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Milani M, Beckett AJ, Al-Zebeeby A, et al. DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis. Cell Death Discov. 2019;5:117doi: 10.1038/s41420-019-0199-x.
Milani, M., Beckett, A. J., Al-Zebeeby, A., Luo, X., Prior, I. A., Cohen, G. M., & Varadarajan, S. (2019). DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis. Cell death discovery, 5117. https://doi.org/10.1038/s41420-019-0199-x
Milani, Mateus, et al. "DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis." Cell death discovery vol. 5 (2019): 117. doi: https://doi.org/10.1038/s41420-019-0199-x
Milani M, Beckett AJ, Al-Zebeeby A, Luo X, Prior IA, Cohen GM, Varadarajan S. DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis. Cell Death Discov. 2019 Jul 17;5:117. doi: 10.1038/s41420-019-0199-x. eCollection 2019. PMID: 31341643; PMCID: PMC6637195.
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Cell Death Discov. 2019 Jul 17;5:117. doi: 10.1038/s41420-019-0199-x. eCollection 2019.

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis.

Cell death discovery

Mateus Milani, Alison J Beckett, Aoula Al-Zebeeby, Xu Luo, Ian A Prior, Gerald M Cohen, Shankar Varadarajan

Affiliations

  1. 1Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, Ashton Street, Liverpool, L69 3GE UK.
  2. 2Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, Ashton Street, Liverpool, L69 3GE UK.
  3. 3Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198 USA.
  4. 4Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, Ashton Street, Liverpool, L69 3GE UK.

PMID: 31341643 PMCID: PMC6637195 DOI: 10.1038/s41420-019-0199-x

Abstract

Maintenance of mitochondrial integrity is critical for normal cellular homoeostasis. Most cells respond to stress stimuli and undergo apoptosis by perturbing mitochondrial structure and function to release proteins, such as cytochrome

Keywords: Cell death; Organelles

Conflict of interest statement

Conflict of interestThe authors declare that they have no conflict of interest.

References

  1. Dev Cell. 2002 Jan;2(1):55-67 - PubMed
  2. Cell. 2004 Jan 23;116(2):205-19 - PubMed
  3. Mol Cell. 2005 Feb 4;17(3):393-403 - PubMed
  4. Nature. 2005 Jun 2;435(7042):677-81 - PubMed
  5. Cancer Cell. 2006 Nov;10(5):389-99 - PubMed
  6. Oncogene. 2007 Feb 26;26(9):1324-37 - PubMed
  7. Annu Rev Biochem. 2007;76:751-80 - PubMed
  8. Nat Rev Mol Cell Biol. 2008 Jan;9(1):47-59 - PubMed
  9. Cell Death Differ. 2008 May;15(5):820-30 - PubMed
  10. Cancer Res. 2008 May 1;68(9):3421-8 - PubMed
  11. Mol Cell. 2008 Aug 22;31(4):557-69 - PubMed
  12. Blood. 2009 Apr 30;113(18):4403-13 - PubMed
  13. Nat Rev Drug Discov. 2008 Dec;7(12):989-1000 - PubMed
  14. Science. 2011 Oct 21;334(6054):358-62 - PubMed
  15. J Cell Biol. 2011 Oct 17;195(2):263-76 - PubMed
  16. Nat Cell Biol. 2012 Apr 29;14(6):575-83 - PubMed
  17. Trends Cell Biol. 2012 Jun;22(6):318-28 - PubMed
  18. Nat Med. 2013 Feb;19(2):202-8 - PubMed
  19. Neoplasia. 2013 May;15(5):568-78 - PubMed
  20. Nat Cell Biol. 2013 Jul;15(7):773-85 - PubMed
  21. Br J Haematol. 2013 Oct;163(1):139-42 - PubMed
  22. Cancer Cell. 2013 Jul 8;24(1):120-9 - PubMed
  23. Cell Death Dis. 2015 Jan 15;6:e1590 - PubMed
  24. Sci Transl Med. 2015 Mar 18;7(279):279ra40 - PubMed
  25. Oncotarget. 2015 May 20;6(14):12668-81 - PubMed
  26. Oncotarget. 2015 Sep 8;6(26):22598-612 - PubMed
  27. Oncotarget. 2015 Oct 6;6(30):30017-34 - PubMed
  28. Mol Cell. 2015 Sep 17;59(6):941-55 - PubMed
  29. Neurobiol Dis. 2016 Jun;90:3-19 - PubMed
  30. Mol Biol Cell. 2016 Jan 1;27(1):20-34 - PubMed
  31. N Engl J Med. 2016 Jan 28;374(4):311-22 - PubMed
  32. Heart Fail Rev. 2016 Mar;21(2):123-36 - PubMed
  33. J Cell Biol. 2016 Feb 29;212(5):531-44 - PubMed
  34. Leukemia. 2016 Jun;30(6):1273-81 - PubMed
  35. Genes Dev. 2016 Apr 15;30(8):973-88 - PubMed
  36. Nature. 2016 Oct 27;538(7626):477-482 - PubMed
  37. Nature. 2016 Dec 1;540(7631):139-143 - PubMed
  38. Cell Death Dis. 2017 Jan 12;8(1):e2552 - PubMed
  39. Nat Commun. 2017 Jun 09;8:15754 - PubMed
  40. Oncotarget. 2018 Apr 13;9(28):20075-20088 - PubMed
  41. Biol Chem. 2019 Jan 28;400(2):181-185 - PubMed
  42. Cell Death Differ. 2019 Jun;26(6):1037-1047 - PubMed
  43. Cancer Discov. 2018 Dec;8(12):1582-1597 - PubMed
  44. Haematologica. 2019 May;104(5):1016-1025 - PubMed
  45. Nat Commun. 2018 Dec 17;9(1):5341 - PubMed

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