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Keeley TS, Yang S, Lau E. The Diverse Contributions of Fucose Linkages in Cancer. Cancers (Basel). 2019;11(9)doi: 10.3390/cancers11091241.
Keeley, T. S., Yang, S., & Lau, E. (2019). The Diverse Contributions of Fucose Linkages in Cancer. Cancers, 11(9), . https://doi.org/10.3390/cancers11091241
Keeley, Tyler S, et al. "The Diverse Contributions of Fucose Linkages in Cancer." Cancers vol. 11,9 (2019). doi: https://doi.org/10.3390/cancers11091241
Keeley TS, Yang S, Lau E. The Diverse Contributions of Fucose Linkages in Cancer. Cancers (Basel). 2019 Aug 24;11(9). doi: 10.3390/cancers11091241. PMID: 31450600; PMCID: PMC6769556.
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Cancers (Basel). 2019 Aug 24;11(9). doi: 10.3390/cancers11091241.

The Diverse Contributions of Fucose Linkages in Cancer.

Cancers

Tyler S Keeley, Shengyu Yang, Eric Lau

Affiliations

  1. Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA.
  2. University of South Florida Cancer Biology Graduate Program, Tampa, FL 33602, USA.
  3. Department of Tumor Biology, H. Lee Moffitt Cancer Center, Tampa, FL 33602, USA.
  4. Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA. [email protected].
  5. Department of Tumor Biology, H. Lee Moffitt Cancer Center, Tampa, FL 33602, USA. [email protected].

PMID: 31450600 PMCID: PMC6769556 DOI: 10.3390/cancers11091241

Abstract

Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O'- linkages to glycans, and variations in fucosylation linkages, has important implications for cancer biology. This review focuses on the roles that fucosylation plays in cancer, specifically through modulation of cell surface proteins and signaling pathways. How L-fucose and serum fucosylation patterns might be used for future clinical diagnostic, prognostic, and therapeutic approaches will be discussed.

Keywords: cancer; fucose; fucosylation; fucosyltransferase; signal transduction

References

  1. PLoS One. 2013 Oct 09;8(10):e76540 - PubMed
  2. Glycobiology. 2017 Aug 1;27(8):777-786 - PubMed
  3. Biochem Biophys Res Commun. 2008 Dec 19;377(3):792-6 - PubMed
  4. PLoS One. 2011;6(9):e25365 - PubMed
  5. Nat Chem Biol. 2012 Jul;8(7):661-8 - PubMed
  6. Oral Surg Oral Med Oral Pathol. 1988 Apr;65(4):418-20 - PubMed
  7. J Cell Biochem. 2010 Sep 1;111(1):229-38 - PubMed
  8. BMC Complement Altern Med. 2017 Aug 1;17(1):378 - PubMed
  9. Science. 1978 Sep 29;201(4362):1232-3 - PubMed
  10. J Surg Oncol. 1973;5(1):61-9 - PubMed
  11. Front Immunol. 2018 Jul 16;9:1614 - PubMed
  12. J Exp Clin Cancer Res. 2019 Jun 19;38(1):268 - PubMed
  13. Int J Cancer. 2003 Dec 20;107(6):949-57 - PubMed
  14. Br J Cancer. 2013 Dec 10;109(12):3014-22 - PubMed
  15. Am J Pathol. 2004 Feb;164(2):371-83 - PubMed
  16. Front Immunol. 2018 Jan 29;9:78 - PubMed
  17. Mol Immunol. 2008 Apr;45(8):2401-10 - PubMed
  18. J Proteome Res. 2014 Jun 6;13(6):2986-97 - PubMed
  19. Breast Cancer Res. 2017 Oct 5;19(1):111 - PubMed
  20. Cancer Lett. 2016 Nov 1;382(1):44-52 - PubMed
  21. Oncotarget. 2016 Aug 30;7(35):56643-56649 - PubMed
  22. Proteomics. 2008 Aug;8(16):3257-62 - PubMed
  23. J Biol Chem. 1992 Feb 25;267(6):4152-60 - PubMed
  24. Gene. 2016 Mar 10;578(2):232-41 - PubMed
  25. Glycobiology. 2012 Dec;22(12):1684-708 - PubMed
  26. Glycobiology. 2011 Feb;21(2):195-205 - PubMed
  27. Cancer Sci. 2007 Jul;98(7):1000-5 - PubMed
  28. Cancer. 2012 Jun 15;118(12):3036-43 - PubMed
  29. Int J Oncol. 2006 Sep;29(3):557-66 - PubMed
  30. Gastroenterology. 2016 Jun;150(7):1620-1632 - PubMed
  31. Cell Mol Life Sci. 2005 Jan;62(2):171-8 - PubMed
  32. Cell. 2011 Mar 4;144(5):646-74 - PubMed
  33. Glycobiology. 2014 Oct;24(10):935-44 - PubMed
  34. J Int Soc Prev Community Dent. 2015 Nov-Dec;5(6):446-50 - PubMed
  35. PLoS One. 2018 Jun 20;13(6):e0199128 - PubMed
  36. Cancer Lett. 1992 Aug 14;65(2):115-21 - PubMed
  37. Tumour Biol. 2007;28(2):77-83 - PubMed
  38. J Leukoc Biol. 1992 Aug;52(2):188-96 - PubMed
  39. J Biol Chem. 1995 Mar 3;270(9):4632-9 - PubMed
  40. Cancer Sci. 2016 Jun;107(6):734-45 - PubMed
  41. Genes Dev. 1990 Aug;4(8):1288-303 - PubMed
  42. Postepy Hig Med Dosw (Online). 2013 Aug 08;67:828-36 - PubMed
  43. Glycobiology. 1998 Jun;8(6):605-13 - PubMed
  44. Glycoconj J. 2014 Oct;31(6-7):417-26 - PubMed
  45. Med Oncol. 2017 Jan;34(1):9 - PubMed
  46. Sci Rep. 2016 Jun 22;6:27965 - PubMed
  47. Glycobiology. 2003 Jul;13(7):41R-53R - PubMed
  48. Indian J Clin Biochem. 2014 Jul;29(3):345-50 - PubMed
  49. Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8395-E8402 - PubMed
  50. Br J Cancer. 1987 Nov;56(5):605-10 - PubMed
  51. J Biol Chem. 1991 Sep 15;266(26):17467-77 - PubMed
  52. PLoS One. 2014 Sep 18;9(9):e108157 - PubMed
  53. Hepatology. 1991 Apr;13(4):683-8 - PubMed
  54. Proteomics. 2004 Nov;4(11):3353-8 - PubMed
  55. Eur J Immunol. 2019 Aug;49(8):1147-1152 - PubMed
  56. Cell Chem Biol. 2017 Dec 21;24(12):1467-1478.e5 - PubMed
  57. Tumour Biol. 2016 Sep;37(9):12251-12262 - PubMed
  58. Cancer. 2008 Jul 15;113(2):336-46 - PubMed
  59. Oncol Rep. 2016 Aug;36(2):1007-15 - PubMed
  60. Mol Oncol. 2018 May;12(5):579-593 - PubMed
  61. J Cancer. 2017 Jul 3;8(10):1908-1916 - PubMed
  62. Gut. 2015 Apr;64(4):646-56 - PubMed
  63. Front Physiol. 2017 Jul 26;8:510 - PubMed
  64. J Biol Chem. 1979 Aug 10;254(15):7060-8 - PubMed
  65. Comput Struct Biotechnol J. 2019 May 23;17:661-674 - PubMed
  66. Adv Cancer Res. 2015;126:203-56 - PubMed
  67. FASEB J. 2015 Aug;29(8):3217-27 - PubMed
  68. Oncogenesis. 2017 Jul 10;6(7):e358 - PubMed
  69. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):779-84 - PubMed
  70. Carbohydr Res. 2010 Nov 2;345(16):2334-42 - PubMed
  71. Glycobiology. 2008 Dec;18(12):1105-18 - PubMed
  72. Proteomics. 2008 Aug;8(16):3210-20 - PubMed
  73. Annu Rev Pathol. 2017 Jan 24;12:245-275 - PubMed
  74. Oncol Lett. 2016 Jun;11(6):3889-3895 - PubMed
  75. Mar Drugs. 2013 Jan 09;11(1):81-98 - PubMed
  76. Glycobiology. 1999 Jul;9(7):679-87 - PubMed
  77. J Appl Phycol. 2017;29(2):941-948 - PubMed
  78. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):630-5 - PubMed
  79. Dig Liver Dis. 2013 May;45(5):414-21 - PubMed
  80. J Exp Clin Cancer Res. 2009 Dec 15;28:154 - PubMed
  81. Cell Oncol (Dordr). 2019 Oct;42(5):609-626 - PubMed
  82. EMBO J. 1999 Mar 15;18(6):1516-25 - PubMed
  83. Cell Rep. 2017 Aug 1;20(5):1017-1028 - PubMed
  84. J Cell Biol. 2002 Aug 19;158(4):801-15 - PubMed
  85. Integr Cancer Ther. 2018 Sep;17(3):755-761 - PubMed
  86. Front Oncol. 2018 Dec 07;8:565 - PubMed
  87. Glycobiology. 2016 Feb;26(2):142-54 - PubMed
  88. Oncol Rep. 2017 Dec;38(6):3355-3366 - PubMed
  89. Cancer Res. 1997 Jan 15;57(2):332-6 - PubMed
  90. Natl J Maxillofac Surg. 2015 Jul-Dec;6(2):176-9 - PubMed
  91. Exp Cell Res. 1968 Apr;50(1):127-32 - PubMed
  92. J Proteome Res. 2012 Apr 6;11(4):2508-20 - PubMed
  93. Sci Rep. 2017 Mar 23;7:44990 - PubMed
  94. Oncol Lett. 2018 Jul;16(1):924-930 - PubMed
  95. Cancer Lett. 2003 Oct 28;200(2):167-72 - PubMed
  96. Front Oncol. 2018 Feb 23;8:39 - PubMed
  97. J Clin Diagn Res. 2013 Dec;7(12):2818-20 - PubMed
  98. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7290-5 - PubMed
  99. Onco Targets Ther. 2017 Aug 07;10:3971-3978 - PubMed
  100. Oncotarget. 2017 Apr 25;8(17):28247-28259 - PubMed
  101. J Proteome Res. 2015 Dec 4;14(12):5388-95 - PubMed
  102. Wiley Interdiscip Rev Syst Biol Med. 2016 Nov;8(6):517-535 - PubMed
  103. Biochem Biophys Res Commun. 2016 Apr 29;473(2):503-10 - PubMed
  104. Chem Soc Rev. 2013 May 21;42(10):4459-75 - PubMed
  105. Oncol Rep. 2014 Mar;31(3):1417-22 - PubMed
  106. J Biochem. 2008 Jun;143(6):725-9 - PubMed
  107. Cell Death Dis. 2013 Nov 14;4:e923 - PubMed
  108. Cancer Res. 2000 Mar 1;60(5):1449-56 - PubMed
  109. Biochim Biophys Acta. 2011 Dec;1810(12):1141-9 - PubMed
  110. J Biol Chem. 1994 Jun 17;269(24):16789-94 - PubMed
  111. Glycoconj J. 2017 Apr;34(2):147-156 - PubMed
  112. Sci Rep. 2017 Sep 14;7(1):11563 - PubMed
  113. J Proteomics. 2012 Jul 16;75(13):3963-76 - PubMed
  114. Adv Exp Med Biol. 1995;376:231-8 - PubMed
  115. Biochem J. 2014 May 15;460(1):69-78 - PubMed
  116. Cancer Cell. 2017 Jun 12;31(6):804-819.e7 - PubMed
  117. Afr J Tradit Complement Altern Med. 2017 Jun 05;14(4):149-155 - PubMed
  118. Cell Death Dis. 2016 Aug 25;7(8):e2347 - PubMed
  119. Int J Oncol. 2008 Apr;32(4):797-807 - PubMed
  120. World J Gastroenterol. 2015 Apr 7;21(13):3876-87 - PubMed
  121. Pathol Oncol Res. 2017 Jan;23(1):173-179 - PubMed
  122. Biochimie. 2014 Dec;107 Pt B:286-92 - PubMed
  123. J Cell Biochem. 2018 Jul;119(7):6274-6287 - PubMed
  124. J Cancer Res Clin Oncol. 2007 Sep;133(9):599-611 - PubMed
  125. Hum Mol Genet. 2010 Sep 1;19(17):3468-76 - PubMed
  126. Br J Cancer. 1991 Aug;64(2):386-90 - PubMed
  127. Prostate Cancer Prostatic Dis. 2018 Apr;21(1):137-146 - PubMed
  128. Cancer. 1971 Dec;28(6):1575-9 - PubMed
  129. Int J Mol Sci. 2010 Sep 29;11(10):3748-59 - PubMed
  130. Proteomics. 2014 Mar;14(4-5):525-46 - PubMed
  131. Int J Cancer. 2000 Nov 15;88(4):558-65 - PubMed
  132. Annu Rev Biochem. 2003;72:643-91 - PubMed
  133. Br J Cancer. 2014 Jan 7;110(1):156-63 - PubMed
  134. PLoS One. 2016 Dec 15;11(12):e0168355 - PubMed
  135. Adv Anat Pathol. 2001 Nov;8(6):330-7 - PubMed
  136. Int J Mol Med. 2017 Aug;40(2):293-302 - PubMed
  137. J Biol Chem. 2009 Feb 13;284(7):4723-38 - PubMed
  138. J Biol Chem. 1995 Oct 20;270(42):25047-56 - PubMed
  139. Int J Oncol. 2015 Apr;46(4):1667-76 - PubMed
  140. Nat Commun. 2016 Aug 30;7:12632 - PubMed
  141. Glycoconj J. 2013 Aug;30(6):585-97 - PubMed
  142. Biomolecules. 2012 Jan 30;2(1):34-45 - PubMed
  143. Cancer Immunol Immunother. 2006 Jan;55(1):112-8 - PubMed
  144. Surg Today. 2016 Oct;46(10):1217-23 - PubMed
  145. FEBS Lett. 2015 Aug 19;589(18):2359-66 - PubMed
  146. Cell Death Dis. 2017 Aug 3;8(8):e2968 - PubMed
  147. Glycobiology. 2001 Oct;11(10):119R-128R - PubMed
  148. PLoS One. 2014 Apr 14;9(4):e94536 - PubMed
  149. Biochem Biophys Res Commun. 2012 Jan 6;417(1):311-7 - PubMed
  150. Oncotarget. 2017 Mar 14;8(11):17887-17896 - PubMed
  151. Cancer. 1997 May 1;79(9):1678-85 - PubMed
  152. J Biol Chem. 1994 Sep 9;269(36):22705-11 - PubMed
  153. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6674-8 - PubMed
  154. Glycobiology. 2010 Jan;20(4):452-60 - PubMed
  155. J BUON. 2005 Apr-Jun;10(2):247-50 - PubMed
  156. Glycoconj J. 2008 Dec;25(9):843-50 - PubMed
  157. Arthritis Res Ther. 2014 Jan 28;16(1):R28 - PubMed
  158. Am J Hum Genet. 2018 Dec 6;103(6):1030-1037 - PubMed
  159. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11332-7 - PubMed
  160. Cancer Lett. 1997 Dec 23;121(2):147-53 - PubMed
  161. Cell Res. 2004 Oct;14(5):423-33 - PubMed
  162. PLoS One. 2013 Oct 17;8(10):e77821 - PubMed
  163. Int J Mol Sci. 2018 Feb 15;19(2):null - PubMed
  164. Carbohydr Polym. 2017 Nov 1;175:547-556 - PubMed
  165. Mol Med Rep. 2017 May;15(5):2620-2624 - PubMed
  166. Dev Biol. 2001 May 1;233(1):95-108 - PubMed
  167. Biochimie. 2014 Oct;105:91-8 - PubMed
  168. Oncology. 2015;88(5):298-308 - PubMed
  169. Int J Cancer. 2000 Dec 15;88(6):914-9 - PubMed
  170. Curr Opin Struct Biol. 2019 Jun;56:78-86 - PubMed
  171. Gastroenterology. 1996 Oct;111(4):996-1001 - PubMed
  172. Eur J Biochem. 2001 Jun;268(12):3501-12 - PubMed
  173. Cancer Res. 1988 Jan 15;48(2):475-82 - PubMed
  174. Fen Zi Xi Bao Sheng Wu Xue Bao. 2008 Dec;41(6):435-42 - PubMed
  175. Asian Pac J Cancer Prev. 2015;16(17):7497-500 - PubMed
  176. J Cancer Res Clin Oncol. 2002 Apr;128(4):189-96 - PubMed
  177. Biosci Biotechnol Biochem. 2013;77(2):235-42 - PubMed
  178. Clin Biochem. 2017 Jan;50(1-2):54-61 - PubMed
  179. Glycoconj J. 2007 Jul;24(4-5):207-20 - PubMed
  180. Cancer Lett. 1992 Sep 14;66(1):43-8 - PubMed
  181. Int J Cancer. 1997 Sep 17;72(6):1117-21 - PubMed
  182. Carbohydr Polym. 2018 Mar 15;184:260-268 - PubMed
  183. J Proteome Res. 2009 Jun;8(6):2990-3005 - PubMed
  184. J Biol Chem. 1992 Dec 5;267(34):24575-84 - PubMed
  185. Cancer Res. 1999 May 1;59(9):2237-43 - PubMed
  186. Breast Cancer Res Treat. 2014 Jun;145(2):295-305 - PubMed
  187. Carbohydr Res. 2018 May 23;465:4-9 - PubMed
  188. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19491-6 - PubMed
  189. Oncotarget. 2015 Jan 1;6(1):71-84 - PubMed
  190. Cancer Sci. 2009 May;100(5):888-95 - PubMed
  191. Vox Sang. 1996;70(1):21-5 - PubMed
  192. Oncol Rep. 2017 Nov;38(5):3197-3204 - PubMed
  193. Int J Oncol. 2012 Apr;40(4):1196-202 - PubMed
  194. Sci Signal. 2015 Dec 08;8(406):ra124 - PubMed
  195. Biomed Res Int. 2014;2014:742831 - PubMed
  196. J Natl Cancer Inst. 2016 Apr 13;108(8): - PubMed
  197. J Pathol. 1990 Sep;162(1):23-8 - PubMed
  198. Prog Mol Biol Transl Sci. 2019;162:93-119 - PubMed

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