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Aliwaini S, Awadallah AM, Morjan RY, et al. Novel imidazo[1,2-a]pyridine inhibits AKT/mTOR pathway and induces cell cycle arrest and apoptosis in melanoma and cervical cancer cells. Oncol Lett. 2019;18(1):830-837doi: 10.3892/ol.2019.10341.
Aliwaini, S., Awadallah, A. M., Morjan, R. Y., Ghunaim, M., Alqaddi, H., Abuhamad, A. Y., Awadallah, E. A., & Abughefra, Y. M. (2019). Novel imidazo[1,2-a]pyridine inhibits AKT/mTOR pathway and induces cell cycle arrest and apoptosis in melanoma and cervical cancer cells. Oncology letters, 18(1), 830-837. https://doi.org/10.3892/ol.2019.10341
Aliwaini, Saeb, et al. "Novel imidazo[1,2-a]pyridine inhibits AKT/mTOR pathway and induces cell cycle arrest and apoptosis in melanoma and cervical cancer cells." Oncology letters vol. 18,1 (2019): 830-837. doi: https://doi.org/10.3892/ol.2019.10341
Aliwaini S, Awadallah AM, Morjan RY, Ghunaim M, Alqaddi H, Abuhamad AY, Awadallah EA, Abughefra YM. Novel imidazo[1,2-a]pyridine inhibits AKT/mTOR pathway and induces cell cycle arrest and apoptosis in melanoma and cervical cancer cells. Oncol Lett. 2019 Jul;18(1):830-837. doi: 10.3892/ol.2019.10341. Epub 2019 May 13. PMID: 31289560; PMCID: PMC6540349.
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Oncol Lett. 2019 Jul;18(1):830-837. doi: 10.3892/ol.2019.10341. Epub 2019 May 13.

Novel imidazo[1,2-a]pyridine inhibits AKT/mTOR pathway and induces cell cycle arrest and apoptosis in melanoma and cervical cancer cells.

Oncology letters

Saeb Aliwaini, Adel M Awadallah, Rami Y Morjan, Mariam Ghunaim, Hala Alqaddi, Asmaa Y Abuhamad, Enas A Awadallah, Yasmin M Abughefra

Affiliations

  1. Department of Biology and Biotechnology, Islamic University of Gaza, 108 Gaza, Palestine.
  2. Department of Chemistry, Islamic University of Gaza, 108 Gaza, Palestine.

PMID: 31289560 PMCID: PMC6540349 DOI: 10.3892/ol.2019.10341

Abstract

The present study aimed to investigate the anti-cancer activity of imidazo[1,2-a]pyridine 5-7 in the A375 and WM115 melanoma and HeLa cervical cancer cell lines. The viability of cancer cells was analyzed by the MTT assay. Apoptosis was quantified by flow cytometry following staining of the cells with AnnexinV/propidium iodide (PI). The cell cycle was evaluated by flow cytometry after staining of cells with PI. The three compounds inhibited the proliferation of all cells for half maximal inhibitory concentration ranging from 9.7 to 44.6 µM following 48-h treatment. In addition, all cancer cells were more sensitive to compound 6 compared with the other compounds. Treatment with compound 6 induced G

Keywords: apoptosis; cervical cancer; imidazo[1,2-a]pyridine; melanoma; p53

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