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Chau LTM, Tu DK, Lehert P, et al. Clinical pregnancy following GnRH agonist administration in the luteal phase of fresh or frozen assisted reproductive technology (ART) cycles: Systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol X. 2019;3:100046doi: 10.1016/j.eurox.2019.100046.
Chau, L. T. M., Tu, D. K., Lehert, P., Dung, D. V., Thanh, L. Q., & Tuan, V. M. (2019). Clinical pregnancy following GnRH agonist administration in the luteal phase of fresh or frozen assisted reproductive technology (ART) cycles: Systematic review and meta-analysis. European journal of obstetrics & gynecology and reproductive biology: X, 3100046. https://doi.org/10.1016/j.eurox.2019.100046
Chau, Le Thi Minh, et al. "Clinical pregnancy following GnRH agonist administration in the luteal phase of fresh or frozen assisted reproductive technology (ART) cycles: Systematic review and meta-analysis." European journal of obstetrics & gynecology and reproductive biology: X vol. 3 (2019): 100046. doi: https://doi.org/10.1016/j.eurox.2019.100046
Chau LTM, Tu DK, Lehert P, Dung DV, Thanh LQ, Tuan VM. Clinical pregnancy following GnRH agonist administration in the luteal phase of fresh or frozen assisted reproductive technology (ART) cycles: Systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol X. 2019 May 13;3:100046. doi: 10.1016/j.eurox.2019.100046. eCollection 2019 Jul. PMID: 31403130; PMCID: PMC6687475.
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Eur J Obstet Gynecol Reprod Biol X. 2019 May 13;3:100046. doi: 10.1016/j.eurox.2019.100046. eCollection 2019 Jul.

Clinical pregnancy following GnRH agonist administration in the luteal phase of fresh or frozen assisted reproductive technology (ART) cycles: Systematic review and meta-analysis.

European journal of obstetrics & gynecology and reproductive biology: X

Le Thi Minh Chau, Duong Khue Tu, Philippe Lehert, Do Van Dung, Le Quang Thanh, Vo Minh Tuan

Affiliations

  1. Department of Infertility, Tu Du hospital, Vietnam.
  2. Faculty of Medicine, the University of Melbourne, Australia.
  3. Faculty of Economics, UCL Mons, Louvain, Belgium.
  4. University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam.
  5. Tu Du hospital, Vietnam.

PMID: 31403130 PMCID: PMC6687475 DOI: 10.1016/j.eurox.2019.100046

Abstract

OBJECTIVES: To study if the GnRH agonist administration in luteal phase improves clinical pregnancy rate of fresh and frozen embryo transfer. Also, this meta-analysis compares the treatment effect of luteal GnRH agonist administration between long agonist and antagonist protocols of fresh cycles, and between two types of treatment: fresh and frozen embryo transfers.

STUDY DESIGN: Systematic review and meta-analysis (registration number CRD42017059152).

RESULTS: For the overall 20 studies (5497 patients), clinical pregnancy rate significantly increased in group of GnRH agonist administration compared to control group (RR 1.24, 95% CI 1.14-1.34, p < 0.0001). Regarding the treatment effect of luteal GnRH agonist administration between long agonist and antagonist protocol fresh cycles, no significant difference was observed (RR = 1.28, 95% CI 0.98-1.67, p = 0.07). Also, in comparison between fresh and frozen embryo transfer, similar effect of GnRH agonist administration was found (RR = 0.93, 95% CI 0.74-1.16, p = 0.49).

CONCLUSIONS: There is evidence that GnRH agonist administration in luteal phase improve clinical pregnancy rate in both fresh and frozen cycles. Within fresh cycles, no significant difference of clinical pregnancy rate is found between two protocols. In frozen cycles, the effect of GnRH agonist administration in enhancing clinical pregnancy rate is similar to fresh cycles.

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