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Beijer E, Meek B, Kromhout H, et al. Sarcoidosis in a patient clinically diagnosed with silicosis; is silica associated sarcoidosis a new phenotype?. Respir Med Case Rep. 2019;28:100906doi: 10.1016/j.rmcr.2019.100906.
Beijer, E., Meek, B., Kromhout, H., van Es, H. W., Seldenrijk, K., Drent, M., Rooijackers, J. M., & Veltkamp, M. (2019). Sarcoidosis in a patient clinically diagnosed with silicosis; is silica associated sarcoidosis a new phenotype?. Respiratory medicine case reports, 28100906. https://doi.org/10.1016/j.rmcr.2019.100906
Beijer, Els, et al. "Sarcoidosis in a patient clinically diagnosed with silicosis; is silica associated sarcoidosis a new phenotype?." Respiratory medicine case reports vol. 28 (2019): 100906. doi: https://doi.org/10.1016/j.rmcr.2019.100906
Beijer E, Meek B, Kromhout H, van Es HW, Seldenrijk K, Drent M, Rooijackers JM, Veltkamp M. Sarcoidosis in a patient clinically diagnosed with silicosis; is silica associated sarcoidosis a new phenotype?. Respir Med Case Rep. 2019 Jul 10;28:100906. doi: 10.1016/j.rmcr.2019.100906. eCollection 2019. PMID: 31341766; PMCID: PMC6630015.
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Respir Med Case Rep. 2019 Jul 10;28:100906. doi: 10.1016/j.rmcr.2019.100906. eCollection 2019.

Sarcoidosis in a patient clinically diagnosed with silicosis; is silica associated sarcoidosis a new phenotype?.

Respiratory medicine case reports

Els Beijer, Bob Meek, Hans Kromhout, H Wouter van Es, Kees Seldenrijk, Marjolein Drent, Jos M Rooijackers, Marcel Veltkamp

Affiliations

  1. Interstitial Lung Diseases Center of Excellence, Department of Pulmonology, St. Antonius Hospital, Nieuwegein, the Netherlands.
  2. Department of Medical Microbiology and Immunology, St. Antonius Hospital, Nieuwegein, the Netherlands.
  3. Institute for Risk Assessment Sciences, Utrecht University, the Netherlands.
  4. Department of Radiology, St. Antonius Hospital, Nieuwegein, the Netherlands.
  5. Pathology DNA, Department of Pathology, St. Antonius Hospital, Nieuwegein, the Netherlands.
  6. Department of Pharmacology and Toxicology, FHML, Maastricht University, Maastricht, the Netherlands.
  7. Netherlands Expertise Center for Occupational Respiratory Disorders, Utrecht, the Netherlands.
  8. Department of Pulmonology, University Medical Center, Utrecht, the Netherlands.

PMID: 31341766 PMCID: PMC6630015 DOI: 10.1016/j.rmcr.2019.100906

Abstract

A diagnosis of silicosis is made on the basis of exposure and typical radiological findings, according to the ILO's International Classification of Radiographs of Pneumoconiosis. Radiological patterns of silicosis can, however, resemble sarcoidosis. Sarcoidosis is a multi-systemic disorder of unknown etiology, although a role for initiating inorganic triggers such as metals or silica has been suggested. In this case report, we illustrate a patient previously diagnosed with silicosis based on exposure and radiological features, progressive under immunosuppressive treatment. In view of these findings, an open lung biopsy was performed and revealed sarcoidosis. The patient was effectively treated with infliximab. Further analysis showed the presence of silica in the granulomas. Sensitization to silica was also demonstrated, suggesting an association between silica exposure and sarcoidosis in this patient.

Keywords: 18 F-FDG PET/CT, 18F-fluorodeoxyglucose by positron emission tomography/computed tomography; CBD, Chronic beryllium disease; DLCO, diffusing capacity of the lung for carbon monoxide; EDXA, Energy-dispersive X-ray spectroscopy analysis; FVC, Forced Vital Capacity; HRCT, High-resolution computed tomography; Infliximab; LPT, Lymphocyte proliferation test; Sarcoidosis; Sarcoidosis phenotypes; Silica; Silicosis

References

  1. Lancet. 2009 Jun 6;373(9679):1943-4 - PubMed
  2. Am J Respir Crit Care Med. 2006 Oct 1;174(7):795-802 - PubMed
  3. Eur Respir J. 2006 Jun;27(6):1190-5 - PubMed
  4. Med Pr. 2016 Dec 22;67(6):833-837 - PubMed
  5. Occup Environ Med. 1998 Oct;55(10):657-60 - PubMed
  6. BMJ Open. 2017 Jul 20;7(7):e016839 - PubMed
  7. Dis Mon. 2007 Aug;53(8):394-416 - PubMed
  8. Zhonghua Jie He He Hu Xi Za Zhi. 2008 Jun;31(6):406-9 - PubMed
  9. Acta Biomed. 2005;76 Suppl 2:11-4 - PubMed
  10. Sarcoidosis Vasc Diffuse Lung Dis. 2003 Jun;20(2):104-9 - PubMed
  11. Eur Respir J. 1998 Sep;12(3):750 - PubMed
  12. Respir Med. 2018 May;138S:S7-S13 - PubMed
  13. Toxicol In Vitro. 1994 Oct;8(5):991-1000 - PubMed
  14. Am J Respir Crit Care Med. 2014 Nov 15;190(10):e34-59 - PubMed
  15. Eur Respir J. 2012 Jan;39(1):221-2 - PubMed
  16. Eur Respir J. 2015 Jul;46(1):175-85 - PubMed
  17. Respir Med. 2012 Dec;106(12):1810-3 - PubMed

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