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Kelmendi B, Adams TG, Southwick S, et al. Posttraumatic Stress Disorder: an integrated overview and neurobiological rationale for pharmacology. Clin Psychol (New York). 2017;24(3):281-297doi: 10.1111/cpsp.12202.
Kelmendi, B., Adams, T. G., Southwick, S., Abdallah, C. G., & Krystal, J. H. (2017). Posttraumatic Stress Disorder: an integrated overview and neurobiological rationale for pharmacology. Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association, 24(3), 281-297. https://doi.org/10.1111/cpsp.12202
Kelmendi, Benjamin, et al. "Posttraumatic Stress Disorder: an integrated overview and neurobiological rationale for pharmacology." Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association vol. 24,3 (2017): 281-297. doi: https://doi.org/10.1111/cpsp.12202
Kelmendi B, Adams TG, Southwick S, Abdallah CG, Krystal JH. Posttraumatic Stress Disorder: an integrated overview and neurobiological rationale for pharmacology. Clin Psychol (New York). 2017 Sep;24(3):281-297. doi: 10.1111/cpsp.12202. Epub 2017 Jul 18. PMID: 31404451; PMCID: PMC6688474.
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Clin Psychol (New York). 2017 Sep;24(3):281-297. doi: 10.1111/cpsp.12202. Epub 2017 Jul 18.

Posttraumatic Stress Disorder: an integrated overview and neurobiological rationale for pharmacology.

Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association

Benjamin Kelmendi, Thomas G Adams, Steven Southwick, Chadi G Abdallah, John H Krystal

Affiliations

  1. Clinical Neuroscience Division, Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Healthcare System, West Haven, CT.
  2. Department of Psychiatry, Yale University School of Medicine, New Haven, CT.
  3. Department of Neuroscience, Yale University School of Medicine, New Haven, CT.
  4. Psychiatry Services, Yale-New Haven Hospital, New Haven, CT.

PMID: 31404451 PMCID: PMC6688474 DOI: 10.1111/cpsp.12202

Abstract

Thirty years of research on the biology of posttraumatic stress disorder now provides a foundation for hypotheses related to the mechanisms underlying the pharmacotherapy of this disorder. Only two medications, sertraline and paroxetine, are approved by the U.S. Food and Drug Administration for the treatment of PTSD. While these medications are somewhat effective, other treatment mechanisms must be explored to address the unmet need for effective treatment. This article provides a concise summary of advances in our understanding of the neurobiology of PTSD that suggest novel approaches to pharmacotherapy.

Keywords: GABA; PTSD; glutamate; noradrenergic; pharmacology; serotonin

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