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Sabbadin C, Bordin L, Donà G, et al. Licorice: From Pseudohyperaldosteronism to Therapeutic Uses. Front Endocrinol (Lausanne). 2019;10:484doi: 10.3389/fendo.2019.00484.
Sabbadin, C., Bordin, L., Donà, G., Manso, J., Avruscio, G., & Armanini, D. (2019). Licorice: From Pseudohyperaldosteronism to Therapeutic Uses. Frontiers in endocrinology, 10484. https://doi.org/10.3389/fendo.2019.00484
Sabbadin, Chiara, et al. "Licorice: From Pseudohyperaldosteronism to Therapeutic Uses." Frontiers in endocrinology vol. 10 (2019): 484. doi: https://doi.org/10.3389/fendo.2019.00484
Sabbadin C, Bordin L, Donà G, Manso J, Avruscio G, Armanini D. Licorice: From Pseudohyperaldosteronism to Therapeutic Uses. Front Endocrinol (Lausanne). 2019 Jul 18;10:484. doi: 10.3389/fendo.2019.00484. eCollection 2019. PMID: 31379750; PMCID: PMC6657287.
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Front Endocrinol (Lausanne). 2019 Jul 18;10:484. doi: 10.3389/fendo.2019.00484. eCollection 2019.

Licorice: From Pseudohyperaldosteronism to Therapeutic Uses.

Frontiers in endocrinology

Chiara Sabbadin, Luciana Bordin, Gabriella Donà, Jacopo Manso, Giampiero Avruscio, Decio Armanini

Affiliations

  1. Endocrinology Unit, Department of Medicine, University Hospital of Padua, Padua, Italy.
  2. Department of Molecular Medicine-Biological Chemistry, University of Padua, Padua, Italy.
  3. Angiology Unit, Department of Cardiac, Thoracic and Vascular Sciences, University Hospital of Padua, Padua, Italy.

PMID: 31379750 PMCID: PMC6657287 DOI: 10.3389/fendo.2019.00484

Abstract

Licorice has been used as a medicinal plant from 2.500 years. It shows a wide range of biological and pharmacological activities, including anti-inflammatory and immune regulatory actions. One of its most known effects is the induction of hypertension, and it can induce what appears to be pseudohyperaldosteronism, due to glycyrrhetinic acid, the main active component of the root. Glycyrrhetinic acid and metabolites block the 11 beta-hydroxysteroid dehydrogenase type 2 and also bind mineralocorticoid receptors directly, acting as agonists. However, other interesting therapeutic uses of licorice are linked to its anti-androgen and estrogen-like activity, especially in the treatment of polycystic ovary syndrome (PCOS) in conjunction with spironolactone therapy. In this brief review, we report the main features and possible therapeutic uses of this ancient plant.

Keywords: aldosterone; glycyrrhetinic acid (GA); hypertension; inflammation; licorice; polycystic ovary syndrome (PCOS); pseudohyperaldosteronism

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