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Siwele BA, Makhado NA, Mariba MT. Late diagnosis of multidrug-resistant tuberculosis in a child at Dr George Mukhari Academic Hospital, Ga-Rankuwa, South Africa: A case report. Afr J Lab Med. 2019;8(1):783doi: 10.4102/ajlm.v8i1.783.
Siwele, B. A., Makhado, N. A., & Mariba, M. T. (2019). Late diagnosis of multidrug-resistant tuberculosis in a child at Dr George Mukhari Academic Hospital, Ga-Rankuwa, South Africa: A case report. African journal of laboratory medicine, 8(1), 783. https://doi.org/10.4102/ajlm.v8i1.783
Siwele, Bakani A, et al. "Late diagnosis of multidrug-resistant tuberculosis in a child at Dr George Mukhari Academic Hospital, Ga-Rankuwa, South Africa: A case report." African journal of laboratory medicine vol. 8,1 (2019): 783. doi: https://doi.org/10.4102/ajlm.v8i1.783
Siwele BA, Makhado NA, Mariba MT. Late diagnosis of multidrug-resistant tuberculosis in a child at Dr George Mukhari Academic Hospital, Ga-Rankuwa, South Africa: A case report. Afr J Lab Med. 2019 Jul 29;8(1):783. doi: 10.4102/ajlm.v8i1.783. eCollection 2019. PMID: 31392167; PMCID: PMC6676783.
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Afr J Lab Med. 2019 Jul 29;8(1):783. doi: 10.4102/ajlm.v8i1.783. eCollection 2019.

Late diagnosis of multidrug-resistant tuberculosis in a child at Dr George Mukhari Academic Hospital, Ga-Rankuwa, South Africa: A case report.

African journal of laboratory medicine

Bakani A Siwele, Ndivhuho A Makhado, Matodzi T Mariba

Affiliations

  1. Department of Orthopaedics, Sefako Makgatho Health Science University, Pretoria, South Africa.
  2. National Health Laboratory Service - Dr George Mukhari Tertiary Laboratory, Department of Medical Microbiology, Pretoria, South Africa.
  3. Department of Microbiological Pathology, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
  4. Global Health Institute, University of Antwerp, Wilrijk, Belgium.
  5. Department of Biomedical Sciences, Mycobacteriology Unit, Institute of Tropical Medicine, Antwerp, Belgium.

PMID: 31392167 PMCID: PMC6676783 DOI: 10.4102/ajlm.v8i1.783

Abstract

INTRODUCTION: South Africa has one of the top ten tuberculosis burdens in the world, only lagging behind countries with significantly larger populations. Increased awareness of extrapulmonary tuberculosis, specifically spinal tuberculosis, is necessary, because of the HIV epidemic.

CASE PRESENTATION: This report describes the case of a 9-year-old male patient who was suspected of having multidrug-resistant (MDR) tuberculosis, based on failure to recover clinically and radiologically after 6 months on first-line anti-tuberculosis treatment. Pus samples were sent to an accredited academic laboratory for histopathology, microscopy, culture, line-probe assay (MTBDR

MANAGEMENT AND OUTCOME: After laboratory diagnosis of MDR tuberculosis, the patient was started on MDR tuberculosis treatment. The patient started improving remarkably after the introduction of anti-tuberculosis treatment and rehabilitation, although he also required surgery to stabilise the spine. Neurological improvement was observed in the patient and he fully recovered.

DISCUSSION: Although the diagnosis of spinal MDR tuberculosis may not be achieved easily by culture, the well-known gold standard method of tuberculosis diagnosis, it is of great importance to rapidly initiate an effective anti-tuberculosis treatment of drug-resistant strains to reduce the deformity of the spine.

Keywords: extrapulmonary tuberculosis; laboratory diagnosis; multidrug-resistant tuberculosis; radiological improvement; spinal tuberculosis

Conflict of interest statement

The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article.

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