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de Oliveira Ferreira R, de Brito Silva R, Magno MB, et al. Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis. Ther Adv Musculoskelet Dis. 2019;11:1759720X19858514doi: 10.1177/1759720X19858514.
de Oliveira Ferreira, R., de Brito Silva, R., Magno, M. B., Carvalho Almeida, A. P. C. P. S., Fagundes, N. C. F., Maia, L. C., & Lima, R. R. (2019). Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis. Therapeutic advances in musculoskeletal disease, 111759720X19858514. https://doi.org/10.1177/1759720X19858514
de Oliveira Ferreira, Railson, et al. "Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis." Therapeutic advances in musculoskeletal disease vol. 11 (2019): 1759720X19858514. doi: https://doi.org/10.1177/1759720X19858514
de Oliveira Ferreira R, de Brito Silva R, Magno MB, Carvalho Almeida APCPS, Fagundes NCF, Maia LC, Lima RR. Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis. Ther Adv Musculoskelet Dis. 2019 Jul 09;11:1759720X19858514. doi: 10.1177/1759720X19858514. eCollection 2019. PMID: 31316593; PMCID: PMC6620730.
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Ther Adv Musculoskelet Dis. 2019 Jul 09;11:1759720X19858514. doi: 10.1177/1759720X19858514. eCollection 2019.

Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis.

Therapeutic advances in musculoskeletal disease

Railson de Oliveira Ferreira, Raíra de Brito Silva, Marcela Baraúna Magno, Anna Paula Costa Ponte Sousa Carvalho Almeida, Nathália Carolina Fernandes Fagundes, Lucianne Cople Maia, Rafael Rodrigues Lima

Affiliations

  1. Laboratory of Functional and Structural Biology, Universidade Federal do Pará, Belém, Brazil.
  2. Department of Pediatric Dentistry and Orthodontics, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  3. Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Rua Augusto Corrêa 1, Guamá, Belém, PA 66075-900, Brazil.

PMID: 31316593 PMCID: PMC6620730 DOI: 10.1177/1759720X19858514

Abstract

Periodontitis is an inflammatory disease of dental supporting tissues (gingiva, periodontal ligament, and bone) and it has been suggested as a possible etiology for rheumatoid arthritis (RA). In this systematic review, we aim to verify if periodontitis represents a risk factor for RA. Electronic databases were consulted until March 2018 considering eligibility criteria focusing on: (P, participants) adults; (E, exposure) with periodontitis; (C, comparison) without periodontitis; and (O, outcome) development of RA. Quality assessment of studies and risk-of-bias evaluation were also performed. To undertake a quantitative analysis, the number of persons with RA and a total number of participants for the case group (with periodontitis) and control group (without periodontitis) were used to calculate the odds ratio (OR) with a 95% confidence interval (CI). A total of 3888 articles were identified, and nine studies were considered eligible. Seven of 9 articles suggested an association among diseases by the common pro-inflammatory profiles. The pooled analysis of 3 articles showed a higher RA prevalence for persons with periodontitis (

Keywords: periodontitis; rheumatoid arthritis; systematic review

Conflict of interest statement

Conflict of interest statement: The authors declare that there is no conflict of interest.

References

  1. Stud Health Technol Inform. 1999;68:323-8 - PubMed
  2. Ann Periodontol. 1999 Dec;4(1):1-6 - PubMed
  3. J Clin Periodontol. 2002 Aug;29(8):672-8 - PubMed
  4. J Dent Res. 1956 Jun;35(3):350-9 - PubMed
  5. Periodontol 2000. 2004;34:9-21 - PubMed
  6. J Periodontol. 2005 Aug;76(8):1406-19 - PubMed
  7. J Clin Periodontol. 2005;32 Suppl 6:210-3 - PubMed
  8. J Soc Integr Oncol. 2006 Fall;4(4):194-8 - PubMed
  9. J Clin Immunol. 1991 May;11(3):132-42 - PubMed
  10. Arthritis Res Ther. 2009;11(3):229 - PubMed
  11. PLoS Med. 2009 Jul 21;6(7):e1000097 - PubMed
  12. BMJ. 1991 May 11;302(6785):1136-40 - PubMed
  13. J Rheumatol. 2010 Sep;37(9):1800-4 - PubMed
  14. J Clin Periodontol. 2010 Dec;37(12):1068-74 - PubMed
  15. Anaerobe. 2011 Aug;17(4):196-200 - PubMed
  16. J Clin Periodontol. 2011 Nov;38(11):998-1006 - PubMed
  17. J Periodontol. 2012 Jul;83(7):917-25 - PubMed
  18. J Periodontol. 2013 Jan;84(1):84-93 - PubMed
  19. J Clin Periodontol. 2012 Jun;39(6):526-36 - PubMed
  20. Arthritis Rheum. 2012 Nov;64(11):3522-30 - PubMed
  21. Ann Rheum Dis. 2013 Jul;72(7):1206-11 - PubMed
  22. Curr Opin Rheumatol. 2013 Mar;25(2):241-7 - PubMed
  23. Ann Rheum Dis. 2014 Mar;73(3):580-6 - PubMed
  24. J Dent Res. 2013 May;92(5):399-408 - PubMed
  25. J Clin Pediatr Dent. 2012 Winter;37(2):117-24 - PubMed
  26. J Clin Periodontol. 2013 Jun;40(6):591-8 - PubMed
  27. Ann Rheum Dis. 2014 Jan;73(1):62-8 - PubMed
  28. Periodontol 2000. 2015 Feb;67(1):13-33 - PubMed
  29. J Autoimmun. 2015 May;59:85-90 - PubMed
  30. PLoS One. 2015 Apr 07;10(4):e0122121 - PubMed
  31. J Periodontol. 2015 Jul;86(7):835-8 - PubMed
  32. PLoS One. 2015 Oct 01;10(10):e0139693 - PubMed
  33. BMC Musculoskelet Disord. 2015 Oct 15;16:300 - PubMed
  34. Br Dent J. 2016 Nov 18;221(10):667-673 - PubMed
  35. Sci Transl Med. 2016 Dec 14;8(369):369ra176 - PubMed
  36. BMC Res Notes. 2017 Jan 7;10(1):34 - PubMed
  37. Acta Odontol Scand. 2017 May;75(4):243-248 - PubMed
  38. Rev Bras Reumatol Engl Ed. 2017 May - Jun;57(3):270-273 - PubMed
  39. Periodontol 2000. 2017 Oct;75(1):52-115 - PubMed
  40. Nat Rev Rheumatol. 2017 Oct;13(10):606-620 - PubMed
  41. Curr Vasc Pharmacol. 2018;16(6):569-582 - PubMed
  42. PLoS One. 2017 Oct 12;12(10):e0186346 - PubMed
  43. Rheumatology (Oxford). 2017 Oct 4;:null - PubMed
  44. J Periodontol. 1992 Apr;63 Suppl 4S:373-382 - PubMed
  45. J Periodontol. 1982 Sep;53(9):568-77 - PubMed

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