubMed
  42. Nephrology (Carlton). 2017 Jul;22(7):513-519 - PubMed
  43. JRSM Cardiovasc Dis. 2016 Nov 03;5:2048004016677687 - PubMed
  44. J Am Soc Nephrol. 2017 Apr;28(4):1259-1268 - PubMed
  45. Kidney Int. 2017 Jan;91(1):244-251 - PubMed
  46. Nephrol Dial Transplant. 2018 Feb 1;33(2):342-348 - PubMed
  47. Clin J Am Soc Nephrol. 2017 Dec 7;12(12):1941-1949 - PubMed
  48. Kidney Int. 1987 Dec;32(6):815-20 - PubMed
  49. Med Sci Sports Exerc. 1982;14(5):377-81 - PubMed
  50. J Am Soc Nephrol. 1995 Aug;6(2):257-63 - PubMed
  51. Kidney Int. 1996 Jun;49(6):1774-7 - PubMed
  52. Nephron. 1997;75(1):36-40 - PubMed
  53. Kidney Int. 1998 May;53(5):1209-16 - PubMed
  54. Kidney Int. 1998 Jun;53(6):1608-15 - PubMed
  55. Nephrol Dial Transplant. 1998;13 Suppl 7:41-7 - PubMed

Publication Types