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Chai KY, Quijano CJ, Chiruka S. Danazol: An Effective and Underutilised Treatment Option in Diamond-Blackfan Anaemia. Case Rep Hematol. 2019;2019:4684156doi: 10.1155/2019/4684156.
Chai, K. Y., Quijano, C. J., & Chiruka, S. (2019). Danazol: An Effective and Underutilised Treatment Option in Diamond-Blackfan Anaemia. Case reports in hematology, 20194684156. https://doi.org/10.1155/2019/4684156
Chai, Kern Y, et al. "Danazol: An Effective and Underutilised Treatment Option in Diamond-Blackfan Anaemia." Case reports in hematology vol. 2019 (2019): 4684156. doi: https://doi.org/10.1155/2019/4684156
Chai KY, Quijano CJ, Chiruka S. Danazol: An Effective and Underutilised Treatment Option in Diamond-Blackfan Anaemia. Case Rep Hematol. 2019 Jul 01;2019:4684156. doi: 10.1155/2019/4684156. eCollection 2019. PMID: 31355022; PMCID: PMC6636591.
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Case Rep Hematol. 2019 Jul 01;2019:4684156. doi: 10.1155/2019/4684156. eCollection 2019.

Danazol: An Effective and Underutilised Treatment Option in Diamond-Blackfan Anaemia.

Case reports in hematology

Kern Y Chai, Cara J Quijano, Shingirai Chiruka

Affiliations

  1. Department of Haematology, Dunedin Hospital, 201 Great King Street, Dunedin 9016, New Zealand.

PMID: 31355022 PMCID: PMC6636591 DOI: 10.1155/2019/4684156

Abstract

Diamond-Blackfan anaemia (DBA) is a rare congenital red cell aplasia that presents in infancy. The exact molecular mechanism of ineffective erythropoiesis and red cell aplasia remains unclear, rendering targeted therapy elusive. The mainstay treatment of DBA is with regular blood transfusion and long-term corticosteroids, both of which have long-term side effects. We report a case of DBA successfully treated with danazol, a synthetic androgen, and suggest that danazol be considered as a viable option in patients who become refractory to steroids and are considered high risk or unfit for allogeneic stem cell transplantation.

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