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Ishibashi K, Iwai H, Koga H. Chemonucleolysis with chondroitin sulfate ABC endolyase as a novel minimally invasive treatment for patients with lumbar intervertebral disc herniation. J Spine Surg. 2019;5:S115-S121doi: 10.21037/jss.2019.04.24.
Ishibashi, K., Iwai, H., & Koga, H. (2019). Chemonucleolysis with chondroitin sulfate ABC endolyase as a novel minimally invasive treatment for patients with lumbar intervertebral disc herniation. Journal of spine surgery (Hong Kong), 5S115-S121. https://doi.org/10.21037/jss.2019.04.24
Ishibashi, Katsuhiko, et al. "Chemonucleolysis with chondroitin sulfate ABC endolyase as a novel minimally invasive treatment for patients with lumbar intervertebral disc herniation." Journal of spine surgery (Hong Kong) vol. 5 (2019): S115-S121. doi: https://doi.org/10.21037/jss.2019.04.24
Ishibashi K, Iwai H, Koga H. Chemonucleolysis with chondroitin sulfate ABC endolyase as a novel minimally invasive treatment for patients with lumbar intervertebral disc herniation. J Spine Surg. 2019 Jun;5:S115-S121. doi: 10.21037/jss.2019.04.24. PMID: 31380500; PMCID: PMC6626749.
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J Spine Surg. 2019 Jun;5:S115-S121. doi: 10.21037/jss.2019.04.24.

Chemonucleolysis with chondroitin sulfate ABC endolyase as a novel minimally invasive treatment for patients with lumbar intervertebral disc herniation.

Journal of spine surgery (Hong Kong)

Katsuhiko Ishibashi, Hiroki Iwai, Hisashi Koga

Affiliations

  1. Department of Orthopaedic Surgery, Iwai Orthopaedic Medical Hospital, Tokyo, Japan.
  2. Department of Orthopaedic Surgery, Inanami Spine and Joint Hospital, Tokyo, Japan.
  3. Iwai FESS Clinics, Tokyo, Japan.

PMID: 31380500 PMCID: PMC6626749 DOI: 10.21037/jss.2019.04.24

Abstract

Chemonucleolysis is a minimally invasive treatment for cervical and lumbar intervertebral disc herniation (IDH). While this procedure has existed for more than 50 years, it has yet to become an established practice. The main reason for this is the low specificity of enzymes targeting nucleus pulposus (NP). Although two enzymes (chymopapain and collagenase) have been used in clinical settings, severe adverse events have discouraged widespread use. The recently introduced enzyme

Keywords: Chemonucleolysis; Proteus vulgaris chondroitin sulfate ABC endolyase; intervertebral disc herniation (IDH); minimally invasive

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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