Display options
Cite
Bazoukis G, Naka KK, Alsheikh-Ali A, et al. Association of QRS narrowing with response to cardiac resynchronization therapy-a systematic review and meta-analysis of observational studies. Heart Fail Rev. 2020;25(5):745-756doi: 10.1007/s10741-019-09839-5.
Bazoukis, G., Naka, K. K., Alsheikh-Ali, A., Tse, G., Letsas, K. P., Korantzopoulos, P., Liu, T., Yeung, C., Efremidis, M., Tsioufis, K., Baranchuk, A., & Stavrakis, S. (2020). Association of QRS narrowing with response to cardiac resynchronization therapy-a systematic review and meta-analysis of observational studies. Heart failure reviews, 25(5), 745-756. https://doi.org/10.1007/s10741-019-09839-5
Bazoukis, George, et al. "Association of QRS narrowing with response to cardiac resynchronization therapy-a systematic review and meta-analysis of observational studies." Heart failure reviews vol. 25,5 (2020): 745-756. doi: https://doi.org/10.1007/s10741-019-09839-5
Bazoukis G, Naka KK, Alsheikh-Ali A, Tse G, Letsas KP, Korantzopoulos P, Liu T, Yeung C, Efremidis M, Tsioufis K, Baranchuk A, Stavrakis S. Association of QRS narrowing with response to cardiac resynchronization therapy-a systematic review and meta-analysis of observational studies. Heart Fail Rev. 2020 Sep;25(5):745-756. doi: 10.1007/s10741-019-09839-5. PMID: 31392534.
Copy Download .nbib Format: NLM
Share it on

Heart Fail Rev. 2020 Sep;25(5):745-756. doi: 10.1007/s10741-019-09839-5.

Association of QRS narrowing with response to cardiac resynchronization therapy-a systematic review and meta-analysis of observational studies.

Heart failure reviews

George Bazoukis, Katerina K Naka, Alawi Alsheikh-Ali, Gary Tse, Konstantinos P Letsas, Panagiotis Korantzopoulos, Tong Liu, Cynthia Yeung, Michael Efremidis, Konstantinos Tsioufis, Adrian Baranchuk, Stavros Stavrakis

Affiliations

  1. Second Department of Cardiology, Evangelismos General Hospital of Athens, Athens, Greece. [email protected].
  2. The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. [email protected].
  3. Second Department of Cardiology, University of Ioannina, GR 45110, Ioannina, Greece.
  4. College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
  5. Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China.
  6. Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, People's Republic of China.
  7. Second Department of Cardiology, Evangelismos General Hospital of Athens, Athens, Greece.
  8. First Department of Cardiology, University of Ioannina, GR 45110, Ioannina, Greece.
  9. Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
  10. Division of Cardiology, Queen's University, Kingston, Ontario, Canada.
  11. First Cardiology Clinic, Medical School, Hippokration Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  12. The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

PMID: 31392534 DOI: 10.1007/s10741-019-09839-5

Abstract

Prolonged QRS duration, which reflects a higher degree of mechanical dysynchrony, is a predictor of response to CRT. However, the association of QRS narrowing after biventricular pacing with CRT response rates is not clear. Our aim was to conduct a systematic review and meta-analysis on the association between QRS narrowing after cardiac resynchronization therapy (CRT) and clinical and echocardiographic response to CRT in patients with heart failure. Two independent investigators searched MedLine and EMBASE databases through July 2018 without any limitations. Studies providing estimates (continuous data) on the association of QRS shortening with either clinical (defined as New York Heart Association (NYHA) reduction ≥ 1) or echocardiographic (defined as left ventricular end-systolic volume (LVESV) reduction ≥ 15%) response to CRT were finally included in the quantitative synthesis. We included 32 studies (14 studies (1274 patients mean age 64 years old, males 79.3%) using clinical CRT response and 18 studies (1270 patients, mean age 64 years old, males 69.1%) using echocardiographic CRT response). A significant association between QRS narrowing and shorter attained QRS duration with clinical and echocardiographic CRT response was observed. The observed association was independent of the timing of QRS width measurement after CRT implantation. Acute and late improvement of electrical dysynchrony as depicted by QRS narrowing following biventricular pacing is associated with clinical and echocardiographic response to CRT. However, large prospective studies are needed to further examine our findings.

Keywords: CRT response; Cardiac resynchronization therapy; Electrical dysynchrony; QRS narrowing

MeSH terms

Publication Types