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Baishya P, Das J, Shangpliang D, et al. Pediatric Granular Cell Tumor of the Breast: An uncommon neoplasm in an uncommon site and age group. Autops Case Rep. 2019;9(3):e2019099doi: 10.4322/acr.2019.099.
Baishya, P., Das, J., Shangpliang, D., Dey, B., Marbaniang, E., Lynser, D., Khonglah, Y., & Raphael, V. (2019). Pediatric Granular Cell Tumor of the Breast: An uncommon neoplasm in an uncommon site and age group. Autopsy & case reports, 9(3), e2019099. https://doi.org/10.4322/acr.2019.099
Baishya, Pakesh, et al. "Pediatric Granular Cell Tumor of the Breast: An uncommon neoplasm in an uncommon site and age group." Autopsy & case reports vol. 9,3 (2019): e2019099. doi: https://doi.org/10.4322/acr.2019.099
Baishya P, Das J, Shangpliang D, Dey B, Marbaniang E, Lynser D, Khonglah Y, Raphael V. Pediatric Granular Cell Tumor of the Breast: An uncommon neoplasm in an uncommon site and age group. Autops Case Rep. 2019 Jul 12;9(3):e2019099. doi: 10.4322/acr.2019.099. eCollection 2019. PMID: 31372359; PMCID: PMC6629270.
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Autops Case Rep. 2019 Jul 12;9(3):e2019099. doi: 10.4322/acr.2019.099. eCollection 2019.

Pediatric Granular Cell Tumor of the Breast: An uncommon neoplasm in an uncommon site and age group.

Autopsy & case reports

Pakesh Baishya, Jonali Das, Darilin Shangpliang, Biswajit Dey, Evarisalin Marbaniang, Donboklang Lynser, Yookarin Khonglah, Vandana Raphael

Affiliations

  1. North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Department of Pathology. Mawdiangdiang, Shillong, India.
  2. North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Department of Radiodiagnosis. Mawdiangdiang, Shillong, India.

PMID: 31372359 PMCID: PMC6629270 DOI: 10.4322/acr.2019.099

Abstract

Granular cell tumor (GCT) is a rare soft tissue neoplasm of Schwann cell origin. Most cases occur in adults; however, the precise incidence is unknown in children. GCT is usually a slow-growing, painless tumor involving the skin and soft tissues that is mostly located in the head and neck region, especially the tongue. The breast is one of the least common sites involved by GCT. This paper presents a 3-year-old girl who presented with a soft to firm, ill-defined swelling on the right breast with painful ulceration of the overlying skin. Fine needle aspiration rendered an initial diagnosis of fibrocystic change accompanied by apocrine metaplasia. Histologic evaluation of the excised breast mass revealed a benign granular cell tumor. Although rare, GCT of the breast should be included in the differential diagnosis for breast masses in pediatric patients. Proper diagnosis and timely management of this tumor are essential because of its malignant potential (<2% of cases) and high rate of local recurrence if not properly excised.

Keywords: Breast; S100 Proteins; Schwann Cells

Conflict of interest statement

Conflict of interest: None

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