Korean J Pediatr. 2019 Nov;62(11):416-421. doi: 10.3345/kjp.2019.00563. Epub 2019 Aug 12.
Association between Body Mass Index and Hepatitis B antibody seropositivity in children.
Korean journal of pediatrics
Yoowon Kwon, Su Jin Jeong
Affiliations
Affiliations
- Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
PMID: 31401825
PMCID: PMC6881202 DOI: 10.3345/kjp.2019.00563
Abstract
BACKGROUND: The seropositivity rate of hepatitis B surface antigen (anti-HBs) antibodies is known to be ≥95% after hepatitis B virus vaccination during infancy. However, a low level or absence of anti-HBs in healthy children is discovered in many cases. Recent studies in adults reported that a reduced anti-HBs production rate is related to obesity.
PURPOSE: To investigate whether body mass index (BMI) affects anti-HBs levels in healthy children following 3 serial dose vaccinations in infancy.
METHODS: We recruited 1,200 healthy volunteers aged 3, 5, 7, or 10 years from 4-day care centers and 4 elementary schools. All subjects completed a questionnaire including body weight, height, and vaccine type received. Levels of serum hepatitis B surface antigen (HBsAg) and anti-HBs in all subjects were analyzed using electrochemiluminescence immunoassay. The standardized scores (z score) for each sex and age were obtained using the lambda-mu-sigma method in the 2017 Korean National Growth Charts for children and adolescents.
RESULTS: Our subjects (n=1,200) comprised 750 males (62.5%) and 450 females (37.5%). The overall anti-HBs seropositivity rate was 57.9% (695 of 1,200). We identified significant differences in mean BMI values between seronegative and seropositive groups (17.45 vs. 16.62, respectively; P<0.001). The anti-HBs titer was significantly decreased as the BMI z score increased adjusting for age and sex (B=-15.725; standard error=5.494; P=0.004). The probability of anti-HBs seropositivity based on BMI z score was decreased to an OR of 0.820 after the control for confounding variables (95% confidence interval, 0.728-0.923; P=0.001).
CONCLUSION: There was a significant association between anti-HBs titer and BMI z score after adjustment for age and sex. Our results indicate that BMI is a potential factor affecting anti-HBs titer in healthy children.
Keywords: Anti-HBs; BMI z score; Child; Hepatitis B; Seropositivity rate
References
- Vaccine. 2016 May 23;34(24):2745-9 - PubMed
- Taehan Kan Hakhoe Chi. 2003 Dec;9(4):304-14 - PubMed
- PLoS One. 2013 Dec 11;8(12):e82779 - PubMed
- MMWR Morb Mortal Wkly Rep. 2009 Jul 17;58(27):749-52 - PubMed
- JAMA. 1997 Jun 4;277(21):1709-11 - PubMed
- JAMA. 1985 Dec 13;254(22):3187-9 - PubMed
- Vaccine. 2014 Feb 12;32(8):979-83 - PubMed
- Hum Vaccin Immunother. 2018 Feb 1;14(2):456-463 - PubMed
- Vaccine. 2016 Sep 14;34(40):4835-41 - PubMed
- J Korean Med Sci. 2017 May;32(5):810-816 - PubMed
- Vaccine. 2015 Aug 26;33(36):4422-9 - PubMed
- Iran Biomed J. 2016 Nov 2;21(3):197-202 - PubMed
- Exp Biol Med (Maywood). 2010 Dec;235(12):1412-24 - PubMed
- J Res Med Sci. 2017 Oct 31;22:116 - PubMed
- Vaccine. 1989 Oct;7(5):425-30 - PubMed
- Clin Microbiol Infect. 2014 Oct;20(10):O680-6 - PubMed
- Vaccine. 1996 Feb;14(2):103-6 - PubMed
- Autoimmunity. 2006 Mar;39(2):137-41 - PubMed
- Vaccine. 1996 Jan;14(1):25-7 - PubMed
- Proc Nutr Soc. 2012 May;71(2):298-306 - PubMed
Publication Types