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Huang KL, Wang SY, Lu WC, et al. Effects of low-dose computed tomography on lung cancer screening: a systematic review, meta-analysis, and trial sequential analysis. BMC Pulm Med. 2019;19(1):126doi: 10.1186/s12890-019-0883-x.
Huang, K. L., Wang, S. Y., Lu, W. C., Chang, Y. H., Su, J., & Lu, Y. T. (2019). Effects of low-dose computed tomography on lung cancer screening: a systematic review, meta-analysis, and trial sequential analysis. BMC pulmonary medicine, 19(1), 126. https://doi.org/10.1186/s12890-019-0883-x
Huang, Kai-Lin, et al. "Effects of low-dose computed tomography on lung cancer screening: a systematic review, meta-analysis, and trial sequential analysis." BMC pulmonary medicine vol. 19,1 (2019): 126. doi: https://doi.org/10.1186/s12890-019-0883-x
Huang KL, Wang SY, Lu WC, Chang YH, Su J, Lu YT. Effects of low-dose computed tomography on lung cancer screening: a systematic review, meta-analysis, and trial sequential analysis. BMC Pulm Med. 2019 Jul 11;19(1):126. doi: 10.1186/s12890-019-0883-x. PMID: 31296196; PMCID: PMC6625016.
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BMC Pulm Med. 2019 Jul 11;19(1):126. doi: 10.1186/s12890-019-0883-x.

Effects of low-dose computed tomography on lung cancer screening: a systematic review, meta-analysis, and trial sequential analysis.

BMC pulmonary medicine

Kai-Lin Huang, Shih-Yuan Wang, Wan-Chen Lu, Ya-Hui Chang, Jian Su, Yen-Ta Lu

Affiliations

  1. Department of Pharmacy, MacKay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City, 10449, Taiwan.
  2. Mackay Junior College of Medicine, Nursing, and Management, No. 92, Shengjing Road, Beitou District, Taipei, 11272, Taiwan.
  3. Department of Chest Medicine, MacKay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City, 10449, Taiwan. [email protected].
  4. Department of Medicine, Mackay Medical College, No. 46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei City, 252, Taiwan. [email protected].
  5. Department of Chest Medicine, MacKay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City, 10449, Taiwan. [email protected].
  6. Department of Medicine, Mackay Medical College, No. 46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei City, 252, Taiwan. [email protected].

PMID: 31296196 PMCID: PMC6625016 DOI: 10.1186/s12890-019-0883-x

Abstract

BACKGROUND: The Nelson mortality results were presented in September 2018. Four other randomized control trials (RCTs) were also reported the latest mortality outcomes in 2018 and 2019. We therefore conducted a meta-analysis to update the evidence and investigate the benefits and harms of low-dose computed tomography (LDCT) in lung cancer screening.

METHODS: Detailed electronic database searches were performed to identify reports of RCTs that comparing LDCT to any other type of lung cancer screening. Pooled risk ratios (RRs) were calculated using random effects models.

RESULTS: We identified nine RCTs (n = 97,244 participants). In pooled analyses LDCT reduced lung cancer mortality (RR 0.83, 95% CI 0.76-0.90, I

CONCLUSIONS: In meta-analysis based on sufficient evidence demonstrated by TSA suggests that LDCT screening is superiority over usual care in lung cancer survival. The benefit of LDCT is expected to be heavily influenced by the risk of lung cancer in the different target group (smoking status, Asian) being screened.

Keywords: LDCT; Low-dose computed tomography; Lung cancer screening; Meta-analysis; Mortality

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