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Cardinali DP. Melatonin: Clinical Perspectives in Neurodegeneration. Front Endocrinol (Lausanne). 2019;10:480doi: 10.3389/fendo.2019.00480.
Cardinali, D. P. (2019). Melatonin: Clinical Perspectives in Neurodegeneration. Frontiers in endocrinology, 10480. https://doi.org/10.3389/fendo.2019.00480
Cardinali, Daniel P. "Melatonin: Clinical Perspectives in Neurodegeneration." Frontiers in endocrinology vol. 10 (2019): 480. doi: https://doi.org/10.3389/fendo.2019.00480
Cardinali DP. Melatonin: Clinical Perspectives in Neurodegeneration. Front Endocrinol (Lausanne). 2019 Jul 16;10:480. doi: 10.3389/fendo.2019.00480. eCollection 2019. PMID: 31379746; PMCID: PMC6646522.
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Front Endocrinol (Lausanne). 2019 Jul 16;10:480. doi: 10.3389/fendo.2019.00480. eCollection 2019.

Melatonin: Clinical Perspectives in Neurodegeneration.

Frontiers in endocrinology

Daniel P Cardinali

Affiliations

  1. Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Aires, Argentina.

PMID: 31379746 PMCID: PMC6646522 DOI: 10.3389/fendo.2019.00480

Abstract

Prevention of neurodegenerative diseases is presently a major goal for our Society and melatonin, an unusual phylogenetically conserved molecule present in all aerobic organisms, merits consideration in this respect. Melatonin combines both chronobiotic and cytoprotective properties. As a chronobiotic, melatonin can modify phase and amplitude of biological rhythms. As a cytoprotective molecule, melatonin reverses the low degree inflammatory damage seen in neurodegenerative disorders and aging. Low levels of melatonin in blood characterizes advancing age. In experimental models of Alzheimer's disease (AD) and Parkinson's disease (PD) the neurodegeneration observed is prevented by melatonin. Melatonin also increased removal of toxic proteins by the brain glymphatic system. A limited number of clinical trials endorse melatonin's potentiality in AD and PD, particularly at an early stage of disease. Calculations derived from animal studies indicate cytoprotective melatonin doses in the 40-100 mg/day range. Hence, controlled studies employing melatonin doses in this range are urgently needed. The off-label use of melatonin is discussed.

Keywords: Alzheimer's disease; Parkinson's disease; aging; glymphatic system; melatonin; mild cognitive impairment; neurodegeneration; oxidative stress

References

  1. Ann Neurol. 1999 Mar;45(3):358-68 - PubMed
  2. J Pineal Res. 1999 Apr;26(3):137-46 - PubMed
  3. Mov Disord. 1999 May;14(3):507-11 - PubMed
  4. Physiol Behav. 1999 Jul;66(5):785-95 - PubMed
  5. Chronobiol Int. 2000 May;17(3):419-32 - PubMed
  6. Cell Motil Cytoskeleton. 2000 May;46(1):28-42 - PubMed
  7. Arch Gerontol Geriatr. 2000 Aug 1;31(1):65-76 - PubMed
  8. FASEB J. 2001 Jan;15(1):164-170 - PubMed
  9. Psychiatry Clin Neurosci. 2001 Jun;55(3):267-9 - PubMed
  10. Neuro Endocrinol Lett. 2000;21(1):39-42 - PubMed
  11. J Clin Endocrinol Metab. 2001 Oct;86(10):4727-30 - PubMed
  12. Biochemistry. 2001 Dec 11;40(49):14995-5001 - PubMed
  13. Cell Signal. 2002 Mar;14(3):249-57 - PubMed
  14. Life Sci. 2002 Jan 18;70(9):1041-51 - PubMed
  15. Acta Pharmacol Sin. 2002 Feb;23(2):183-7 - PubMed
  16. J Pineal Res. 2002 May;32(4):262-9 - PubMed
  17. Neuro Endocrinol Lett. 2002 Apr;23 Suppl 1:20-3 - PubMed
  18. J Pineal Res. 2002 Apr;32(3):163-7 - PubMed
  19. J Pineal Res. 2002 Oct;33(3):186-7 - PubMed
  20. Int J Geriatr Psychiatry. 2002 Dec;17(12):1120-7 - PubMed
  21. Cell Mol Neurobiol. 2002 Dec;22(5-6):699-709 - PubMed
  22. Neurobiol Aging. 2003 May-Jun;24(3):491-500 - PubMed
  23. J Pineal Res. 2003 May;34(4):265-8 - PubMed
  24. Clin Neuropharmacol. 2003 Mar-Apr;26(2):65-72 - PubMed
  25. J Neurochem. 2003 Jun;85(5):1101-8 - PubMed
  26. Exp Neurol. 2003 Jul;182(1):151-9 - PubMed
  27. J Pineal Res. 2003 Sep;35(2):80-4 - PubMed
  28. J Pineal Res. 2003 Sep;35(2):98-103 - PubMed
  29. J Nippon Med Sch. 2003 Aug;70(4):334-41 - PubMed
  30. Neurosurg Rev. 2004 Jan;27(1):65-9 - PubMed
  31. Am J Hosp Pharm. 1992 Aug;49(8):2006-8 - PubMed
  32. Sleep Med. 2003 Jul;4(4):281-4 - PubMed
  33. FASEB J. 2004 Jan;18(1):149-51 - PubMed
  34. Sleep. 2003 Nov 1;26(7):893-901 - PubMed
  35. J Pineal Res. 2004 Jan;36(1):33-42 - PubMed
  36. Am J Med. 2004 Jan 15;116(2):91-5 - PubMed
  37. Acta Pharmacol Sin. 2004 Mar;25(3):276-80 - PubMed
  38. FASEB J. 2004 Mar;18(3):511-8 - PubMed
  39. J Pineal Res. 2004 Apr;36(3):186-91 - PubMed
  40. Photochem Photobiol. 2004 Apr;79(4):316-8 - PubMed
  41. J Clin Psychopharmacol. 2004 Aug;24(4):456-9 - PubMed
  42. Am J Geriatr Psychiatry. 2004 Jul-Aug;12(4):432-6 - PubMed
  43. J Pineal Res. 2004 Sep;37(2):129-36 - PubMed
  44. Clin Ter. 2004 Apr;155(4):127-33 - PubMed
  45. Arch Gerontol Geriatr. 1999 Mar-Apr;28(2):85-98 - PubMed
  46. Free Radic Biol Med. 2004 Dec 1;37(11):1790-801 - PubMed
  47. J Neuroendocrinol. 2004 Nov;16(11):929-35 - PubMed
  48. Pharmacol Biochem Behav. 2005 Jan;80(1):9-26 - PubMed
  49. Sheng Li Xue Bao. 2005 Feb 25;57(1):7-12 - PubMed
  50. Brain Res. 2005 Mar 10;1037(1-2):209-13 - PubMed
  51. J Neuroendocrinol. 2005 Mar;17(3):170-8 - PubMed
  52. Acta Pharmacol Sin. 2005 May;26(5):519-26 - PubMed
  53. Sleep Med. 2005 Sep;6(5):459-66 - PubMed
  54. Free Radic Biol Med. 2006 Jan 1;40(1):101-9 - PubMed
  55. Brain Res. 2006 Jan 12;1068(1):230-6 - PubMed
  56. Br J Psychiatry. 2006 Feb;188:109-21 - PubMed
  57. Blood. 2006 Jul 15;108(2):518-24 - PubMed
  58. Chronobiol Int. 2006;23(1-2):403-12 - PubMed
  59. Lancet Neurol. 2006 Jul;5(7):572-7 - PubMed
  60. J Pineal Res. 2006 Oct;41(3):238-46 - PubMed
  61. J Pineal Res. 2006 Nov;41(4):313-23 - PubMed
  62. Indian J Med Res. 2006 Oct;124(4):419-26 - PubMed
  63. J Clin Endocrinol Metab. 1992 Jan;74(1):108-17 - PubMed
  64. Endocrinology. 1992 Feb;130(2):701-7 - PubMed
  65. J Pineal Res. 2007 Apr;42(3):247-53 - PubMed
  66. J Neurol. 2007 Apr;254(4):459-64 - PubMed
  67. Z Gerontol Geriatr. 2007 Jun;40(3):178-84 - PubMed
  68. Chronobiol Int. 2007;24(3):521-37 - PubMed
  69. J Pineal Res. 2007 Sep;43(2):163-71 - PubMed
  70. Curr Med Res Opin. 2007 Oct;23(10):2597-605 - PubMed
  71. J Pineal Res. 2007 Nov;43(4):404-9 - PubMed
  72. FASEB J. 2008 Mar;22(3):659-61 - PubMed
  73. J Am Geriatr Soc. 2008 Feb;56(2):239-46 - PubMed
  74. Experientia. 1991 May 15;47(5):466-9 - PubMed
  75. Clin Neurol Neurosurg. 2008 May;110(5):492-5 - PubMed
  76. Neurosci Lett. 2008 May 16;436(3):309-13 - PubMed
  77. JAMA. 2008 Jun 11;299(22):2642-55 - PubMed
  78. Prog Neurobiol. 2008 Jul;85(3):335-53 - PubMed
  79. J Pain. 2009 Jan;10(1):100-8 - PubMed
  80. Rev Neurosci. 2008;19(4-5):245-316 - PubMed
  81. Am J Geriatr Psychiatry. 2009 Feb;17(2):166-9 - PubMed
  82. Aging Clin Exp Res. 2009 Feb;21(1):38-42 - PubMed
  83. Acad Pediatr. 2009 Mar-Apr;9(2):81-8 - PubMed
  84. Hippocampus. 2010 Jan;20(1):218-25 - PubMed
  85. J Neurosci Res. 2009 Oct;87(13):3002-10 - PubMed
  86. J Neurochem. 2009 Jun;109(5):1400-12 - PubMed
  87. J Pineal Res. 2009 Aug;47(1):82-96 - PubMed
  88. Toxicology. 2009 Nov 9;265(1-2):49-55 - PubMed
  89. Neurotox Res. 2010 May;17(4):421-31 - PubMed
  90. J Clin Sleep Med. 2009 Jun 15;5(3):235-9 - PubMed
  91. Med Sci Monit. 2010 Feb;16(2):BR61-7 - PubMed
  92. J Clin Sleep Med. 2010 Feb 15;6(1):85-95 - PubMed
  93. J Sleep Res. 2010 Dec;19(4):591-6 - PubMed
  94. Pharmacol Rev. 2010 Sep;62(3):343-80 - PubMed
  95. Ann N Y Acad Sci. 2010 Jun;1199:105-13 - PubMed
  96. J Psychopharmacol. 2010 Nov;24(11):1577-601 - PubMed
  97. J Pineal Res. 2011 Mar;50(2):97-109 - PubMed
  98. Prog Neurobiol. 2011 Mar;93(3):350-84 - PubMed
  99. J Pineal Res. 2011 Apr;50(3):319-27 - PubMed
  100. Pharmacoepidemiol Drug Saf. 2011 Feb;20(2):177-84 - PubMed
  101. J Pineal Res. 2011 Aug;51(1):75-86 - PubMed
  102. Curr Neuropharmacol. 2010 Sep;8(3):194-210 - PubMed
  103. Curr Neuropharmacol. 2010 Sep;8(3):218-27 - PubMed
  104. Front Neurol. 2011 Mar 16;2:13 - PubMed
  105. J Pineal Res. 2011 May;50(4):381-8 - PubMed
  106. Clin Biochem. 2011 Jul;44(10-11):853-8 - PubMed
  107. Food Chem Toxicol. 2011 Aug;49(8):1773-81 - PubMed
  108. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11686-91 - PubMed
  109. Pharmacol Biochem Behav. 2011 Oct;99(4):704-11 - PubMed
  110. J Pineal Res. 2011 Aug;51(1):1-16 - PubMed
  111. J Pineal Res. 2012 Jan;52(1):128-37 - PubMed
  112. Neurobiol Aging. 2012 Jun;33(6):1124.e13-29 - PubMed
  113. J Pineal Res. 2012 Apr;52(3):312-21 - PubMed
  114. Neurosci Lett. 2012 Mar 5;511(1):47-51 - PubMed
  115. Nutr Neurosci. 2012 Mar;15(2):46-54 - PubMed
  116. ISRN Neurol. 2012;2012:360379 - PubMed
  117. J Physiol. 2012 Jul 1;590(13):3103-12 - PubMed
  118. Neuromolecular Med. 2012 Sep;14(3):194-204 - PubMed
  119. J Pharmacol Sci. 2012;119(2):177-85 - PubMed
  120. Arch Ital Biol. 2012 Mar;150(1):5-14 - PubMed
  121. Chronobiol Int. 2012 Aug;29(7):822-34 - PubMed
  122. Sci Transl Med. 2012 Aug 15;4(147):147ra111 - PubMed
  123. Neuropharmacology. 2012 Dec;63(8):1368-79 - PubMed
  124. Exp Gerontol. 2012 Dec;47(12):974-8 - PubMed
  125. Psychopharmacology (Berl). 1990;100(2):222-6 - PubMed
  126. J Pineal Res. 2013 Apr;54(3):313-21 - PubMed
  127. Psychogeriatrics. 2012 Dec;12(4):259-62 - PubMed
  128. Sleep Med. 2013 Mar;14(3):237-42 - PubMed
  129. Am J Neurodegener Dis. 2012;1(3):280-91 - PubMed
  130. Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(12):26-30 - PubMed
  131. Histol Histopathol. 2013 Aug;28(8):999-1006 - PubMed
  132. Int J Mol Sci. 2013 Apr 22;14(4):8638-83 - PubMed
  133. PLoS One. 2013 May 17;8(5):e63773 - PubMed
  134. Sleep Med. 2013 Aug;14(8):795-806 - PubMed
  135. J Pineal Res. 2013 Oct;55(3):304-12 - PubMed
  136. Biogerontology. 2013 Dec;14(6):753-62 - PubMed
  137. Pharmacol Rep. 2013;65(5):1213-26 - PubMed
  138. Cell Mol Life Sci. 2014 Aug;71(16):2997-3025 - PubMed
  139. JAMA Neurol. 2014 Apr;71(4):463-9 - PubMed
  140. J Pineal Res. 2014 May;56(4):427-38 - PubMed
  141. Food Chem Toxicol. 2014 Jul;69:320-9 - PubMed
  142. J Pineal Res. 2014 Sep;57(2):213-8 - PubMed
  143. Clin Interv Aging. 2014 Jun 18;9:947-61 - PubMed
  144. Int J Mol Sci. 2014 Sep 09;15(9):15858-90 - PubMed
  145. Neurochem Int. 2014 Dec;79:1-11 - PubMed
  146. Brain Res. 2014 Dec 17;1593:95-105 - PubMed
  147. J Neurosci. 2014 Dec 3;34(49):16180-93 - PubMed
  148. J Pineal Res. 2015 Mar;58(2):151-65 - PubMed
  149. Biogerontology. 2015 Jun;16(3):303-16 - PubMed
  150. J Pineal Res. 2015 Mar;58(2):173-7 - PubMed
  151. Am J Alzheimers Dis Other Demen. 2015 Aug;30(5):439-47 - PubMed
  152. J Pineal Res. 2015 Apr;58(3):262-74 - PubMed
  153. Free Radic Res. 2015;49(8):1004-14 - PubMed
  154. Brain. 2015 May;138(Pt 5):1131-3 - PubMed
  155. Crit Care Med. 2015 Aug;43(8):1612-21 - PubMed
  156. ACS Chem Neurosci. 2015 Aug 19;6(8):1393-1399 - PubMed
  157. Neurochirurgie. 2015 Apr-Jun;61(2-3):77-84 - PubMed
  158. Neurochem Res. 2015 Dec;40(12):2583-99 - PubMed
  159. J Psychiatr Res. 2015 Sep;68:392-6 - PubMed
  160. J Pineal Res. 2015 Sep;59(2):133-50 - PubMed
  161. J Pineal Res. 2015 Oct;59(3):308-20 - PubMed
  162. J Clin Pharmacol. 2016 Mar;56(3):324-9 - PubMed
  163. Neurol Sci. 2016 Jan;37(1):57-65 - PubMed
  164. J Pineal Res. 2015 Nov;59(4):403-19 - PubMed
  165. Plant Signal Behav. 2015;10(11):e1096469 - PubMed
  166. Sleep Med. 2015 Oct;16(10):1245-51 - PubMed
  167. Turk J Med Sci. 2015;45(5):1073-7 - PubMed
  168. Brain Res. 2016 Feb 15;1633:115-125 - PubMed
  169. Brain Pathol. 2017 Mar;27(2):160-168 - PubMed
  170. Neuron. 2016 May 18;90(4):675-91 - PubMed
  171. Curr Treat Options Neurol. 2016 Sep;18(9):40 - PubMed
  172. Trends Neurosci. 2016 Nov;39(11):750-762 - PubMed
  173. Oxid Med Cell Longev. 2016;2016:3472032 - PubMed
  174. Mol Neurodegener. 2016 Dec 8;11(1):74 - PubMed
  175. Maturitas. 2017 Feb;96:103-108 - PubMed
  176. J Clin Pharm Ther. 2017 Jun;42(3):251-258 - PubMed
  177. J Neural Transm (Vienna). 2018 Mar;125(3):385-400 - PubMed
  178. Brain Struct Funct. 2017 Sep;222(7):2921-2939 - PubMed
  179. J Clin Anesth. 2017 Jun;39:77-81 - PubMed
  180. Curr Alzheimer Res. 2017;14(10):1084-1089 - PubMed
  181. Biofactors. 2017 Jul 8;43(4):593-611 - PubMed
  182. Sleep Med Rev. 2017 Aug;34:10-22 - PubMed
  183. Br J Pharmacol. 2018 Aug;175(16):3263-3280 - PubMed
  184. PLoS One. 2017 Aug 11;12(8):e0183090 - PubMed
  185. J Neural Transm (Vienna). 2018 Mar;125(3):337-363 - PubMed
  186. Cell Mol Life Sci. 2017 Nov;74(21):3863-3881 - PubMed
  187. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7997-E8006 - PubMed
  188. Mol Cells. 2017 Sep 30;40(9):613-620 - PubMed
  189. Brain Res. 2018 Jan 1;1678:203-213 - PubMed
  190. Ageing Res Rev. 2017 Nov;40:149-167 - PubMed
  191. Chin Med J (Engl). 2017 Nov 20;130(22):2726-2731 - PubMed
  192. Life Sci. 2018 Jan 1;192:238-245 - PubMed
  193. Yeast. 2018 Mar;35(3):281-290 - PubMed
  194. J Pineal Res. 2018 Apr;64(3):null - PubMed
  195. Annu Rev Pathol. 2018 Jan 24;13:379-394 - PubMed
  196. Geroscience. 2017 Dec;39(5-6):499-550 - PubMed
  197. Biol Psychiatry. 2018 Feb 15;83(4):328-336 - PubMed
  198. J Pineal Res. 2018 May;64(4):e12470 - PubMed
  199. Ageing Res Rev. 2018 May;43:81-98 - PubMed
  200. Curr Alzheimer Res. 2018;15(7):637-642 - PubMed
  201. Int Rev Cell Mol Biol. 2018;338:59-77 - PubMed
  202. Int J Clin Pharm. 2018 Jun;40(3):509-512 - PubMed
  203. Cent Nerv Syst Agents Med Chem. 2018;18(2):102-114 - PubMed
  204. Neuropsychobiology. 2017;76(2):100-104 - PubMed
  205. Front Neuroendocrinol. 2019 Jan;52:22-28 - PubMed
  206. Nat Rev Drug Discov. 2018 Sep;17(9):660-688 - PubMed
  207. Int J Mol Sci. 2018 Aug 18;19(8):null - PubMed
  208. J Pineal Res. 2018 Nov;65(4):e12525 - PubMed
  209. Parkinsonism Relat Disord. 2019 Apr;61:203-206 - PubMed
  210. Neurology. 1988 Nov;38(11):1688-93 - PubMed
  211. J Parkinsons Dis. 2018;8(s1):S73-S78 - PubMed
  212. Biomed Pharmacother. 2019 Mar;111:765-777 - PubMed
  213. Ann N Y Acad Sci. 2019 May;1443(1):75-96 - PubMed
  214. Expert Rev Endocrinol Metab. 2008 Mar;3(2):269-279 - PubMed
  215. Life Sci I. 1971 Aug 1;10(15):841-50 - PubMed
  216. Endocr Rev. 1981 Summer;2(3):327-46 - PubMed
  217. Psychopharmacol Bull. 1984 Summer;20(3):561-5 - PubMed
  218. J Pharmacol Exp Ther. 1983 Dec;227(3):587-91 - PubMed
  219. Brain Res. 1982 Aug 19;246(1):161-3 - PubMed
  220. Eur J Pharmacol. 1980 Oct 3;67(1):151-3 - PubMed
  221. Neurobiol Aging. 1995 May-Jun;16(3):271-8; discussion 278-84 - PubMed
  222. Am J Physiol. 1995 Jul;269(1 Pt 1):E85-90 - PubMed
  223. J Neural Transm Park Dis Dement Sect. 1993;5(3):227-34 - PubMed
  224. Biochim Biophys Acta. 1996 Jun 4;1290(2):191-6 - PubMed
  225. FASEB J. 1996 Jun;10(8):891-6 - PubMed
  226. Neuroreport. 1996 Jan 31;7(2):597-600 - PubMed
  227. Pharmacol Ther. 1996;69(1):15-36 - PubMed
  228. Neurosci Biobehav Rev. 1996 Autumn;20(3):403-12 - PubMed
  229. Life Sci. 1997;60(2):PL23-9 - PubMed
  230. Neuroendocrinology. 1997 Apr;65(4):276-83 - PubMed
  231. J Clin Endocrinol Metab. 1977 Oct;45(4):768-74 - PubMed
  232. Brain Res. 1997 May 2;755(2):335-8 - PubMed
  233. Neurosci Lett. 1997 Jul 4;229(3):193-7 - PubMed
  234. J Appl Physiol (1985). 1997 Aug;83(2):354-8 - PubMed
  235. Exp Gerontol. 1997 Jul-Oct;32(4-5):553-8 - PubMed
  236. J Pineal Res. 1997 Aug;23(1):40-6 - PubMed
  237. Neuropsychobiology. 1997;36(4):211-4 - PubMed
  238. J Biol Rhythms. 1997 Dec;12(6):657-65 - PubMed
  239. J Biol Chem. 1998 Mar 27;273(13):7185-8 - PubMed
  240. Neurosci Lett. 1998 Apr 3;245(2):61-4 - PubMed
  241. Neuroreport. 1998 Jul 13;9(10):2387-90 - PubMed
  242. J Neural Transm Suppl. 1998;53:127-40 - PubMed
  243. J Pineal Res. 1998 Oct;25(3):177-83 - PubMed
  244. Eur J Pharmacol. 1998 Dec 11;363(1):57-63 - PubMed
  245. J Pineal Res. 1998 Dec;25(4):260-3 - PubMed
  246. J Clin Endocrinol Metab. 1999 Jan;84(1):323-7 - PubMed
  247. Neuroreport. 1998 Dec 21;9(18):4123-6 - PubMed

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