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Facchin F, Canaider S, Tassinari R, et al. Physical energies to the rescue of damaged tissues. World J Stem Cells. 2019;11(6):297-321doi: 10.4252/wjsc.v11.i6.297.
Facchin, F., Canaider, S., Tassinari, R., Zannini, C., Bianconi, E., Taglioli, V., Olivi, E., Cavallini, C., Tausel, M., & Ventura, C. (2019). Physical energies to the rescue of damaged tissues. World journal of stem cells, 11(6), 297-321. https://doi.org/10.4252/wjsc.v11.i6.297
Facchin, Federica, et al. "Physical energies to the rescue of damaged tissues." World journal of stem cells vol. 11,6 (2019): 297-321. doi: https://doi.org/10.4252/wjsc.v11.i6.297
Facchin F, Canaider S, Tassinari R, Zannini C, Bianconi E, Taglioli V, Olivi E, Cavallini C, Tausel M, Ventura C. Physical energies to the rescue of damaged tissues. World J Stem Cells. 2019 Jun 26;11(6):297-321. doi: 10.4252/wjsc.v11.i6.297. PMID: 31293714; PMCID: PMC6600852.
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World J Stem Cells. 2019 Jun 26;11(6):297-321. doi: 10.4252/wjsc.v11.i6.297.

Physical energies to the rescue of damaged tissues.

World journal of stem cells

Federica Facchin, Silvia Canaider, Riccardo Tassinari, Chiara Zannini, Eva Bianconi, Valentina Taglioli, Elena Olivi, Claudia Cavallini, Marco Tausel, Carlo Ventura

Affiliations

  1. Department of Experimental, Diagnostic and Specialty Medicine (DIMES), School of Medicine, University of Bologna, Bologna 40100, Italy.
  2. National Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, CNR, Bologna 40100, Italy.
  3. iB3 SA, Lugano 6900, Switzerland.

PMID: 31293714 PMCID: PMC6600852 DOI: 10.4252/wjsc.v11.i6.297

Abstract

Rhythmic oscillatory patterns sustain cellular dynamics, driving the concerted action of regulatory molecules, microtubules, and molecular motors. We describe cellular microtubules as oscillators capable of synchronization and swarming, generating mechanical and electric patterns that impact biomolecular recognition. We consider the biological relevance of seeing the inside of cells populated by a network of molecules that behave as bioelectronic circuits and chromophores. We discuss the novel perspectives disclosed by mechanobiology, bioelectromagnetism, and photobiomodulation, both in term of fundamental basic science and in light of the biomedical implication of using physical energies to govern (stem) cell fate. We focus on the feasibility of exploiting atomic force microscopy and hyperspectral imaging to detect signatures of nanomotions and electromagnetic radiation (light), respectively, generated by the stem cells across the specification of their multilineage repertoire. The chance is reported of using these signatures and the diffusive features of physical waves to direct specifically the differentiation program of stem cells

Keywords: Damaged tissues; Electric fields; Electromagnetic fields; Electromagnetic radiation; Mechanical forces; Photobiomodulation; Physical energies; Stem cells

Conflict of interest statement

Conflict-of-interest statement: No potential conflicts of interest.

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